Fasting apolipoprotein B48 is a marker for peripheral arterial disease in type 2 diabetes

An earlier study showed that fasting and postprandial concentrations of apolipoprotein B48 were raised in patients with type 2 diabetes (DM2) and peripheral arterial disease (PAD) as compared with persons without DM2 or persons with DM2 but not PAD. The aim of this study was to confirm the associati...

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Veröffentlicht in:	Acta diabetologica 2013-06, Vol.50 (3), p.383-389
Hauptverfasser:	Mancera-Romero, J., Sánchez-Chaparro, M. A., Rioja, J., Ariza, M. J., Olivecrona, G., González-Santos, P., Valdivielso, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Ankle Brachial Index Apolipoprotein B-48 - blood Apolipoprotein B48 Apolipoproteins E - genetics Biomarkers Biomarkers - blood Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetic Angiopathies - drug therapy Diabetic Angiopathies - metabolism Fasting Female Genotype Humans Hypoglycemic Agents - therapeutic use Hypolipidemic Agents - therapeutic use Insulin - therapeutic use Internal Medicine Lipoprotein Lipase - blood LPL mass Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Peripheral arterial disease Peripheral Arterial Disease - drug therapy Peripheral Arterial Disease - etiology Peripheral Arterial Disease - metabolism Proteins Type 2 diabetes
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Zusammenfassung:	An earlier study showed that fasting and postprandial concentrations of apolipoprotein B48 were raised in patients with type 2 diabetes (DM2) and peripheral arterial disease (PAD) as compared with persons without DM2 or persons with DM2 but not PAD. The aim of this study was to confirm the association of PAD and B48 in a larger group of patients with DM2 and the relation of B48 with the preheparin lipoprotein lipase (LPL) mass. We studied 456 patients with DM2. PAD was defined as an ankle-brachial index (ABI)
ISSN:	0940-5429 1432-5233 1432-5233
DOI:	10.1007/s00592-012-0434-x