Pesticide Residues in Peri-Urban Bovine Milk from India and Risk Assessment: A Multicenter Study
Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n = 1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to ad...
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| creator | Gill, J. P. S. Bedi, J. S. Singh, Randhir Fairoze, Mohd Nadeem Hazarika, R. A. Gaurav, Abhishek Satpathy, Sudhir Kumar Chauhan, Abhimanyu Singh Lindahl, Johanna Grace, Delia Kumar, Amit Kakkar, Manish |
| description | Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n = 1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to adults and children. Pesticide residues were estimated using gas chromatography with flame thermionic and electron capture detectors followed by confirmation on gas chromatography-mass spectrometer. The results noticed the contamination of milk with hexachlorocyclohexane (HCH), dichloro-diphenyl trichloroethane (DDT), endosulfan, cypermethrin, cyhalothrin, permethrin, chlorpyrifos, ethion and profenophos pesticides. The residue levels in some of the milk samples were observed to be higher than the respective maximum residue limits (MRLs) for pesticide. Milk samples contamination was found highest in Bhubaneswar (11.2%) followed by Bangalore (9.3%), Ludhiana (6.9%), Udaipur (6.4%) and Guwahati (6.3%). The dietary risk assessment of pesticides under two scenarios i.e. lower-bound scenario (LB) and upper-bound (UB) revealed that daily intake of pesticides was substantially below the prescribed acceptable daily intake except for fipronil in children at UB. The non-cancer risk by estimation of hazard index (HI) was found to be below the target value of one in adults at all five sites in India. However, for children at the UB level, the HI for lindane, DDT and ethion exceeded the value of one in Ludhiana and Udaipur. Cancer risk for adults was found to be in the recommended range of United States environment protection agency (USEPA), while it exceeded the USEPA values for children. |
| doi_str_mv | 10.1038/s41598-020-65030-z |
| format | Article |
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P. S. ; Bedi, J. S. ; Singh, Randhir ; Fairoze, Mohd Nadeem ; Hazarika, R. A. ; Gaurav, Abhishek ; Satpathy, Sudhir Kumar ; Chauhan, Abhimanyu Singh ; Lindahl, Johanna ; Grace, Delia ; Kumar, Amit ; Kakkar, Manish</creator><creatorcontrib>Gill, J. P. S. ; Bedi, J. S. ; Singh, Randhir ; Fairoze, Mohd Nadeem ; Hazarika, R. A. ; Gaurav, Abhishek ; Satpathy, Sudhir Kumar ; Chauhan, Abhimanyu Singh ; Lindahl, Johanna ; Grace, Delia ; Kumar, Amit ; Kakkar, Manish ; Sveriges lantbruksuniversitet</creatorcontrib><description>Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n = 1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to adults and children. Pesticide residues were estimated using gas chromatography with flame thermionic and electron capture detectors followed by confirmation on gas chromatography-mass spectrometer. The results noticed the contamination of milk with hexachlorocyclohexane (HCH), dichloro-diphenyl trichloroethane (DDT), endosulfan, cypermethrin, cyhalothrin, permethrin, chlorpyrifos, ethion and profenophos pesticides. The residue levels in some of the milk samples were observed to be higher than the respective maximum residue limits (MRLs) for pesticide. Milk samples contamination was found highest in Bhubaneswar (11.2%) followed by Bangalore (9.3%), Ludhiana (6.9%), Udaipur (6.4%) and Guwahati (6.3%). The dietary risk assessment of pesticides under two scenarios i.e. lower-bound scenario (LB) and upper-bound (UB) revealed that daily intake of pesticides was substantially below the prescribed acceptable daily intake except for fipronil in children at UB. The non-cancer risk by estimation of hazard index (HI) was found to be below the target value of one in adults at all five sites in India. However, for children at the UB level, the HI for lindane, DDT and ethion exceeded the value of one in Ludhiana and Udaipur. Cancer risk for adults was found to be in the recommended range of United States environment protection agency (USEPA), while it exceeded the USEPA values for children.