Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

The mechanisms that govern whether a cell dies by apoptosis or necrosis are not fully understood. Here we show that serglycin, a secretory granule proteoglycan of hematopoietic cells, can have a major impact on this decision. Wild type and serglycin−/− mast cells were equally sensitive to a range of...

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