FLT3 regulates β-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells: Oncogenes, Fusion Genes and Tumor Suppressor Genes

Deregulated accumulation of nuclear β-catenin enhances transcription of β-catenin target genes and promotes malignant transformation. Recently, acute myeloid leukemia (AML) cells with activating mutations of FMS-like tyrosine kinase-3 (FLT3) were reported to display elevated β-catenin-dependent nucl...

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Veröffentlicht in:	Leukemia 2007, Vol.21 (12), p.2476-2484
Hauptverfasser:	Kajiguchi, T, Chung, E J, Lee, S, Stine, A, Kiyoi, H, Naoe, T, Levis, M J, Neckers, L, Trepel, J B
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Research Critical Care Medicine Hematology Intensive Internal Medicine Medicine Medicine & Public Health Oncology original-article
Online-Zugang:	Volltext
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