Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge
Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-da...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2022, Vol.84(12), pp.1595-1604 |
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| creator | CUEVAS-ROMERO, Julieta Sandra CERRITEÑO-SÁNCHEZ, José Luis LARA-ROMERO, Rocío VEGA-LÓPEZ, Marco Antonio RAMÍREZ-ESTUDILLO, Carmen RAMÍREZ-MENDOZA, Humberto BERG, Mikael LÖVGREN-BENGTSSON, Karin |
| description | Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day-old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN-PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n=8), survived, respectively, showing milder PRV clinical signs. Our data indicate that rHN-PorPV candidate vaccine produced in Escherichia coli induces efficient humoral response in pregnant sows and that the maternally derived immunity provides high protection to suckling piglets against PRV lethal challenge. |
| doi_str_mv | 10.1292/jvms.22-0207 |
| format | Article |
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This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day-old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN-PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n=8), survived, respectively, showing milder PRV clinical signs. Our data indicate that rHN-PorPV candidate vaccine produced in Escherichia coli induces efficient humoral response in pregnant sows and that the maternally derived immunity provides high protection to suckling piglets against PRV lethal challenge.</description><identifier>ISSN: 0916-7250</identifier><identifier>ISSN: 1347-7439</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.22-0207</identifier><identifier>PMID: 36273875</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animal and Dairy Science ; Animals ; Antibodies, Viral ; Clinical Science ; Colostrum ; E coli ; Enzyme-linked immunosorbent assay ; Escherichia coli ; Escherichia coli - genetics ; Escherichia coli Infections - veterinary ; Exo-a-sialidase ; Female ; hemagglutinin-neuraminidase ; Hemagglutinins ; Hogs ; Husdjursvetenskap ; Immune response (humoral) ; immune-stimulating complex ; Immunogenicity ; Immunoglobulin G ; ISCOMS ; Klinisk vetenskap ; Neuraminidase - genetics ; Porcine rubulavirus ; Pregnancy ; recombinant vaccine ; Suckling behavior ; Swine ; Swine Diseases ; Vaccines ; Viral Proteins ; Virology</subject><ispartof>Journal of Veterinary Medical Science, 2022, Vol.84(12), pp.1595-1604</ispartof><rights>2022 by the Japanese Society of Veterinary Science</rights><rights>2022. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 The Japanese Society of Veterinary Science 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-6dbfb2a70778bfcccd2a6526c03b513fd47603e64e78563da3021586cdf5613a3</citedby><cites>FETCH-LOGICAL-c588t-6dbfb2a70778bfcccd2a6526c03b513fd47603e64e78563da3021586cdf5613a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791230/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791230/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,1877,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36273875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://res.slu.se/id/publ/122096$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>CUEVAS-ROMERO, Julieta Sandra</creatorcontrib><creatorcontrib>CERRITEÑO-SÁNCHEZ, José Luis</creatorcontrib><creatorcontrib>LARA-ROMERO, Rocío</creatorcontrib><creatorcontrib>VEGA-LÓPEZ, Marco Antonio</creatorcontrib><creatorcontrib>RAMÍREZ-ESTUDILLO, Carmen</creatorcontrib><creatorcontrib>RAMÍREZ-MENDOZA, Humberto</creatorcontrib><creatorcontrib>BERG, Mikael</creatorcontrib><creatorcontrib>LÖVGREN-BENGTSSON, Karin</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><title>Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day-old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN-PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n=8), survived, respectively, showing milder PRV clinical signs. 