Fluorescence-Lifetime Imaging of DNA-Dye Interactions within Continuous-Flow Microfluidic Systems

Fluorescence-Lifetime Imaging of DNA-Dye Interactions within Continuous-Flow Microfluidic Systems

Light across the channel: The utility of time‐resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA–dye binding interactions. The combination of time‐resolved fluorescence imaging and continuous‐flow microfluidics provides a powerful route...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (13), p.2228-2231
Hauptverfasser: Benninger, Richard K. P., Hofmann, Oliver, Önfelt, Björn, Munro, Ian, Dunsby, Chris, Davis, Daniel M., Neil, Mark A. A., French, Paul M. W., de Mello, Andrew J.
Format: Artikel
Sprache:eng
Schlagworte:
chip
devices
DNA - chemistry
Fluorescence
Fluorescent Dyes - chemistry
imaging
intercalation
kinetics
microchannel
microfluidics
Microfluidics - instrumentation
Microfluidics - methods
microreactors
networks
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Beschreibung
Zusammenfassung:Light across the channel: The utility of time‐resolved fluorescence imaging as a detection modality for microfluidic systems has been extended by a study of DNA–dye binding interactions. The combination of time‐resolved fluorescence imaging and continuous‐flow microfluidics provides a powerful route to the resolution and quantification of multistate biological systems with precise spatial and temporal reaction control.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200604112