Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses
The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, subspecies , establishes a persistent infection in approximately 10 %...
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| Veröffentlicht in: | Microbial genomics 2021-03, Vol.7 (3) |
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| creator | Mitchell, Catriona Steward, Karen F Charbonneau, Amelia R L Walsh, Saoirse Wilson, Hayley Timoney, John F Wernery, Ulli Joseph, Marina Craig, David van Maanen, Kees Hoogkamer-van Gennep, Annelies Leon, Albertine Witkowski, Lucjan Rzewuska, Magdalena Stefańska, Ilona Żychska, Monika van Loon, Gunther Cursons, Ray Patty, Olivia Acke, Els Gilkerson, James R El-Hage, Charles Allen, Joanne Bannai, Hiroshi Kinoshita, Yuta Niwa, Hidekazu Becú, Teótimo Pringle, John Guss, Bengt Böse, Reinhard Abbott, Yvonne Katz, Lisa Leggett, Bernadette Buckley, Tom C Blum, Shlomo E Cruz López, Fátima Fernández Ros, Ana Marotti Campi, Maria Cristina Preziuso, Silvia Robinson, Carl Newton, J Richard Schofield, Ellen Brooke, Ben Boursnell, Mike de Brauwere, Nicolas Kirton, Roxane Barton, Charlotte K Abudahab, Khalil Taylor, Ben Yeats, Corin A Goater, Richard Aanensen, David M Harris, Simon R Parkhill, Julian Holden, Matthew T G Waller, Andrew S |
| description | The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent,
subspecies
, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such 'carrier' animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit
to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of
recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S.
isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of
and its close relative
subspecies
that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact. |
| doi_str_mv | 10.1099/mgen.0.000528 |
| format | Article |
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subspecies
, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such 'carrier' animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit
to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of
recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S.
isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of
and its close relative
subspecies
that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact.</description><identifier>ISSN: 2057-5858</identifier><identifier>EISSN: 2057-5858</identifier><identifier>DOI: 10.1099/mgen.0.000528</identifier><identifier>PMID: 33684029</identifier><language>eng</language><publisher>England: Society for General Microbiology</publisher><subject>Animal biology ; Animals ; Bioresources ; Female ; Genome, Bacterial ; Horse Diseases - microbiology ; Horse Diseases - transmission ; Horses ; Life Sciences ; Male ; Pathobiology ; Patobiologi ; Phylogeny ; Streptococcal Infections - microbiology ; Streptococcal Infections - transmission ; Streptococcal Infections - veterinary ; Streptococcus equi - classification ; Streptococcus equi - genetics ; Streptococcus equi - isolation & purification ; Streptococcus equi - physiology ; Veterinary medicine and animal Health</subject><ispartof>Microbial genomics, 2021-03, Vol.7 (3)</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2021 The Authors 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-794d95d584f3f5bdb592ce0a0de6b3b398caaf05d2b717184ecf922d5d4fb9713</citedby><cites>FETCH-LOGICAL-c526t-794d95d584f3f5bdb592ce0a0de6b3b398caaf05d2b717184ecf922d5d4fb9713</cites><orcidid>0000-0002-9573-5901 ; 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The causal agent,
subspecies
, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such 'carrier' animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit
to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of
recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S.
isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of
and its close relative
subspecies
that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact.</description><subject>Animal biology</subject><subject>Animals</subject><subject>Bioresources</subject><subject>Female</subject><subject>Genome, Bacterial</subject><subject>Horse Diseases - microbiology</subject><subject>Horse Diseases - transmission</subject><subject>Horses</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Pathobiology</subject><subject>Patobiologi</subject><subject>Phylogeny</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - transmission</subject><subject>Streptococcal Infections - veterinary</subject><subject>Streptococcus equi - classification</subject><subject>Streptococcus equi - genetics</subject><subject>Streptococcus equi - isolation & purification</subject><subject>Streptococcus equi - physiology</subject><subject>Veterinary medicine and animal 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strangles: the unbridled national and international transmission of Streptococcus equi between horses</title><author>Mitchell, Catriona ; Steward, Karen F ; Charbonneau, Amelia R L ; Walsh, Saoirse ; Wilson, Hayley ; Timoney, John F ; Wernery, Ulli ; Joseph, Marina ; Craig, David ; van Maanen, Kees ; Hoogkamer-van Gennep, Annelies ; Leon, Albertine ; Witkowski, Lucjan ; Rzewuska, Magdalena ; Stefańska, Ilona ; Żychska, Monika ; van Loon, Gunther ; Cursons, Ray ; Patty, Olivia ; Acke, Els ; Gilkerson, James R ; El-Hage, Charles ; Allen, Joanne ; Bannai, Hiroshi ; Kinoshita, Yuta ; Niwa, Hidekazu ; Becú, Teótimo ; Pringle, John ; Guss, Bengt ; Böse, Reinhard ; Abbott, Yvonne ; Katz, Lisa ; Leggett, Bernadette ; Buckley, Tom C ; Blum, Shlomo E ; Cruz López, Fátima ; Fernández Ros, Ana ; Marotti Campi, Maria Cristina ; Preziuso, Silvia ; Robinson, Carl ; Newton, J Richard ; Schofield, Ellen ; Brooke, Ben ; Boursnell, Mike ; de Brauwere, Nicolas ; Kirton, Roxane ; Barton, Charlotte K ; Abudahab, Khalil ; Taylor, Ben ; Yeats, Corin A ; Goater, Richard ; Aanensen, David M ; Harris, Simon R ; Parkhill, Julian ; Holden, Matthew T G ; Waller, Andrew S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-794d95d584f3f5bdb592ce0a0de6b3b398caaf05d2b717184ecf922d5d4fb9713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal biology</topic><topic>Animals</topic><topic>Bioresources</topic><topic>Female</topic><topic>Genome, Bacterial</topic><topic>Horse Diseases - microbiology</topic><topic>Horse Diseases - transmission</topic><topic>Horses</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Pathobiology</topic><topic>Patobiologi</topic><topic>Phylogeny</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - transmission</topic><topic>Streptococcal Infections - veterinary</topic><topic>Streptococcus equi - classification</topic><topic>Streptococcus equi - genetics</topic><topic>Streptococcus equi - isolation & purification</topic><topic>Streptococcus equi - physiology</topic><topic>Veterinary medicine and animal Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Catriona</creatorcontrib><creatorcontrib>Steward, Karen F</creatorcontrib><creatorcontrib>Charbonneau, Amelia R L</creatorcontrib><creatorcontrib>Walsh, Saoirse</creatorcontrib><creatorcontrib>Wilson, Hayley</creatorcontrib><creatorcontrib>Timoney, John F</creatorcontrib><creatorcontrib>Wernery, Ulli</creatorcontrib><creatorcontrib>Joseph, Marina</creatorcontrib><creatorcontrib>Craig, David</creatorcontrib><creatorcontrib>van Maanen, Kees</creatorcontrib><creatorcontrib>Hoogkamer-van Gennep, Annelies</creatorcontrib><creatorcontrib>Leon, Albertine</creatorcontrib><creatorcontrib>Witkowski, Lucjan</creatorcontrib><creatorcontrib>Rzewuska, Magdalena</creatorcontrib><creatorcontrib>Stefańska, Ilona</creatorcontrib><creatorcontrib>Żychska, Monika</creatorcontrib><creatorcontrib>van