NanoKeepers: stimuli responsive nanocapsules for programmed specific targeting and drug delivery

Bacterial resistance is a high priority clinical issue worldwide. Thus, an effective system that rapidly provides specific treatment for bacterial infections using controlled dose release remains an unmet clinical need. Herein, we report on the NanoKeepers approach for the specific targeting of S. a...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (67), p.9489-9492
Hauptverfasser:	Hernandez, Frank J, Hernandez, Luiza I, Kavruk, Murat, Arıca, Yakup M, Bayramoğlu, Gülay, Borsa, Baris A, Öktem, Hüseyin A, Schäfer, Thomas, Özalp, Veli C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Control systems Controlled release Delayed-Action Preparations Drug Carriers - chemistry Drug delivery systems Medical services Micrococcal Nuclease - metabolism Models, Molecular Molecular Conformation Nanocapsules - chemistry Nanostructure Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects Stimuli Vancomycin - chemistry Vancomycin - metabolism Vancomycin - pharmacology
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Beschreibung
Zusammenfassung:	Bacterial resistance is a high priority clinical issue worldwide. Thus, an effective system that rapidly provides specific treatment for bacterial infections using controlled dose release remains an unmet clinical need. Herein, we report on the NanoKeepers approach for the specific targeting of S. aureus with controlled release of antibiotics based on nuclease activity.
ISSN:	1359-7345 1364-548X 1364-548X
DOI:	10.1039/c4cc04248d