Structural and functional studies of mycobacterial IspD enzymes

A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans. As part of a structure‐based drug‐discovery program against tu...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2011-05, Vol.67 (5), p.403-414
Hauptverfasser:	Björkelid, Christofer, Bergfors, Terese, Henriksson, Lena M., Stern, Ana Laura, Unge, Torsten, Mowbray, Sherry L., Jones, T. Alwyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antitubercular Agents - pharmacology Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biochemistry and Molecular Biology Biokemi och molekylärbiologi Biologi Biology Construction Crystal structure Crystallography Drug Design Enzyme Inhibitors - pharmacology Enzymes Erythritol - analogs & derivatives Erythritol - metabolism Flexibility Hemiterpenes - metabolism Humans Inhibitors IspD MEP pathway Molecular Sequence Data Mycobacterium smegmatis Mycobacterium smegmatis - chemistry Mycobacterium smegmatis - enzymology Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - enzymology NATURAL SCIENCES NATURVETENSKAP Organophosphorus Compounds - metabolism Pathways Sequence Alignment Sugar Phosphates - metabolism Tuberculosis Tuberculosis - drug therapy Tuberculosis - enzymology
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