Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

During infection and tissue damage, virulence factors and alarmins are pro-inflammatory and induce activation of various immune cells including macrophages and mast cells (MCs). Activated MCs instantly release preformed inflammatory mediators, including several proteases. The chymase mouse mast cell...

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Veröffentlicht in:	The Journal of biological chemistry 2014-01, Vol.289 (1), p.237-250
Hauptverfasser:	Roy, Ananya, Ganesh, Goutham, Sippola, Helena, Bolin, Sara, Sawesi, Osama, Dagälv, Anders, Schlenner, Susan M., Feyerabend, Thorsten, Rodewald, Hans-Reimer, Kjellén, Lena, Hellman, Lars, Åbrink, Magnus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biglycan Biglycan - genetics Biglycan - metabolism Chymases - genetics Chymases - metabolism Helminth Proteins - genetics Helminth Proteins - metabolism High Mobility Group Box Protein 1 HMGB1 Protein - genetics HMGB1 Protein - metabolism Hsp70 HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans IL-33 Immunology Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Innate Immunity Interleukin-33 Interleukins - genetics Interleukins - metabolism Mast Cell Mast Cells - metabolism Mast Cells - pathology Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) Mice Mice, Knockout Proteolysis Serine Protease Trichinella spiralis - genetics Trichinella spiralis - metabolism Tumor Necrosis Factor (TNF) Virulence Factors Virulence Factors - genetics Virulence Factors - metabolism
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