A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer: Clinical Oncology/Epidemiology
Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of t...
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| Veröffentlicht in: | British journal of cancer 1989-07, Vol.60 (1), p.126-131 |
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| container_end_page | 131 |
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| container_issue | 1 |
| container_start_page | 126 |
| container_title | British journal of cancer |
| container_volume | 60 |
| creator | Powles, TJ Hardy, JR Ashley, SE Farrington, GM Cosgrove, D Davey, JB Dowsett, M McKinna, JA Nash, AG Sinnett, HD Tillyer, CR Treleaven, JG |
| description | Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started. |
| doi_str_mv | 10.1038/bjc.1989.235 |
| format | Article |
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We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/bjc.1989.235</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 1989-07, Vol.60 (1), p.126-131 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_springer_journals_10_1038_bjc_1989_235 |
| source | Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Research clinical-oncology-epidemiology Drug Resistance Epidemiology Molecular Medicine Oncology |
| title | A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer: Clinical Oncology/Epidemiology |
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