Somatostatin immunoreactivity in bone and joint tissues
USING immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantif...
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| Veröffentlicht in: | Neuroreport 1998-08, Vol.9 (11), p.2573-2575 |
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| container_title | Neuroreport |
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| creator | Elhassan, Adlan M Adem, Abdu Hultenby, K Lindgren, J U |
| description | USING immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology. |
| doi_str_mv | 10.1097/00001756-199808030-00027 |
| format | Article |
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We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199808030-00027</identifier><identifier>PMID: 9721935</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - metabolism ; Bone and Bones - ultrastructure ; Bone Marrow - metabolism ; Bone Marrow - ultrastructure ; Female ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Joints - metabolism ; Joints - ultrastructure ; Microscopy, Immunoelectron ; Radioimmunoassay ; Rats ; Rats, Inbred Lew ; Skeleton and joints ; Somatostatin - metabolism ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Neuroreport, 1998-08, Vol.9 (11), p.2573-2575</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4537-c44a0e3b3685cedf238c95589524099fa5f01268e00c2aa522ebd3f7dcea16463</citedby><cites>FETCH-LOGICAL-c4537-c44a0e3b3685cedf238c95589524099fa5f01268e00c2aa522ebd3f7dcea16463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1602987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9721935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1955751$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Elhassan, Adlan M</creatorcontrib><creatorcontrib>Adem, Abdu</creatorcontrib><creatorcontrib>Hultenby, K</creatorcontrib><creatorcontrib>Lindgren, J U</creatorcontrib><title>Somatostatin immunoreactivity in bone and joint tissues</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>USING immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - ultrastructure</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow - ultrastructure</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Joints - metabolism</subject><subject>Joints - ultrastructure</subject><subject>Microscopy, Immunoelectron</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Skeleton and joints</subject><subject>Somatostatin - metabolism</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi1UVJaFn4CUQ9VbwB9x7DlWVQtIlTgAEjfLcSaq2yRebKer_ntcNmxPFT7Yo5lnxuN5TUjF6EdGQX2iZTEl25oBaKqpoHXxcPWKbFijRC2l_nVCNhQk1A208g15m9JdQYAyfUpOQXEGQm6I-h4mm0PKNvu58tO0zCGiddk_-PxYFV8XZqzs3Fd3wc-5yj6lBdM78nqwY8L367klP6-vflx-qW--ff56eXFTu0YKVfbGUhSdaLV02A9caAelOZC8oQCDlQNlvNVIqePWSs6x68WgeoeWtU0rtqQ-1E173C2d2UU_2fhogvVmdd0XC00jhG5V4c8P_C6G36XPbCafHI6jnTEsyahCAVD4L8gUK1Mtj9gSfQBdDClFHI49MGqexDD_xDBHMcxfMUrqh_WOpZuwPyau0y_xszVuk7PjEO3sfHqu31IO-qlMc8D2YcwY0_247DGaW7RjvjUvfQXxBwByoRc</recordid><startdate>19980803</startdate><enddate>19980803</enddate><creator>Elhassan, Adlan M</creator><creator>Adem, Abdu</creator><creator>Hultenby, K</creator><creator>Lindgren, J U</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19980803</creationdate><title>Somatostatin immunoreactivity in bone and joint tissues</title><author>Elhassan, Adlan M ; Adem, Abdu ; Hultenby, K ; Lindgren, J U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4537-c44a0e3b3685cedf238c95589524099fa5f01268e00c2aa522ebd3f7dcea16463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - ultrastructure</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Marrow - ultrastructure</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Joints - metabolism</topic><topic>Joints - ultrastructure</topic><topic>Microscopy, Immunoelectron</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Skeleton and joints</topic><topic>Somatostatin - metabolism</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elhassan, Adlan M</creatorcontrib><creatorcontrib>Adem, Abdu</creatorcontrib><creatorcontrib>Hultenby, K</creatorcontrib><creatorcontrib>Lindgren, J U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elhassan, Adlan M</au><au>Adem, Abdu</au><au>Hultenby, K</au><au>Lindgren, J U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin immunoreactivity in bone and joint tissues</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1998-08-03</date><risdate>1998</risdate><volume>9</volume><issue>11</issue><spage>2573</spage><epage>2575</epage><pages>2573-2575</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>USING immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9721935</pmid><doi>10.1097/00001756-199808030-00027</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Biological and medical sciences Bone and Bones - metabolism Bone and Bones - ultrastructure Bone Marrow - metabolism Bone Marrow - ultrastructure Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Joints - metabolism Joints - ultrastructure Microscopy, Immunoelectron Radioimmunoassay Rats Rats, Inbred Lew Skeleton and joints Somatostatin - metabolism Vertebrates: osteoarticular system, musculoskeletal system |
| title | Somatostatin immunoreactivity in bone and joint tissues |
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