The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses

C Hultgren, DR Milich, O Weiland and M Sallberg Division of Clinical Virology, Huddinge University Hospital, Sweden. Ribavirin is effective in combination therapies against chronic hepatitis C virus (HCV) infection, although its direct antiviral properties are unclear. We therefore studied the immun...

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Veröffentlicht in:	Journal of general virology 1998-10, Vol.79 (10), p.2381-2391
Hauptverfasser:	Hultgren, C, Milich, DR, Weiland, O, Sallberg, M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antiviral Agents - pharmacology Cytokines - biosynthesis Hepacivirus - immunology Hepatitis B Antibodies - blood Hepatitis B e Antigens - immunology Hepatitis B virus Hepatitis B virus - immunology Hepatitis C Antibodies - blood Hepatitis C virus Humans Lymphocyte Activation - drug effects Mice Mice, Inbred BALB C Ribavirin - pharmacology RNA, Viral - analysis Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology
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