Loon, Gunther</creatorcontrib><creatorcontrib>Cursons, Ray</creatorcontrib><creatorcontrib>Patty, Olivia</creatorcontrib><creatorcontrib>Acke, Els</creatorcontrib><creatorcontrib>Gilkerson, James R</creatorcontrib><creatorcontrib>El-Hage, Charles</creatorcontrib><creatorcontrib>Allen, Joanne</creatorcontrib><creatorcontrib>Bannai, Hiroshi</creatorcontrib><creatorcontrib>Kinoshita, Yuta</creatorcontrib><creatorcontrib>Niwa, Hidekazu</creatorcontrib><creatorcontrib>Becú, Teótimo</creatorcontrib><creatorcontrib>Pringle, John</creatorcontrib><creatorcontrib>Guss, Bengt</creatorcontrib><creatorcontrib>Böse, Reinhard</creatorcontrib><creatorcontrib>Abbott, Yvonne</creatorcontrib><creatorcontrib>Katz, Lisa</creatorcontrib><creatorcontrib>Leggett, Bernadette</creatorcontrib><creatorcontrib>Buckley, Tom C</creatorcontrib><creatorcontrib>Blum, Shlomo E</creatorcontrib><creatorcontrib>Cruz López, Fátima</creatorcontrib><creatorcontrib>Fernández Ros, Ana</creatorcontrib><creatorcontrib>Marotti Campi, Maria Cristina</creatorcontrib><creatorcontrib>Preziuso, Silvia</creatorcontrib><creatorcontrib>Robinson, Carl</creatorcontrib><creatorcontrib>Newton, J Richard</creatorcontrib><creatorcontrib>Schofield, Ellen</creatorcontrib><creatorcontrib>Brooke, Ben</creatorcontrib><creatorcontrib>Boursnell, Mike</creatorcontrib><creatorcontrib>de Brauwere, Nicolas</creatorcontrib><creatorcontrib>Kirton, Roxane</creatorcontrib><creatorcontrib>Barton, Charlotte K</creatorcontrib><creatorcontrib>Abudahab, Khalil</creatorcontrib><creatorcontrib>Taylor, Ben</creatorcontrib><creatorcontrib>Yeats, Corin A</creatorcontrib><creatorcontrib>Goater, Richard</creatorcontrib><creatorcontrib>Aanensen, David M</creatorcontrib><creatorcontrib>Harris, Simon R</creatorcontrib><creatorcontrib>Parkhill, Julian</creatorcontrib><creatorcontrib>Holden, Matthew T G</creatorcontrib><creatorcontrib>Waller, Andrew S</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Microbial genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Catriona</au><au>Steward, Karen F</au><au>Charbonneau, Amelia R L</au><au>Walsh, Saoirse</au><au>Wilson, Hayley</au><au>Timoney, John F</au><au>Wernery, Ulli</au><au>Joseph, Marina</au><au>Craig, David</au><au>van Maanen, Kees</au><au>Hoogkamer-van Gennep, Annelies</au><au>Leon, Albertine</au><au>Witkowski, Lucjan</au><au>Rzewuska, Magdalena</au><au>Stefańska, Ilona</au><au>Żychska, Monika</au><au>van Loon, Gunther</au><au>Cursons, Ray</au><au>Patty, Olivia</au><au>Acke, Els</au><au>Gilkerson, James R</au><au>El-Hage, Charles</au><au>Allen, Joanne</au><au>Bannai, Hiroshi</au><au>Kinoshita, Yuta</au><au>Niwa, Hidekazu</au><au>Becú, Teótimo</au><au>Pringle, John</au><au>Guss, Bengt</au><au>Böse, Reinhard</au><au>Abbott, Yvonne</au><au>Katz, Lisa</au><au>Leggett, Bernadette</au><au>Buckley, Tom C</au><au>Blum, Shlomo E</au><au>Cruz López, Fátima</au><au>Fernández Ros, Ana</au><au>Marotti Campi, Maria Cristina</au><au>Preziuso, Silvia</au><au>Robinson, Carl</au><au>Newton, J Richard</au><au>Schofield, Ellen</au><au>Brooke, Ben</au><au>Boursnell, Mike</au><au>de Brauwere, Nicolas</au><au>Kirton, Roxane</au><au>Barton, Charlotte K</au><au>Abudahab, Khalil</au><au>Taylor, Ben</au><au>Yeats, Corin A</au><au>Goater, Richard</au><au>Aanensen, David M</au><au>Harris, Simon R</au><au>Parkhill, Julian</au><au>Holden, Matthew T G</au><au>Waller, Andrew S</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses</atitle><jtitle>Microbial genomics</jtitle><addtitle>Microb Genom</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>7</volume><issue>3</issue><issn>2057-5858</issn><eissn>2057-5858</eissn><abstract>The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent,
subspecies
, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such 'carrier' animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit
to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of
recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S.
isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of
and its close relative
subspecies
that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact.</abstract><cop>England</cop><pub>Society for General Microbiology</pub><pmid>33684029</pmid><doi>10.1099/mgen.0.000528</doi><orcidid>https://orcid.org/0000-0002-9573-5901</orcidid><orcidid>https://orcid.org/0000-0002-7069-5958</orcidid><orcidid>https://orcid.org/0000-0003-4740-9404</orcidid><orcidid>https://orcid.org/0000-0003-1512-6194</orcidid><orcidid>https://orcid.org/0000-0002-4581-9322</orcidid><orcidid>https://orcid.org/0000-0002-7111-9549</orcidid><orcidid>https://orcid.org/0000-0002-0400-2009</orcidid><orcidid>https://orcid.org/0000-0002-2554-8190</orcidid><orcidid>https://orcid.org/0000-0003-0622-7997</orcidid><orcidid>https://orcid.org/0000-0003-1801-4817</orcidid><orcidid>https://orcid.org/0000-0002-0736-8401</orcidid><orcidid>https://orcid.org/0000-0003-4859-1973</orcidid><orcidid>https://orcid.org/0000-0002-2943-6380</orcidid><orcidid>https://orcid.org/0000-0001-9796-7784</orcidid><orcidid>https://orcid.org/0000-0002-2776-273X</orcidid><orcidid>https://orcid.org/0000-0002-6999-2664</orcidid><orcidid>https://orcid.org/0000-0002-5451-9997</orcidid><orcidid>https://orcid.org/0000-0002-4458-9481</orcidid><orcidid>https://orcid.org/0000-0003-4013-0363</orcidid><orcidid>https://orcid.org/0000-0003-4493-8888</orcidid><orcidid>https://orcid.org/0000-0001-5258-6742</orcidid><orcidid>https://orcid.org/0000-0003-0239-9441</orcidid><orcidid>https://orcid.org/0000-0003-2670-6493</orcidid><orcidid>https://orcid.org/0000-0003-0080-6242</orcidid><orcidid>https://orcid.org/0000-0003-0648-1418</orcidid><orcidid>https://orcid.org/0000-0002-1142-3944</orcidid><orcidid>https://orcid.org/0000-0003-1069-3384</orcidid><orcidid>https://orcid.org/0000-0001-9017-292X</orcidid><orcidid>https://orcid.org/0000-0002-7044-0701</orcidid><orcidid>https://orcid.org/0000-0002-4958-2166</orcidid><orcidid>https://orcid.org/0000-0001-9954-841X</orcidid><orcidid>https://orcid.org/0000-0001-6688-0854</orcidid><orcidid>https://orcid.org/0000-0003-3151-4947</orcidid><orcidid>https://orcid.org/0000-0001-5547-2089</orcidid><orcidid>https://orcid.org/0000-0002-9914-2601</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2057-5858 |
| ispartof | Microbial genomics, 2021-03, Vol.7 (3) |
| issn | 2057-5858 2057-5858 |
| language | eng |
| recordid | cdi_swepub_primary_oai_slubar_slu_se_111859 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animal biology Animals Bioresources Female Genome, Bacterial Horse Diseases - microbiology Horse Diseases - transmission Horses Life Sciences Male Pathobiology Patobiologi Phylogeny Streptococcal Infections - microbiology Streptococcal Infections - transmission Streptococcal Infections - veterinary Streptococcus equi - classification Streptococcus equi - genetics Streptococcus equi - isolation & purification Streptococcus equi - physiology Veterinary medicine and animal Health |
| title | Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses |
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