The Expression of the Insulin-like Growth Factor II, JIP-1 and WT1 Genes in Porcine Nephroblastoma
c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP-1) is an important scaffolding protein in the JNK signalling pathway. It is also believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Previous studies have suggested that the JIP gene is...
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| description | c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP-1) is an important scaffolding protein in the JNK signalling pathway.
It is also believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Previous
studies have suggested that the JIP gene is co-regulated with the insulin-like growth factor II (IGF-II) gene, thereby contributing
to the growth stimulatory effects of this potent growth factor. The striking co-expression of these two genes has been found
in murine foetuses as well as in primary human embryonic tumours. When six primary Wilms tumours (nephroblastomas) from pig
were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high
or low expression of JIP-1 ocurred together. By contrast the expression of a third Wilms tumour-related gene, WT1, was completely
uncorrelated to the expression of IGF-II and JIP. In this respect, porcine nephroblastomas resemble human Wilms tumours. This
further suggests that JIP-1 may play a role in the regulation of IGF-II-driven tumour cell proliferation. |
| format | Article |
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It is also believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Previous
studies have suggested that the JIP gene is co-regulated with the insulin-like growth factor II (IGF-II) gene, thereby contributing
to the growth stimulatory effects of this potent growth factor. The striking co-expression of these two genes has been found
in murine foetuses as well as in primary human embryonic tumours. When six primary Wilms tumours (nephroblastomas) from pig
were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high
or low expression of JIP-1 ocurred together. By contrast the expression of a third Wilms tumour-related gene, WT1, was completely
uncorrelated to the expression of IGF-II and JIP. In this respect, porcine nephroblastomas resemble human Wilms tumours. This
further suggests that JIP-1 may play a role in the regulation of IGF-II-driven tumour cell proliferation.</description><identifier>ISSN: 0250-7005</identifier><identifier>ISSN: 1791-7530</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 20044608</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Animal and Dairy Science ; Animals ; Animals, Newborn ; Blotting, Northern ; Cell Proliferation ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Neoplastic ; Humans ; Husdjursvetenskap ; Insulin-Like Growth Factor II - genetics ; Insulin-Like Growth Factor II - metabolism ; Kidney - metabolism ; Kidney - pathology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - metabolism ; Mice ; Signal Transduction ; Swine ; Veterinary Science ; Veterinärmedicin ; Wilms Tumor - genetics ; Wilms Tumor - metabolism ; WT1 Proteins - genetics ; WT1 Proteins - metabolism</subject><ispartof>Anticancer research, 2009-12, Vol.29 (12), p.4999-5003</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20044608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://res.slu.se/id/publ/48849$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Engstroem, W</creatorcontrib><creatorcontrib>Granerus, M</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><title>The Expression of the Insulin-like Growth Factor II, JIP-1 and WT1 Genes in Porcine Nephroblastoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP-1) is an important scaffolding protein in the JNK signalling pathway.
