Hyperactivity of the Arabidopsis cryptochrome (cry1) L407F mutant is caused by a structural alteration close to the cry1 ATP-binding site

Plant cryptochromes (cry) act as UV-A/blue light receptors. The prototype, Arabidopsis thaliana cry1, regulates several light responses during the life cycle, including de-etiolation, and is also involved in regulating flowering time. The cry1 photocycle is initiated by light absorption by its FAD c...

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Veröffentlicht in:	The Journal of biological chemistry 2017-08, Vol.292 (31), p.12906-12920
Hauptverfasser:	Orth, Christian, Niemann, Nils, Hennig, Lars, Essen, Lars-Oliver, Batschauer, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Amino Acid Substitution Arabidopsis - metabolism Arabidopsis Proteins - antagonists & inhibitors Arabidopsis Proteins - chemistry Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism ATP Binding Sites Binding, Competitive Biocatalysis Botanik Botany cryptochrome Cryptochromes - antagonists & inhibitors Cryptochromes - chemistry Cryptochromes - genetics Cryptochromes - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Hot Temperature - adverse effects Indazoles - chemistry Indazoles - metabolism Indazoles - pharmacology Ligands Models, Molecular Molecular Docking Simulation Mutagenesis, Site-Directed Mutation nucleotide nucleotide binding Peptide Fragments - antagonists & inhibitors Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism photobiology plant biochemistry Plant Biology Protein Conformation Protein Denaturation Protein Interaction Domains and Motifs Protein Stability Recombinant Proteins - chemistry Recombinant Proteins - metabolism Structural Homology, Protein
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