Temporal association of infant immunisation with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonisation in a rural South African community

Highlights • PCV immunisation at 6, 10 and 40 weeks, with no catch-up campaign, reduces vaccine serotype colonisation in infants. • Also, community-wide reduction in vaccine serotype colonisation observed among adults with a high HIV prevalence. • Temporal reduction in H. influenzae colonisation amo...

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Veröffentlicht in:	Vaccine 2014-09, Vol.32 (42), p.5520-5530
Hauptverfasser:	Nzenze, S.A, Shiri, T, Nunes, M.C, Klugman, K.P, Kahn, K, Twine, R, de Gouveia, L, von Gottberg, A, Madhi, S.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Applied microbiology Bacteriology Biological and medical sciences Carrier State - epidemiology Child Child, Preschool Cross-Sectional Studies Female Fundamental and applied biological sciences. Psychology Haemophilus influenzae Haemophilus influenzae - isolation & purification Heptavalent Pneumococcal Conjugate Vaccine Humans Infant Infant immunisation Infant, Newborn Male Microbiology Middle Aged Miscellaneous Nasopharyngeal colonisation Nasopharynx - microbiology Pneumococcal conjugate vaccine Pneumococcal Infections - prevention & control Pneumococcal Vaccines - therapeutic use Rural Population South Africa - epidemiology Staphylococcus aureus Staphylococcus aureus - isolation & purification Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Time Factors Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Conjugate - therapeutic use Young Adult
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Beschreibung
Zusammenfassung:	Highlights • PCV immunisation at 6, 10 and 40 weeks, with no catch-up campaign, reduces vaccine serotype colonisation in infants. • Also, community-wide reduction in vaccine serotype colonisation observed among adults with a high HIV prevalence. • Temporal reduction in H. influenzae colonisation among children targeted for vaccination. • No changes in prevalence of S. aureus colonisation in children, whilst showing temporal decline in adults.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2014.06.091