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CERRITEÑO-SÁNCHEZ, José Luis ; LARA-ROMERO, Rocío ; VEGA-LÓPEZ, Marco Antonio ; RAMÍREZ-ESTUDILLO, Carmen ; RAMÍREZ-MENDOZA, Humberto ; BERG, Mikael ; LÖVGREN-BENGTSSON, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-6dbfb2a70778bfcccd2a6526c03b513fd47603e64e78563da3021586cdf5613a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animal and Dairy Science</topic><topic>Animals</topic><topic>Antibodies, Viral</topic><topic>Clinical Science</topic><topic>Colostrum</topic><topic>E coli</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Escherichia coli</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli Infections - veterinary</topic><topic>Exo-a-sialidase</topic><topic>Female</topic><topic>hemagglutinin-neuraminidase</topic><topic>Hemagglutinins</topic><topic>Hogs</topic><topic>Husdjursvetenskap</topic><topic>Immune response (humoral)</topic><topic>immune-stimulating complex</topic><topic>Immunogenicity</topic><topic>Immunoglobulin G</topic><topic>ISCOMS</topic><topic>Klinisk vetenskap</topic><topic>Neuraminidase - genetics</topic><topic>Porcine rubulavirus</topic><topic>Pregnancy</topic><topic>recombinant vaccine</topic><topic>Suckling behavior</topic><topic>Swine</topic><topic>Swine Diseases</topic><topic>Vaccines</topic><topic>Viral Proteins</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUEVAS-ROMERO, Julieta Sandra</creatorcontrib><creatorcontrib>CERRITEÑO-SÁNCHEZ, José Luis</creatorcontrib><creatorcontrib>LARA-ROMERO, Rocío</creatorcontrib><creatorcontrib>VEGA-LÓPEZ, Marco Antonio</creatorcontrib><creatorcontrib>RAMÍREZ-ESTUDILLO, Carmen</creatorcontrib><creatorcontrib>RAMÍREZ-MENDOZA, Humberto</creatorcontrib><creatorcontrib>BERG, Mikael</creatorcontrib><creatorcontrib>LÖVGREN-BENGTSSON, Karin</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUEVAS-ROMERO, Julieta Sandra</au><au>CERRITEÑO-SÁNCHEZ, José Luis</au><au>LARA-ROMERO, Rocío</au><au>VEGA-LÓPEZ, Marco Antonio</au><au>RAMÍREZ-ESTUDILLO, Carmen</au><au>RAMÍREZ-MENDOZA, Humberto</au><au>BERG, Mikael</au><au>LÖVGREN-BENGTSSON, Karin</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2022</date><risdate>2022</risdate><volume>84</volume><issue>12</issue><spage>1595</spage><epage>1604</epage><pages>1595-1604</pages><artnum>22-0207</artnum><issn>0916-7250</issn><issn>1347-7439</issn><eissn>1347-7439</eissn><abstract>Porcine rubulavirus (PRV) is a contagious virus that affects the Mexican swine industry. This work aimed to evaluate the immunogenicity of an recombinant hemagglutinin neuraminidase-Porcine rubulavirus (rHN-PorPV) candidate vaccine on pregnant sows, and the protective efficacy afforded to their 7-day-old suckling piglets against PRV lethal challenge. Three sows were immunized with rHN-PorPV formulated with immune-stimulating complex (ISCOMs) and two sows with rHN-PorPV protein alone as well as a mock-immunized pregnant sow (negative control). Quantitative ELISA detected a high concentration of anti-rHN-PorPV Immunoglobulin G (IgG) antibodies in sow sera after the second dose of vaccine administered on day 14 until farrowing, showing viral-neutralizing and cross-neutralization activity against different variants of PRV. Sera samples from piglets of immunized sows (with or without adjuvant), showed high concentrations of IgG antibodies. As expected, piglets from the negative control sow (n=5), exhibited severe signs of disease and 100% of mortality after PRV challenge study. Conversely, 75% and 87.5% of the piglets born from the rHN-PorPV and the rHN-PorPV-ISCOMs-immunized sows (n=8), survived, respectively, showing milder PRV clinical signs. Our data indicate that rHN-PorPV candidate vaccine produced in Escherichia coli induces efficient humoral response in pregnant sows and that the maternally derived immunity provides high protection to suckling piglets against PRV lethal challenge.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>36273875</pmid><doi>10.1292/jvms.22-0207</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Veterinary Medical Science, 2022, Vol.84(12), pp.1595-1604 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Animal and Dairy Science Animals Antibodies, Viral Clinical Science Colostrum E coli Enzyme-linked immunosorbent assay Escherichia coli Escherichia coli - genetics Escherichia coli Infections - veterinary Exo-a-sialidase Female hemagglutinin-neuraminidase Hemagglutinins Hogs Husdjursvetenskap Immune response (humoral) immune-stimulating complex Immunogenicity Immunoglobulin G ISCOMS Klinisk vetenskap Neuraminidase - genetics Porcine rubulavirus Pregnancy recombinant vaccine Suckling behavior Swine Swine Diseases Vaccines Viral Proteins Virology |
| title | Immunogenicity of a recombinant hemagglutinin neuraminidase-Porcine rubulavirus produced by Escherichia coli of Porcine rubulavirus gives protective immunity of litter after challenge |
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