Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G

Human mast cell chymase (HC) and human neutrophil cathepsin G (hCG) show relatively similar cleavage specificities: they both have chymotryptic activity but can also cleave efficiently after leucine. Their relatively broad specificity suggests that they may cleave almost any substrate if present in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2017-02, Vol.198 (4), p.1474-1483
Hauptverfasser:	Fu, Zhirong, Thorpe, Michael, Alemayehu, Rahel, Roy, Ananya, Kervinen, Jukka, de Garavilla, Lawrence, Åbrink, Magnus, Hellman, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Alarmins - metabolism Biochemistry and Molecular Biology Biokemi och molekylärbiologi Cathepsin G Cathepsin G - metabolism Chemokines Chemokines - genetics Chemokines - metabolism Chymase Chymases - metabolism Cleavage Cytokines Cytokines - genetics Cytokines - metabolism Enzymes Homeostasis Homeostasis - immunology Humans Immunologi Immunology Inflammation Interleukin 1 Interleukin 15 Interleukin 18 Interleukin-1 - metabolism Interleukin-15 - metabolism Interleukin-18 - metabolism Interleukin-33 - metabolism Killer Cells, Natural - physiology Leucine Lymphocytes T Mast Cells - enzymology Mast Cells - immunology Mast Cells - physiology Natural killer cells Neutrophils Neutrophils - immunology Neutrophils - metabolism Peptides Proteins Selectivity Substrate Specificity Substrates T-Lymphocytes - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!