Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis

Mast cell (MC) granules contain large amounts of proteases of the chymase, tryptase and carboxypeptidase A (MC-CPA) type that are stored in complex with serglycin, a proteoglycan with heparin side chains. Hence, serglycin-protease complexes are released upon MC degranulation and may influence local...

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Veröffentlicht in:	Biological chemistry 2012-12, Vol.393 (12), p.1555-1567
Hauptverfasser:	Waern, Ida, Karlsson, Iulia, Thorpe, Michael, Schlenner, Susan M., Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Åbrink, Magnus, Hellman, Lars, Pejler, Gunnar, Wernersson, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	allergy Animals Carboxypeptidases A - genetics Carboxypeptidases A - immunology Carboxypeptidases A - metabolism Cell and Molecular Biology Cell Degranulation Cell- och molekylärbiologi Cells, Cultured cytokine Gene Deletion Heparin - immunology Heparin - metabolism Heparin Antagonists - pharmacology Hypersensitivity - immunology Hypersensitivity - metabolism Interleukin-13 - immunology Interleukin-13 - metabolism mast cell Mast Cells - physiology Medical Bioscience Medicinsk biovetenskap Mice Peritoneum - cytology proteoglycan Proteoglycans - genetics Proteoglycans - immunology Proteoglycans - metabolism Proteolysis serine protease Serine Proteases - immunology Serine Proteases - metabolism Serine Proteinase Inhibitors - pharmacology Vesicular Transport Proteins - genetics Vesicular Transport Proteins - immunology Vesicular Transport Proteins - metabolism
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