Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation

The prevention of stroke and restenosis of coronary arteries in patients with atrial fibrillation who have an acute coronary syndrome or undergo percutaneous coronary intervention relies on antithrombotic therapy. In a two-by-two factorial, randomized trial, apixaban plus clopidogrel was more effect...

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Veröffentlicht in:	The New England journal of medicine 2019-04, Vol.380 (16), p.1509-1524
Hauptverfasser:	Lopes, Renato D, Heizer, Gretchen, Aronson, Ronald, Vora, Amit N, Massaro, Tyler, Mehran, Roxana, Goodman, Shaun G, Windecker, Stephan, Darius, Harald, Li, Jia, Averkov, Oleg, Bahit, M. Cecilia, Berwanger, Otavio, Budaj, Andrzej, Hijazi, Ziad, Parkhomenko, Alexander, Sinnaeve, Peter, Storey, Robert F, Thiele, Holger, Vinereanu, Dragos, Granger, Christopher B, Alexander, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - complications Acute Coronary Syndrome - therapy Acute coronary syndromes Aged Aged, 80 and over Anticoagulants Anticoagulants - adverse effects Anticoagulants - therapeutic use Aspirin Aspirin - adverse effects Aspirin - therapeutic use Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Bleeding Cardiac arrhythmia Clinical outcomes Death Disease management Double-Blind Method Drug Therapy, Combination Electrocardiography Factor Xa Inhibitors - adverse effects Factor Xa Inhibitors - therapeutic use Female Fibrillation Hemorrhage - chemically induced Humans Ischemia Male Middle Aged Percutaneous Coronary Intervention Platelet Aggregation Inhibitors - therapeutic use Purinergic P2Y Receptor Antagonists - therapeutic use Pyrazoles - adverse effects Pyrazoles - therapeutic use Pyridones - adverse effects Pyridones - therapeutic use Stroke Vitamin K Vitamin K - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	The prevention of stroke and restenosis of coronary arteries in patients with atrial fibrillation who have an acute coronary syndrome or undergo percutaneous coronary intervention relies on antithrombotic therapy. In a two-by-two factorial, randomized trial, apixaban plus clopidogrel was more effective than a vitamin K antagonist, with or without aspirin.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1817083