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-65030-z</identifier><identifier>PMID: 32415153</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92 ; 704/172 ; Animals ; Cattle ; Children ; Chlorpyrifos ; Chromatography ; Cow's milk ; Cross-Sectional Studies ; Cyhalothrin ; Cypermethrin ; DDT ; Endosulfan ; Environmental protection ; Environmental Sciences related to Agriculture and Land-use ; Fipronil ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Food Analysis ; Food contamination ; Food Contamination - analysis ; Food Safety ; Gas chromatography ; Health risks ; Hexachlorocyclohexane ; Humanities and Social Sciences ; Humans ; India ; Insecticides ; Lindane ; Miljö- och naturvårdsvetenskap ; Milk ; Milk - chemistry ; multidisciplinary ; Permethrin ; Pesticide residues ; Pesticide Residues - analysis ; Pesticides ; Proportional Hazards Models ; Public Health, Global Health, Social Medicine and Epidemiology ; Risk Assessment ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-05, Vol.10 (1), p.8054, Article 8054</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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P. S.</creatorcontrib><creatorcontrib>Bedi, J. S.</creatorcontrib><creatorcontrib>Singh, Randhir</creatorcontrib><creatorcontrib>Fairoze, Mohd Nadeem</creatorcontrib><creatorcontrib>Hazarika, R. A.</creatorcontrib><creatorcontrib>Gaurav, Abhishek</creatorcontrib><creatorcontrib>Satpathy, Sudhir Kumar</creatorcontrib><creatorcontrib>Chauhan, Abhimanyu Singh</creatorcontrib><creatorcontrib>Lindahl, Johanna</creatorcontrib><creatorcontrib>Grace, Delia</creatorcontrib><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Kakkar, Manish</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><title>Pesticide Residues in Peri-Urban Bovine Milk from India and Risk Assessment: A Multicenter Study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n = 1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to adults and children. Pesticide residues were estimated using gas chromatography with flame thermionic and electron capture detectors followed by confirmation on gas chromatography-mass spectrometer. The results noticed the contamination of milk with hexachlorocyclohexane (HCH), dichloro-diphenyl trichloroethane (DDT), endosulfan, cypermethrin, cyhalothrin, permethrin, chlorpyrifos, ethion and profenophos pesticides. The residue levels in some of the milk samples were observed to be higher than the respective maximum residue limits (MRLs) for pesticide. Milk samples contamination was found highest in Bhubaneswar (11.2%) followed by Bangalore (9.3%), Ludhiana (6.9%), Udaipur (6.4%) and Guwahati (6.3%). The dietary risk assessment of pesticides under two scenarios i.e. lower-bound scenario (LB) and upper-bound (UB) revealed that daily intake of pesticides was substantially below the prescribed acceptable daily intake except for fipronil in children at UB. The non-cancer risk by estimation of hazard index (HI) was found to be below the target value of one in adults at all five sites in India. However, for children at the UB level, the HI for lindane, DDT and ethion exceeded the value of one in Ludhiana and Udaipur. Cancer risk for adults was found to be in the recommended range of United States environment protection agency (USEPA), while it exceeded the USEPA values for children.</description><subject>631/92</subject><subject>704/172</subject><subject>Animals</subject><subject>Cattle</subject><subject>Children</subject><subject>Chlorpyrifos</subject><subject>Chromatography</subject><subject>Cow's milk</subject><subject>Cross-Sectional Studies</subject><subject>Cyhalothrin</subject><subject>Cypermethrin</subject><subject>DDT</subject><subject>Endosulfan</subject><subject>Environmental protection</subject><subject>Environmental Sciences related to Agriculture and Land-use</subject><subject>Fipronil</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>Food Analysis</subject><subject>Food contamination</subject><subject>Food Contamination - analysis</subject><subject>Food Safety</subject><subject>Gas chromatography</subject><subject>Health risks</subject><subject>Hexachlorocyclohexane</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>India</subject><subject>Insecticides</subject><subject>Lindane</subject><subject>Miljö- och naturvårdsvetenskap</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>multidisciplinary</subject><subject>Permethrin</subject><subject>Pesticide residues</subject><subject>Pesticide Residues - analysis</subject><subject>Pesticides</subject><subject>Proportional Hazards Models</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Risk Assessment</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNp9UU1P3DAQtaoiQMAf4FBZ6rWh449k4x4qbekHSKAiWnp17XiyNWQdaidU8OvxsguFA_gytua9N573CNllsMdA1O-TZKWqC-BQVCUIKG5ekU0Osiy44Pz1o_sG2UnpHPIpuZJMrZMNwTOblWKT_D7BNPjGO6SnmLwbMVEf6AlGX5xFawL91F_5gPTYdxe0jf2cHgbnDTXB0VOfLug0JUxpjmH4QKf0eOyyXH5gpD-G0V1vk7XWdAl3VnWLnH398nP_oDj6_u1wf3pUNBWIoajbGq2zglW2bqq6KbEVbdO4CTPMSDDWMOlaYKwStrSV4hmvpFIOai6UnYgtsrfUTf_wcrT6Mvq5ide6N16nbrQmLopOqBlMFFSZ8O5Zwmf_a6r7ONPjqCXPRqkM_7iEZ-wc3WLFaLonrKed4P_oWX-lJ5wrkCILvF0JxP5vtnnQ5_0YQ_ZEcwlCAINKZhRfoprYpxSxfZjAQC-C18vgdQ5e3wWvbzLpzeO_PVDuY84Asdo1t8IM4__ZL8jeAnnIuwI</recordid><startdate>20200515</startdate><enddate>20200515</enddate><creator>Gill, J. 