Helper T Cell Plasticity: Impact of Extrinsic and Intrinsic Signals on Transcriptomes and Epigenomes
CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review,...
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| Veröffentlicht in: | Current topics in microbiology and immunology 2014-01, Vol.381, p.279-326 |
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| container_title | Current topics in microbiology and immunology |
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| creator | Bonelli, Michael Shih, Han-Yu Hirahara, Kiyoshi Singelton, Kentner Laurence, Arian Poholek, Amanda Hand, Tim Mikami, Yohei Vahedi, Golnaz Kanno, Yuka O’Shea, John J. |
| description | CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales. |
| doi_str_mv | 10.1007/82_2014_371 |
| format | Article |
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Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. 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We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Enhancer Landscape</subject><subject>Epigenesis, Genetic</subject><subject>Humans</subject><subject>Immunology</subject><subject>lncRNAs</subject><subject>Signal Transducer And Activator Of Transcription (STAT)</subject><subject>Signal Transduction</subject><subject>T-Lymphocytes, Helper-Inducer - cytology</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>Topologically Associating Domains (TADs)</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptome</subject><subject>Treg Cells</subject><issn>0070-217X</issn><issn>2196-9965</issn><isbn>331907394X</isbn><isbn>9783319073941</isbn><isbn>3319073958</isbn><isbn>9783319073958</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1v1DAQxQ0F2qX0xB35CIfA2E78wQGpWi10pUogsUi9WV5nsjUkThpnEf3v8dLtBz2NRvN7741mCHnN4D0DUB80txxYaYViT8hLIZgBJUyln5IZZ0YWxsjq4H5QXjwjs6yDgjN18YLMtAHDGFP6iJyk9BMAmKiEVOKQHPFSCyZKOSP1GbYDjnRF59i29Fvr0hR8mK4_0mU3OD_RvqGLP9MYYgqeuljTZbztvodNdG2ifaSr0cXkxzBMfYfpH7cYwgbjrn1FnjeZw5N9PSY_Pi9W87Pi_OuX5fz0vPBCq6loUFbKr5EJjsyh0N6DabAGAcKAUFrWUhtXK2Seu6apBC85aI2-lr5sSnFMPt34Dtt1h7XHvKlr7TCGzo3XtnfB_j-J4dJu-t822-QImQ3e7g3G_mqLabJdSD4fxkXst8mySgIYzTlk9M3DrLuQ29Nm4N0NkPIobnC0677_lT3A7v5rH_w3s-WjXNzB-zX9pRsmHLPUSKk0yzpjuebiL7xbojM</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Bonelli, Michael</creator><creator>Shih, Han-Yu</creator><creator>Hirahara, Kiyoshi</creator><creator>Singelton, Kentner</creator><creator>Laurence, Arian</creator><creator>Poholek, Amanda</creator><creator>Hand, Tim</creator><creator>Mikami, Yohei</creator><creator>Vahedi, Golnaz</creator><creator>Kanno, Yuka</creator><creator>O’Shea, John J.</creator><general>Springer International Publishing AG</general><general>Springer International Publishing</general><scope>FFUUA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Helper T Cell Plasticity: Impact of Extrinsic and Intrinsic Signals on Transcriptomes and Epigenomes</title><author>Bonelli, Michael ; 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| subjects | Animals Cell Differentiation Enhancer Landscape Epigenesis, Genetic Humans Immunology lncRNAs Signal Transducer And Activator Of Transcription (STAT) Signal Transduction T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - metabolism Topologically Associating Domains (TADs) Transcription Factors - genetics Transcription Factors - metabolism Transcriptome Treg Cells |
| title | Helper T Cell Plasticity: Impact of Extrinsic and Intrinsic Signals on Transcriptomes and Epigenomes |
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