Dopaminergic Neuron-Specific Autophagy-Deficient Mice

None of the current genetic Parkinson’s disease (PD) models in mouse recapitulates all features of PD. Additionally, only a few of these models develop mild dopamine (DA) neurodegeneration. And the most parsimonious explanation for the lack of DA neurodegeneration in genetic PD models is a compensat...

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Veröffentlicht in:	Methods in molecular biology (Clifton, N.J.) N.J.), 2018, Vol.1759, p.173-175
Hauptverfasser:	Sato, Shigeto, Hattori, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atg7 Autophagy Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Behavior, Animal Biomarkers Disease Models, Animal Dopaminergic neuron Dopaminergic Neurons - metabolism Lewy body Mice Mitochondria - genetics Mitochondria - metabolism Mouse model Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson’s disease Phenotype
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