Prediction Efficacy for Clinical Outcome of Prognostic Nutritional Index in Patients with Resectable Biliary Tract Cancer Depends on Sex and Obstructive Jaundice Status

Prediction Efficacy for Clinical Outcome of Prognostic Nutritional Index in Patients with Resectable Biliary Tract Cancer Depends on Sex and Obstructive Jaundice Status

Background The Prognostic Nutritional Index (PNI), a marker of nutritional status and systemic inflammation, is a proven prognostic biomarker in some cancers. The predictive value of PNI in biliary tract cancer (BTC) has not been established. Objective The aim of this study was to determine the rela...

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Veröffentlicht in:Annals of surgical oncology 2021, Vol.28 (1), p.430-438
Hauptverfasser: Wang, Jie, Bo, Xiaobo, Li, Min, Nan, Lingxi, Wang, Changcheng, Gao, Zhihui, Suo, Tao, Ni, Xiaoling, Liu, Han, Han, Jun, Lu, Pinxiang, Liu, Houbao, Wang, Yueqi
Format: Artikel
Sprache:eng
Schlagworte:
Bile Ducts, Intrahepatic - pathology
Biliary tract
Biliary Tract Neoplasms - diagnosis
Biliary Tract Neoplasms - pathology
Cancer
Cholangiocarcinoma
Female
Gallbladder cancer
Hepatobiliary Tumors
Humans
Jaundice
Jaundice, Obstructive - diagnosis
Jaundice, Obstructive - pathology
Life Sciences & Biomedicine
Male
Medicine
Medicine & Public Health
Multivariate analysis
Nutrition Assessment
Nutritional Status
Oncology
Patients
Prognosis
Retrospective Studies
Risk factors
Science & Technology
Sex Factors
Surgery
Surgical Oncology
Survival
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Zusammenfassung:Background The Prognostic Nutritional Index (PNI), a marker of nutritional status and systemic inflammation, is a proven prognostic biomarker in some cancers. The predictive value of PNI in biliary tract cancer (BTC) has not been established. Objective The aim of this study was to determine the relationship between the PNI and outcomes of resectable BTC. Methods In total, 430 patients with stage I–III resectable BTC [gallbladder cancer (GBC), n  = 212; cholangiocarcinoma (CHO), n  = 218] who had attended Fudan University Zhongshan Hospital were enrolled. The relationship between the PNI and clinical outcomes was evaluated both in the whole cohort and in selected subgroups. Results Eligible patients were classified into PNI-low (PNI 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08728-8