Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors

Regulatory T (T reg) cell deficiency causes lethal, CD4 T cell-driven autoimmune diseases. Stem cell transplantation is used to treat these diseases, but this procedure is limited by the availability of a suitable donor. The intestinal microbiota drives host immune homeostasis by regulating the diff...

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Veröffentlicht in:	The Journal of experimental medicine 2017-01, Vol.214 (1), p.107-123
Hauptverfasser:	He, Baokun, Hoang, Thomas K, Wang, Ting, Ferris, Michael, Taylor, Christopher M, Tian, Xiangjun, Luo, Meng, Tran, Dat Q, Zhou, Jain, Tatevian, Nina, Luo, Fayong, Molina, Jose G, Blackburn, Michael R, Gomez, Thomas H, Roos, Stefan, Rhoads, J Marc, Liu, Yuying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine A2A receptors Animals Autoimmune diseases Autoimmunity CD4 antigen Cell Differentiation Cytokines Differentiation Digestive system Dysbacteriosis Female Foxp3 protein Gastrointestinal Microbiome Gastrointestinal tract Helper cells Homeostasis Immunologi Immunology Inosine - pharmacology Intestinal microflora Intestine Lactobacillus reuteri Life span Lymphocytes T Male Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) Metabolomics Mice Mice, Inbred C57BL Microbiology Microbiota Microorganisms Mikrobiologi Receptor, Adenosine A2A - physiology Receptors T-Lymphocytes, Regulatory - immunology Th1 Cells - cytology Th2 Cells - cytology Transplantation
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