The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

Neurofibromatosis type 2 (NF2) protein, also known as merlin or schwannomin, is a tumor suppressor, and NF2 is mutated in most schwannomas and meningiomas. Although these tumors are dependent on NF2, some lack detectable NF2 mutations, which indicates that alternative mechanisms exist for inactivati...

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Veröffentlicht in:	Nature medicine 1998-08, Vol.4 (8), p.915-922
Hauptverfasser:	Kimura, Yoriyoshi, Koga, Hisashi, Araki, Norie, Mugita, Norifumi, Fujita, Naoyuki, Takeshima, Hideo, Nishi, Tohru, Yamashima, Tetsumori, Saido, Takaomi C., Yamasaki, Toshiki, Moritake, Kouzo, Saya, Hideyuki, Nakao, Mitsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cancer Research Infectious Diseases Metabolic Diseases Molecular Medicine Neurosciences
Online-Zugang:	Volltext
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