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P. S.</au><au>Bedi, J. S.</au><au>Singh, Randhir</au><au>Fairoze, Mohd Nadeem</au><au>Hazarika, R. A.</au><au>Gaurav, Abhishek</au><au>Satpathy, Sudhir Kumar</au><au>Chauhan, Abhimanyu Singh</au><au>Lindahl, Johanna</au><au>Grace, Delia</au><au>Kumar, Amit</au><au>Kakkar, Manish</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pesticide Residues in Peri-Urban Bovine Milk from India and Risk Assessment: A Multicenter Study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-05-15</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>8054</spage><pages>8054-</pages><artnum>8054</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Pesticides residue poses serious concerns to human health. The present study was carried out to determine the pesticide residues of peri-urban bovine milk (n = 1183) from five different sites (Bangalore, Bhubaneswar, Guwahati, Ludhiana and Udaipur) in India and dietary exposure risk assessment to adults and children. Pesticide residues were estimated using gas chromatography with flame thermionic and electron capture detectors followed by confirmation on gas chromatography-mass spectrometer. The results noticed the contamination of milk with hexachlorocyclohexane (HCH), dichloro-diphenyl trichloroethane (DDT), endosulfan, cypermethrin, cyhalothrin, permethrin, chlorpyrifos, ethion and profenophos pesticides. The residue levels in some of the milk samples were observed to be higher than the respective maximum residue limits (MRLs) for pesticide. Milk samples contamination was found highest in Bhubaneswar (11.2%) followed by Bangalore (9.3%), Ludhiana (6.9%), Udaipur (6.4%) and Guwahati (6.3%). The dietary risk assessment of pesticides under two scenarios i.e. lower-bound scenario (LB) and upper-bound (UB) revealed that daily intake of pesticides was substantially below the prescribed acceptable daily intake except for fipronil in children at UB. The non-cancer risk by estimation of hazard index (HI) was found to be below the target value of one in adults at all five sites in India. However, for children at the UB level, the HI for lindane, DDT and ethion exceeded the value of one in Ludhiana and Udaipur. Cancer risk for adults was found to be in the recommended range of United States environment protection agency (USEPA), while it exceeded the USEPA values for children.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32415153</pmid><doi>10.1038/s41598-020-65030-z</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/92 704/172 Animals Cattle Children Chlorpyrifos Chromatography Cow's milk Cross-Sectional Studies Cyhalothrin Cypermethrin DDT Endosulfan Environmental protection Environmental Sciences related to Agriculture and Land-use Fipronil Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Food Analysis Food contamination Food Contamination - analysis Food Safety Gas chromatography Health risks Hexachlorocyclohexane Humanities and Social Sciences Humans India Insecticides Lindane Miljö- och naturvårdsvetenskap Milk Milk - chemistry multidisciplinary Permethrin Pesticide residues Pesticide Residues - analysis Pesticides Proportional Hazards Models Public Health, Global Health, Social Medicine and Epidemiology Risk Assessment Science Science (multidisciplinary) |
| title | Pesticide Residues in Peri-Urban Bovine Milk from India and Risk Assessment: A Multicenter Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T12%3A40%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pesticide%20Residues%20in%20Peri-Urban%20Bovine%20Milk%20from%20India%20and%20Risk%20Assessment:%20A%20Multicenter%20Study&rft.jtitle=Scientific%20reports&rft.au=Gill,%20J.%20P.%20S.&rft.aucorp=Sveriges%20lantbruksuniversitet&rft.date=2020-05-15&rft.volume=10&rft.issue=1&rft.spage=8054&rft.pages=8054-&rft.artnum=8054&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-65030-z&rft_dat=%3Cproquest_swepu%3E2403301064%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2403301064&rft_id=info:pmid/32415153&rfr_iscdi=true |