Selection of Antibodies Interfering with Cell Surface Receptor Signaling Using Embryonic Stem Cell Differentiation

Antibodies able to bind and modify the function of cell surface signaling components in vivo are increasingly being used as therapeutic drugs. The identification of such “functional” antibodies from within large antibody pools is, therefore, the subject of intense research. Here we describe a novel...

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Veröffentlicht in:	Embryonic Stem Cell Protocols 2016-01, Vol.1341, p.111-132
Hauptverfasser:	Melidoni, Anna N., Dyson, Michael R., McCafferty, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - genetics Antibodies - metabolism Cell Culture Techniques - methods Cell Differentiation Cell Line Cell surface receptor signaling Cells, Cultured Cloning, Molecular - methods Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism ES cell differentiation FGF4 FGFR1 Functional antibody Humans Mice Peptide Library Phage display Phenotypic selection Protein knockdown Receptors, Cell Surface - metabolism Signal Transduction Transfection - methods
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