It is also believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Previous
studies have suggested that the JIP gene is co-regulated with the insulin-like growth factor II (IGF-II) gene, thereby contributing
to the growth stimulatory effects of this potent growth factor. The striking co-expression of these two genes has been found
in murine foetuses as well as in primary human embryonic tumours. When six primary Wilms tumours (nephroblastomas) from pig
were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high
or low expression of JIP-1 ocurred together. By contrast the expression of a third Wilms tumour-related gene, WT1, was completely
uncorrelated to the expression of IGF-II and JIP. In this respect, porcine nephroblastomas resemble human Wilms tumours. This
further suggests that JIP-1 may play a role in the regulation of IGF-II-driven tumour cell proliferation.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Animal and Dairy Science</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Blotting, Northern</subject><subject>Cell Proliferation</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Husdjursvetenskap</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Mice</subject><subject>Signal Transduction</subject><subject>Swine</subject><subject>Veterinary Science</subject><subject>Veterinärmedicin</subject><subject>Wilms Tumor - genetics</subject><subject>Wilms Tumor - metabolism</subject><subject>WT1 Proteins - genetics</subject><subject>WT1 Proteins - metabolism</subject><issn>0250-7005</issn><issn>1791-7530</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EFP3DAQBeCoKioL7V-ofKKXRrJjO7aPCME2FQIOizha42S2MThxaida-PddtNArpyc9fRqN3qdixZRhpZKcfi5WtJK0VJTK4-Ik50dK69po_qU4rigVoqZ6VbhNj-TyeUqYs48jiVsy75tmzEvwYxn8E5J1iru5J1fQzjGRpvlJfjd3JSMwduRhw8gaR8zEj-QuptaPSG5w6lN0AfIcB_haHG0hZPz2lqfF_dXl5uJXeX27bi7Or8ueMzaXstMVtMwAVVxKp7RR0gBqrnQHyLVG1dWuVlI4rZSsELasA1cbt2WKth0_LcrD3bzDaXF2Sn6A9GIjeJvD4iC9hs1ohdbC7P2Pg59S_Ltgnu3gc4shwIhxyVYJaSjVgn4suaiYlvWr_P4mFzdg9_-H98H34OwAev-n3_mENg8Qwp5zC6kyllVWGGP4P8v7iQM</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Engstroem, W</creator><creator>Granerus, M</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20091201</creationdate><title>The Expression of the Insulin-like Growth Factor II, JIP-1 and WT1 Genes in Porcine Nephroblastoma</title><author>Engstroem, W ; Granerus, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h311t-5d82ac19a07355b789759ae8378dae388e7d6b6754b87752eaf1dab69bf170cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Animal and Dairy Science</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Blotting, Northern</topic><topic>Cell Proliferation</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Husdjursvetenskap</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Mice</topic><topic>Signal Transduction</topic><topic>Swine</topic><topic>Veterinary Science</topic><topic>Veterinärmedicin</topic><topic>Wilms Tumor - genetics</topic><topic>Wilms Tumor - metabolism</topic><topic>WT1 Proteins - genetics</topic><topic>WT1 Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engstroem, W</creatorcontrib><creatorcontrib>Granerus, M</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engstroem, W</au><au>Granerus, M</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Expression of the Insulin-like Growth Factor II, JIP-1 and WT1 Genes in Porcine Nephroblastoma</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>29</volume><issue>12</issue><spage>4999</spage><epage>5003</epage><pages>4999-5003</pages><issn>0250-7005</issn><issn>1791-7530</issn><eissn>1791-7530</eissn><abstract>c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP-1) is an important scaffolding protein in the JNK signalling pathway.
It is also believed to play a role in the mediation of mitogenic messages from the plasma membrane to the cell interior. Previous
studies have suggested that the JIP gene is co-regulated with the insulin-like growth factor II (IGF-II) gene, thereby contributing
to the growth stimulatory effects of this potent growth factor. The striking co-expression of these two genes has been found
in murine foetuses as well as in primary human embryonic tumours. When six primary Wilms tumours (nephroblastomas) from pig
were examined, the two genes showed a high degree of co-variation in the sense that high or low expression of IGF-II and high
or low expression of JIP-1 ocurred together. By contrast the expression of a third Wilms tumour-related gene, WT1, was completely
uncorrelated to the expression of IGF-II and JIP. In this respect, porcine nephroblastomas resemble human Wilms tumours. This
further suggests that JIP-1 may play a role in the regulation of IGF-II-driven tumour cell proliferation.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>20044608</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animal and Dairy Science Animals Animals, Newborn Blotting, Northern Cell Proliferation Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Humans Husdjursvetenskap Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Kidney - metabolism Kidney - pathology Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Mice Signal Transduction Swine Veterinary Science Veterinärmedicin Wilms Tumor - genetics Wilms Tumor - metabolism WT1 Proteins - genetics WT1 Proteins - metabolism |
| title | The Expression of the Insulin-like Growth Factor II, JIP-1 and WT1 Genes in Porcine Nephroblastoma |
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