In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation: Endothelial Colonies
The distribution and functional characteristics of in vitro bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2003-12, Vol.32 (12), p.1165-1173 |
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| container_title | Bone marrow transplantation (Basingstoke) |
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| creator | Lanza, F Campioni, D Punturieri, M Moretti, S Dabusti, M Spanedda, R Castoldi, G |
| description | The distribution and functional characteristics of
in vitro
bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10
6
BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (
P
=0.04), and in normal subjects (
P
=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (
P
=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4–6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte–macrophage (CFU-GM) (
P
=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (
P
=0.044). These
in vitro
data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function. |
| doi_str_mv | 10.1038/sj.bmt.1704279 |
| format | Article |
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in vitro
bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10
6
BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (
P
=0.04), and in normal subjects (
P
=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (
P
=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4–6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte–macrophage (CFU-GM) (
P
=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (
P
=0.044). These
in vitro
data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1704279</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Cell Biology ; Hematology ; Internal Medicine ; Medicine ; Medicine & Public Health ; original-article ; Public Health ; Stem Cells</subject><ispartof>Bone marrow transplantation (Basingstoke), 2003-12, Vol.32 (12), p.1165-1173</ispartof><rights>Springer Nature Limited 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lanza, F</creatorcontrib><creatorcontrib>Campioni, D</creatorcontrib><creatorcontrib>Punturieri, M</creatorcontrib><creatorcontrib>Moretti, S</creatorcontrib><creatorcontrib>Dabusti, M</creatorcontrib><creatorcontrib>Spanedda, R</creatorcontrib><creatorcontrib>Castoldi, G</creatorcontrib><title>In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation: Endothelial Colonies</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>The distribution and functional characteristics of
in vitro
bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10
6
BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (
P
=0.04), and in normal subjects (
P
=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (
P
=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4–6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte–macrophage (CFU-GM) (
P
=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (
P
=0.044). These
in vitro
data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function.</description><subject>Cell Biology</subject><subject>Hematology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>original-article</subject><subject>Public Health</subject><subject>Stem Cells</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVkLtOw0AQRVcIJMyjpZ4OKOys41dSR4lCD7W1jif2mvWMtbMB8Sn8LUbKD6S6xdU5xVHqKdVJqrPVQoakGUOSVjpfVusrFaV5VcZFVhbXKtLLchVnWbm-VXcig9ZpnusiUr9vBF82eAYjgiIjUgA-QsOEMBrv-RuQWg49OmscHNgxWRR42ew-4i29giUgpnjPbfdp6VnA_YxTz6OByQQ76wRO1KLv2FIHE3o79ehnVeOYW5CAIxzQOQjekEzOUJg5pgd1czRO8PG892qx275v9rFMfjahrwc-eZqvOtX1f4FahnouUJ8LZJcTf8huaZ8</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Lanza, F</creator><creator>Campioni, D</creator><creator>Punturieri, M</creator><creator>Moretti, S</creator><creator>Dabusti, M</creator><creator>Spanedda, R</creator><creator>Castoldi, G</creator><general>Nature Publishing Group UK</general><scope/></search><sort><creationdate>20031201</creationdate><title>In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation</title><author>Lanza, F ; Campioni, D ; Punturieri, M ; Moretti, S ; Dabusti, M ; Spanedda, R ; Castoldi, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-springer_journals_10_1038_sj_bmt_17042793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Cell Biology</topic><topic>Hematology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>original-article</topic><topic>Public Health</topic><topic>Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lanza, F</creatorcontrib><creatorcontrib>Campioni, D</creatorcontrib><creatorcontrib>Punturieri, M</creatorcontrib><creatorcontrib>Moretti, S</creatorcontrib><creatorcontrib>Dabusti, M</creatorcontrib><creatorcontrib>Spanedda, R</creatorcontrib><creatorcontrib>Castoldi, G</creatorcontrib><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lanza, F</au><au>Campioni, D</au><au>Punturieri, M</au><au>Moretti, S</au><au>Dabusti, M</au><au>Spanedda, R</au><au>Castoldi, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation: Endothelial Colonies</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><date>2003-12-01</date><risdate>2003</risdate><volume>32</volume><issue>12</issue><spage>1165</spage><epage>1173</epage><pages>1165-1173</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>The distribution and functional characteristics of
in vitro
bone marrow (BM) endothelial colonies (CFU-En) were studied in 70 non-Hodgkin's lymphoma (NHL) patients in different phases of the disease to explore the association between CFU-En growth and angiogenesis, and between the number of CFU-En and the presence of hematopoietic and mesenchymal progenitor cells. The mean number of CFU-En/10
6
BM mononuclear cells seen in remission patients was significantly higher than that seen in newly diagnosed patients (
P
=0.04), and in normal subjects (
P
=0.008). Patients with low-grade NHL in remission displayed a higher CFU-En value compared with high-grade NHL (
P
=0.04). In the autograft group (40 patients), a significant reduction of CFU-En number was detected in the first 4–6 months after transplantation. In remission patients, the CFU-En number positively correlated with the incidence of BM colony-forming unit granulocyte–macrophage (CFU-GM) (
P
=0.013) and CFU-multilineage (CFU-GEMM) hematopoietic colonies (
P
=0.044). These
in vitro
data show that CFU-En numbers increase following standard-dose chemotherapy, thus providing a rationale for further investigating the effects of different cytostatic drugs on BM endothelial cells growth and function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/sj.bmt.1704279</doi></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2003-12, Vol.32 (12), p.1165-1173 |
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| source | Nature; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cell Biology Hematology Internal Medicine Medicine Medicine & Public Health original-article Public Health Stem Cells |
| title | In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation: Endothelial Colonies |
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