Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News & Commentary

Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News & Commentary

Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular psychiatry 1998-05, Vol.3 (3), p.192-195
Hauptverfasser: Reynolds, G P, Dalton, C F
Format: Artikel
Sprache:eng
Schlagworte:
Behavioral Sciences
Biological Psychology
Medicine
Medicine & Public Health
Neurosciences
news-and-commentary
Pharmacotherapy
Psychiatry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 195
container_issue 3
container_start_page 192
container_title Molecular psychiatry
container_volume 3
creator Reynolds, G P
Dalton, C F
description Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.
doi_str_mv 10.1038/sj.mp.4000374
format Article
fullrecord <record><control><sourceid>springer</sourceid><recordid>TN_cdi_springer_journals_10_1038_sj_mp_4000374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1038_sj_mp_4000374</sourcerecordid><originalsourceid>FETCH-springer_journals_10_1038_sj_mp_40003743</originalsourceid><addsrcrecordid>eNqVjz1OxDAQhS0EEstPST8dVbK24pBQUSDQHmB7y2wGJ5Ezjjy20HYcghNyErzSXoDqfdL3XvGEeFCyVrLptzzXy1prKWXT6QuxUbp7qtq26y8LN-1zpVWvr8UN8yzlSbYbMe6jJXZI0wGWMKBnsDQA548Dep-9jbDaNAYf3BF-v39gCJBGPEIqGjLD12gTuICFYiAHE8EuU5rIpUCPDMPEaBlf7sTVp_WM9-e8FfX72_51V_EaSxmjmUOOVJRR0pz-GJ7Nsprzn-bfgz9QSVaI</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News &amp; Commentary</title><source>SpringerLink Journals</source><creator>Reynolds, G P ; Dalton, C F</creator><creatorcontrib>Reynolds, G P ; Dalton, C F</creatorcontrib><description>Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4000374</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Behavioral Sciences ; Biological Psychology ; Medicine ; Medicine &amp; Public Health ; Neurosciences ; news-and-commentary ; Pharmacotherapy ; Psychiatry</subject><ispartof>Molecular psychiatry, 1998-05, Vol.3 (3), p.192-195</ispartof><rights>Macmillan Publishers Limited 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4000374$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4000374$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Reynolds, G P</creatorcontrib><creatorcontrib>Dalton, C F</creatorcontrib><title>Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News &amp; Commentary</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><description>Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.</description><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neurosciences</subject><subject>news-and-commentary</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVjz1OxDAQhS0EEstPST8dVbK24pBQUSDQHmB7y2wGJ5Ezjjy20HYcghNyErzSXoDqfdL3XvGEeFCyVrLptzzXy1prKWXT6QuxUbp7qtq26y8LN-1zpVWvr8UN8yzlSbYbMe6jJXZI0wGWMKBnsDQA548Dep-9jbDaNAYf3BF-v39gCJBGPEIqGjLD12gTuICFYiAHE8EuU5rIpUCPDMPEaBlf7sTVp_WM9-e8FfX72_51V_EaSxmjmUOOVJRR0pz-GJ7Nsprzn-bfgz9QSVaI</recordid><startdate>19980501</startdate><enddate>19980501</enddate><creator>Reynolds, G P</creator><creator>Dalton, C F</creator><general>Nature Publishing Group UK</general><scope/></search><sort><creationdate>19980501</creationdate><title>Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?</title><author>Reynolds, G P ; Dalton, C F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-springer_journals_10_1038_sj_mp_40003743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Neurosciences</topic><topic>news-and-commentary</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reynolds, G P</creatorcontrib><creatorcontrib>Dalton, C F</creatorcontrib><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reynolds, G P</au><au>Dalton, C F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News &amp; Commentary</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><date>1998-05-01</date><risdate>1998</risdate><volume>3</volume><issue>3</issue><spage>192</spage><epage>195</epage><pages>192-195</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/sj.mp.4000374</doi></addata></record>
fulltext fulltext
identifier ISSN: 1359-4184
ispartof Molecular psychiatry, 1998-05, Vol.3 (3), p.192-195
issn 1359-4184
1476-5578
language eng
recordid cdi_springer_journals_10_1038_sj_mp_4000374
source SpringerLink Journals
subjects Behavioral Sciences
Biological Psychology
Medicine
Medicine & Public Health
Neurosciences
news-and-commentary
Pharmacotherapy
Psychiatry
title Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News & Commentary
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T10%3A23%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-springer&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transgenic%20models%20and%20subcellular%20pathology%20%E2%80%94%20do%20they%20tell%20us%20what%20goes%20wrong%20in%20Huntington's%20disease?:%20News%20&%20Commentary&rft.jtitle=Molecular%20psychiatry&rft.au=Reynolds,%20G%20P&rft.date=1998-05-01&rft.volume=3&rft.issue=3&rft.spage=192&rft.epage=195&rft.pages=192-195&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/sj.mp.4000374&rft_dat=%3Cspringer%3E10_1038_sj_mp_4000374%3C/springer%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true