Testosterone exposure, dopaminergic reward, and sensation-seeking in young men
Abstract To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor ( DRD4 ) genes from 98 young...
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| Veröffentlicht in: | Physiology & behavior 2010-03, Vol.99 (4), p.451-456 |
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| creator | Campbell, Benjamin C Dreber, Anna Apicella, Coren L Eisenberg, Dan T.A Gray, Peter B Little, Anthony C Garcia, Justin R Zamore, Richard S Lum, J. Koji |
| description | Abstract To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor ( DRD4 ) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between T and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking. |
| doi_str_mv | 10.1016/j.physbeh.2009.12.011 |
| format | Article |
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Koji</creator><creatorcontrib>Campbell, Benjamin C ; Dreber, Anna ; Apicella, Coren L ; Eisenberg, Dan T.A ; Gray, Peter B ; Little, Anthony C ; Garcia, Justin R ; Zamore, Richard S ; Lum, J. Koji</creatorcontrib><description>Abstract To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor ( DRD4 ) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between T and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2009.12.011</identifier><identifier>PMID: 20026092</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Age ; Androgens - pharmacology ; Behavioral psychophysiology ; Biological and medical sciences ; Dopamine - metabolism ; Dopaminergic reward system ; DRD4 ; Face ; Fingers - physiology ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Male ; Masculinity ; Minisatellite Repeats - genetics ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Receptors, Dopamine D4 - genetics ; Reward ; Risk-Taking ; Saliva - metabolism ; Sensation - drug effects ; Sensation-seeking ; Testosterone ; Testosterone - metabolism ; Testosterone - pharmacology ; Young Adult</subject><ispartof>Physiology & behavior, 2010-03, Vol.99 (4), p.451-456</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-814c5d635f8b5531e4e5c73109fca5d1d3c252ef38b090902df636c2c9f17dda3</citedby><cites>FETCH-LOGICAL-c523t-814c5d635f8b5531e4e5c73109fca5d1d3c252ef38b090902df636c2c9f17dda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938409003977$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22496506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20026092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://research.hhs.se/esploro/outputs/journalArticle/Testosterone-exposure-dopaminergic-reward-and-sensation-seeking/991001480988506056$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, Benjamin C</creatorcontrib><creatorcontrib>Dreber, Anna</creatorcontrib><creatorcontrib>Apicella, Coren L</creatorcontrib><creatorcontrib>Eisenberg, Dan T.A</creatorcontrib><creatorcontrib>Gray, Peter B</creatorcontrib><creatorcontrib>Little, Anthony C</creatorcontrib><creatorcontrib>Garcia, Justin R</creatorcontrib><creatorcontrib>Zamore, Richard S</creatorcontrib><creatorcontrib>Lum, J. Koji</creatorcontrib><title>Testosterone exposure, dopaminergic reward, and sensation-seeking in young men</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Abstract To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor ( DRD4 ) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between T and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking.</description><subject>Adolescent</subject><subject>Age</subject><subject>Androgens - pharmacology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic reward system</subject><subject>DRD4</subject><subject>Face</subject><subject>Fingers - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Masculinity</subject><subject>Minisatellite Repeats - genetics</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Receptors, Dopamine D4 - genetics</subject><subject>Reward</subject><subject>Risk-Taking</subject><subject>Saliva - metabolism</subject><subject>Sensation - drug effects</subject><subject>Sensation-seeking</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>Testosterone - pharmacology</subject><subject>Young Adult</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhJ4ByQVya4LHjfFxAqIIWqYIDReJmOfak6-2uHTwJZf89jnYpEpfaB8_heefD72TZS2AlMKjfbspxvace1yVnrCuBlwzgUbaCthGFZM2Px9mKMQFFJ9rqJHtGtGHpiEo8zU6ShNes46vsyzXSFGjCGDzm-HsMNEc8y20Y9c55jDfO5BHvdLRnufY2J_SkJxd8QYi3zt_kzuf7MKdgh_559mTQW8IXx_c0-_7p4_X5ZXH19eLz-YerwkgupqKFykhbCzm0vZQCsEJpGgGsG4yWFqwwXHIcRNuzLl1uh1rUhptugMZaLU4zOOSlOxznXo3R7XTcq6CdWq9JESoAKaFqoU5T10zWSfPmoBlj-DmnsdXOkcHtVnsMM6mmSpBsZPcwKUSVMnYLKQ-kiYEo4nDfCTC1-KQ26uiTWnxSwFXyKeleHSvM_Q7tveqvMQl4fQQ0Gb0dovbG0T-OV10t2TLU-wOH6bd_OYyKjENv0LqIZlI2uAdbefdfBrN13qWit7hH2oQ5-mSlAkVJoL4tS7XsVLKFia5pxB9pTscW</recordid><startdate>20100330</startdate><enddate>20100330</enddate><creator>Campbell, Benjamin C</creator><creator>Dreber, Anna</creator><creator>Apicella, Coren L</creator><creator>Eisenberg, Dan T.A</creator><creator>Gray, Peter B</creator><creator>Little, Anthony C</creator><creator>Garcia, Justin R</creator><creator>Zamore, Richard S</creator><creator>Lum, J. Koji</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100330</creationdate><title>Testosterone exposure, dopaminergic reward, and sensation-seeking in young men</title><author>Campbell, Benjamin C ; Dreber, Anna ; Apicella, Coren L ; Eisenberg, Dan T.A ; Gray, Peter B ; Little, Anthony C ; Garcia, Justin R ; Zamore, Richard S ; Lum, J. Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-814c5d635f8b5531e4e5c73109fca5d1d3c252ef38b090902df636c2c9f17dda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Androgens - pharmacology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic reward system</topic><topic>DRD4</topic><topic>Face</topic><topic>Fingers - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Masculinity</topic><topic>Minisatellite Repeats - genetics</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Receptors, Dopamine D4 - genetics</topic><topic>Reward</topic><topic>Risk-Taking</topic><topic>Saliva - metabolism</topic><topic>Sensation - drug effects</topic><topic>Sensation-seeking</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>Testosterone - pharmacology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, Benjamin C</creatorcontrib><creatorcontrib>Dreber, Anna</creatorcontrib><creatorcontrib>Apicella, Coren L</creatorcontrib><creatorcontrib>Eisenberg, Dan T.A</creatorcontrib><creatorcontrib>Gray, Peter B</creatorcontrib><creatorcontrib>Little, Anthony C</creatorcontrib><creatorcontrib>Garcia, Justin R</creatorcontrib><creatorcontrib>Zamore, Richard S</creatorcontrib><creatorcontrib>Lum, J. 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Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testosterone exposure, dopaminergic reward, and sensation-seeking in young men</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2010-03-30</date><risdate>2010</risdate><volume>99</volume><issue>4</issue><spage>451</spage><epage>456</epage><pages>451-456</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Abstract To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor ( DRD4 ) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between T and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20026092</pmid><doi>10.1016/j.physbeh.2009.12.011</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Age Androgens - pharmacology Behavioral psychophysiology Biological and medical sciences Dopamine - metabolism Dopaminergic reward system DRD4 Face Fingers - physiology Fundamental and applied biological sciences. Psychology Genotype Humans Male Masculinity Minisatellite Repeats - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Dopamine D4 - genetics Reward Risk-Taking Saliva - metabolism Sensation - drug effects Sensation-seeking Testosterone Testosterone - metabolism Testosterone - pharmacology Young Adult |
| title | Testosterone exposure, dopaminergic reward, and sensation-seeking in young men |
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