Microbicide Dosage Forms
Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent op...
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| creator | Rohan, L. C. Devlin, B. Yang, H. |
| description | Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become important to have longer acting products to minimize the burden of user compliance and thus vaginal rings have been developed providing sustained delivery of antiretroviral drugs. This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers. |
| doi_str_mv | 10.1007/82_2013_357 |
| format | Book Chapter |
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This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers.</description><subject>Anti-HIV Agents - pharmacology</subject><subject>Cellulose Acetate Phthalate</subject><subject>Clinical Trials as Topic</subject><subject>Dosage Form</subject><subject>Dosage Forms</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Delivery Systems - methods</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - physiology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Medical microbiology & virology</subject><subject>Microbicide Candidate</subject><subject>Pharmaceutical technology</subject><subject>Vaginal Ring</subject><subject>Vaginal Tablet</subject><issn>0070-217X</issn><issn>2196-9965</issn><isbn>9783662445952</isbn><isbn>3662445956</isbn><isbn>3662445964</isbn><isbn>9783662445969</isbn><fulltext>true</fulltext><rsrctype>book_chapter</rsrctype><creationdate>2014</creationdate><recordtype>book_chapter</recordtype><sourceid>EIF</sourceid><recordid>eNpdkL1PwzAQxc13Q-nEwoQ6whA4f-Rsj6hQQCpiAYnNchynBJKmxOnAf4-rUgkhnXTD-713ukfIKYUrCiCvFTMMKDc8kzvkmCMyITKNYpckjGpMtcZsj4y0VFstY_skiVZIGZVvhyRRGhQoKmBARiF8AMS8jKPAIzJggjGQGU3I2VPlujavXFX48W0b7NyPp23XhBNyUNo6-NHvHpLX6d3L5CGdPd8_Tm5mqeMc-lTmWJTCl9RaW_qcInLnURXgdCmoUCpHyxgKCqWLY0FnTigvpabCoZN8SC42ucuu_Vr50JumCs7XtV34dhUMzZACRyZFRM9_0VXe-MIsu6qx3bfZfhOByw0QorSY-87kbfsZM8CsWzV_Wo0s-3fXr2HnF31na_dul73volUjSgXRF138BzIUbvE</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Rohan, L. C.</creator><creator>Devlin, B.</creator><creator>Yang, H.</creator><general>Springer Berlin / Heidelberg</general><general>Springer Berlin Heidelberg</general><scope>FFUUA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Microbicide Dosage Forms</title><author>Rohan, L. 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C.</au><au>Devlin, B.</au><au>Yang, H.</au><au>Nuttall, Jeremy</au><au>Nuttall, Jeremy</au><format>book</format><genre>bookitem</genre><ristype>CHAP</ristype><atitle>Microbicide Dosage Forms</atitle><btitle>Current topics in microbiology and immunology</btitle><addtitle>Curr Top Microbiol Immunol</addtitle><seriestitle>Current Topics in Microbiology and Immunology</seriestitle><date>2014-01-01</date><risdate>2014</risdate><volume>383</volume><spage>27</spage><epage>54</epage><pages>27-54</pages><issn>0070-217X</issn><eissn>2196-9965</eissn><isbn>9783662445952</isbn><isbn>3662445956</isbn><eisbn>3662445964</eisbn><eisbn>9783662445969</eisbn><abstract>Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become important to have longer acting products to minimize the burden of user compliance and thus vaginal rings have been developed providing sustained delivery of antiretroviral drugs. This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers.</abstract><cop>Germany</cop><pub>Springer Berlin / Heidelberg</pub><pmid>24220751</pmid><doi>10.1007/82_2013_357</doi><oclcid>890808140</oclcid><tpages>28</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0070-217X |
| ispartof | Current topics in microbiology and immunology, 2014, Vol.383, p.27-54 |
| issn | 0070-217X 2196-9965 |
| language | eng |
| recordid | cdi_springer_books_10_1007_82_2013_357 |
| source | MEDLINE; Springer Books |
| subjects | Anti-HIV Agents - pharmacology Cellulose Acetate Phthalate Clinical Trials as Topic Dosage Form Dosage Forms Drug Delivery Systems - instrumentation Drug Delivery Systems - methods HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - physiology Humans Immunology Medical microbiology & virology Microbicide Candidate Pharmaceutical technology Vaginal Ring Vaginal Tablet |
| title | Microbicide Dosage Forms |
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