In vivo effect of dried chicory root ( Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver

Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2, 2A and 2E1 are important for the metabolism of skatole. Feeding chicory roots to pigs is known to decrease the skatole concentration in plasma and fat. In...

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Veröffentlicht in:	Toxicology letters 2011-01, Vol.200 (1), p.88-91
Hauptverfasser:	Rasmussen, Martin Krøyer, Zamaratskaia, Galia, Ekstrand, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal and Dairy Science Animals Aryl Hydrocarbon Hydroxylases - drug effects Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Blotting, Western Chicory Cichorium intybus Cytochrome P-450 CYP1A2 - drug effects Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP2E1 - drug effects Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 Enzyme System - drug effects Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Enzyme Activation - drug effects Husdjursvetenskap Inactivation, Metabolic Male Medical sciences Microsomes Microsomes, Liver - drug effects Microsomes, Liver - enzymology Plant Preparations - pharmacology Plant Roots Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RT-PCR Steroid Hydroxylases - drug effects Steroid Hydroxylases - metabolism Swine Toxicology Veterinary Science Veterinärmedicin Western blotting
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