Detection and correction of interference in SRM analysis

Selected Reaction Monitoring (SRM) is a method of choice for accurate quantitation of low-abundance proteins in complex backgrounds. This strategy is, however, sensitive to interference from other components in the sample that have the same precursor and fragment masses as the monitored transitions....

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Veröffentlicht in:	Methods (San Diego, Calif.) Calif.), 2013-06, Vol.61 (3), p.299-303
Hauptverfasser:	Bao, Y., Waldemarson, S., Zhang, G., Wahlander, A., Ueberheide, B., Myung, S., Reed, B., Molloy, K., Padovan, J.C., Eriksson, J., Neubert, T.A., Chait, B.T., Fenyö, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analytical Chemistry Analytisk kemi Bioinformatics and Systems Biology Bioinformatik och systembiologi Calibration Humans Interference correction Interference detection Linear range detection Mass spectrometry Peptide Fragments - analysis Proteins - analysis Proteomics - methods Proteomics - statistics & numerical data Selected reaction monitoring Signal-To-Noise Ratio Tandem Mass Spectrometry - standards Validation Studies as Topic
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