Periodontal Conditions and Salivary Immunoglobulins in Individuals With Down Syndrome
Periodontal conditions and salivary levels of Immunoglobulins slgA, IgM, and IgG subclass distribution and albumin, quantified by enzyme‐linked immunosorbent assay, were determined in 20 patients with Down syndrome and 19 healthy controls. Gingival inflammation was more extensive (P < 0.05) among...
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| Veröffentlicht in: | Journal of periodontology (1970) 1998-10, Vol.69 (10), p.1119-1123 |
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| container_title | Journal of periodontology (1970) |
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| creator | Barr‐Agholme, Monica Dahllöf, Göran Modéer, Thomas Engström, Per‐Erik Engström, Gunilla Norhagen |
| description | Periodontal conditions and salivary levels of Immunoglobulins slgA, IgM, and IgG subclass distribution and albumin, quantified by enzyme‐linked immunosorbent assay, were determined in 20 patients with Down syndrome and 19 healthy controls. Gingival inflammation was more extensive (P < 0.05) among Down syndrome subjects compared to controls as well as the occurrence of periodontal pockets (< 4 mm) (P < 0.05). The immunoglobuhn levels of slgA, IgM, the sum of IgG subclasses, and the concentration of albumin did not differ significantly between the 2 groups. However, the proportion of IgGl expressed as percentage of the sum of total IgG was significantly higher (P < 0.01) in the Down syndrome group compared to controls. On the contrary, the proportion of IgG2, IgG3, and IgG4 subclasses in saliva did not differ between the 2 groups. The results indicate an altered distribution of IgG subclasses in saliva, with a higher proportion of IgGl in Down syndrome individuals compared to controls. J Periodontol 1998;69:1119–1123. |
| doi_str_mv | 10.1902/jop.1998.69.10.1119 |
| format | Article |
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Gingival inflammation was more extensive (P < 0.05) among Down syndrome subjects compared to controls as well as the occurrence of periodontal pockets (< 4 mm) (P < 0.05). The immunoglobuhn levels of slgA, IgM, the sum of IgG subclasses, and the concentration of albumin did not differ significantly between the 2 groups. However, the proportion of IgGl expressed as percentage of the sum of total IgG was significantly higher (P < 0.01) in the Down syndrome group compared to controls. On the contrary, the proportion of IgG2, IgG3, and IgG4 subclasses in saliva did not differ between the 2 groups. The results indicate an altered distribution of IgG subclasses in saliva, with a higher proportion of IgGl in Down syndrome individuals compared to controls. 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Gingival inflammation was more extensive (P < 0.05) among Down syndrome subjects compared to controls as well as the occurrence of periodontal pockets (< 4 mm) (P < 0.05). The immunoglobuhn levels of slgA, IgM, the sum of IgG subclasses, and the concentration of albumin did not differ significantly between the 2 groups. However, the proportion of IgGl expressed as percentage of the sum of total IgG was significantly higher (P < 0.01) in the Down syndrome group compared to controls. On the contrary, the proportion of IgG2, IgG3, and IgG4 subclasses in saliva did not differ between the 2 groups. The results indicate an altered distribution of IgG subclasses in saliva, with a higher proportion of IgGl in Down syndrome individuals compared to controls. J Periodontol 1998;69:1119–1123.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Albumins - analysis</subject><subject>Alveolar Bone Loss - etiology</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Dental Calculus - etiology</subject><subject>Dentistry</subject><subject>Down syndrome</subject><subject>Down Syndrome - complications</subject><subject>Down Syndrome - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gingival Hemorrhage - etiology</subject><subject>Gingivitis - etiology</subject><subject>Humans</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulins</subject><subject>Male</subject><subject>Periodontal Diseases - etiology</subject><subject>periodontal index</subject><subject>Periodontal Pocket - etiology</subject><subject>Saliva - immunology</subject><subject>Salivary Proteins and Peptides - analysis</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OwzAQhC0EKqXwBAgpJ24pdjaJ4yMqBYoqUVEqjpYTO-CS2CVOWvXtcX_EmZPXM7Oj1YfQNcFDwnB0t7QrP7BsmLLhTiOEnaA-YTGEkFJ8ivoYR1EIMYvO0YVzS_8lMeAe6rEMR5TgPlrMVKOttKYVVTCyRupWW-MCYWQwF5Vei2YbTOq6M_azsnlXaW9qE0x8cq1lJyoXfOj2K3iwGxPMt0Y2tlaX6Kz0jro6vgO0eBy_j57D6evTZHQ_DQvIMhaWsshZBpAoliQYciUJQIpVnADNMBUFpkoRIlkWg6RRUZJSpDlQnNAkxwWDAQoPvW6jVl3OV42u_cHcCs2P0refFI8BohR8_vaQXzX2p1Ou5bV2haoqYZTtHKeeUJySxAfhECwa61yjyr9qgvkOPvfw-Q4-T9le8_D91s2xvstrJf92jrS9zw7-Rldq-59K_jIbv-27fwHK15MN</recordid><startdate>199810</startdate><enddate>199810</enddate><creator>Barr‐Agholme, Monica</creator><creator>Dahllöf, Göran</creator><creator>Modéer, Thomas</creator><creator>Engström, Per‐Erik</creator><creator>Engström, Gunilla Norhagen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>199810</creationdate><title>Periodontal Conditions and Salivary Immunoglobulins in Individuals With Down Syndrome</title><author>Barr‐Agholme, Monica ; Dahllöf, Göran ; Modéer, Thomas ; Engström, Per‐Erik ; Engström, Gunilla Norhagen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-fdcb98335e95503bed13360e4537807ac07ee11d9843d72cf1fa6b370575b0c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Albumins - analysis</topic><topic>Alveolar Bone Loss - etiology</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Dental Calculus - etiology</topic><topic>Dentistry</topic><topic>Down syndrome</topic><topic>Down Syndrome - complications</topic><topic>Down Syndrome - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gingival Hemorrhage - etiology</topic><topic>Gingivitis - etiology</topic><topic>Humans</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulins</topic><topic>Male</topic><topic>Periodontal Diseases - etiology</topic><topic>periodontal index</topic><topic>Periodontal Pocket - etiology</topic><topic>Saliva - immunology</topic><topic>Salivary Proteins and Peptides - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barr‐Agholme, Monica</creatorcontrib><creatorcontrib>Dahllöf, Göran</creatorcontrib><creatorcontrib>Modéer, Thomas</creatorcontrib><creatorcontrib>Engström, Per‐Erik</creatorcontrib><creatorcontrib>Engström, Gunilla Norhagen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barr‐Agholme, Monica</au><au>Dahllöf, Göran</au><au>Modéer, Thomas</au><au>Engström, Per‐Erik</au><au>Engström, Gunilla Norhagen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Periodontal Conditions and Salivary Immunoglobulins in Individuals With Down Syndrome</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>1998-10</date><risdate>1998</risdate><volume>69</volume><issue>10</issue><spage>1119</spage><epage>1123</epage><pages>1119-1123</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Periodontal conditions and salivary levels of Immunoglobulins slgA, IgM, and IgG subclass distribution and albumin, quantified by enzyme‐linked immunosorbent assay, were determined in 20 patients with Down syndrome and 19 healthy controls. Gingival inflammation was more extensive (P < 0.05) among Down syndrome subjects compared to controls as well as the occurrence of periodontal pockets (< 4 mm) (P < 0.05). The immunoglobuhn levels of slgA, IgM, the sum of IgG subclasses, and the concentration of albumin did not differ significantly between the 2 groups. However, the proportion of IgGl expressed as percentage of the sum of total IgG was significantly higher (P < 0.01) in the Down syndrome group compared to controls. On the contrary, the proportion of IgG2, IgG3, and IgG4 subclasses in saliva did not differ between the 2 groups. The results indicate an altered distribution of IgG subclasses in saliva, with a higher proportion of IgGl in Down syndrome individuals compared to controls. J Periodontol 1998;69:1119–1123.</abstract><cop>United States</cop><pmid>9802710</pmid><doi>10.1902/jop.1998.69.10.1119</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Albumins - analysis Alveolar Bone Loss - etiology Case-Control Studies Child Dental Calculus - etiology Dentistry Down syndrome Down Syndrome - complications Down Syndrome - immunology Enzyme-Linked Immunosorbent Assay Female Gingival Hemorrhage - etiology Gingivitis - etiology Humans Immunoglobulin A, Secretory - analysis Immunoglobulin G - analysis Immunoglobulin G - classification Immunoglobulin M - analysis Immunoglobulins Male Periodontal Diseases - etiology periodontal index Periodontal Pocket - etiology Saliva - immunology Salivary Proteins and Peptides - analysis |
| title | Periodontal Conditions and Salivary Immunoglobulins in Individuals With Down Syndrome |
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