Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News & Commentary

Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?: News & Commentary

Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:Molecular psychiatry 1998-05, Vol.3 (3), p.192-195
Hauptverfasser: Reynolds, G P, Dalton, C F
Format: Artikel
Sprache:eng
Schlagworte:
Behavioral Sciences
Biological Psychology
Medicine
Medicine & Public Health
Neurosciences
news-and-commentary
Pharmacotherapy
Psychiatry
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Beschreibung
Zusammenfassung:Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.
ISSN:1359-4184
1476-5578
DOI:10.1038/sj.mp.4000374