Hyperforin: To Be or Not to Be an Activator of TRPC(6)

Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John’s wort, is the pharmacophore of St. John’s wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regard...

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Veröffentlicht in:	Reviews of Physiology, Biochemistry and Pharmacology Vol. 169 Biochemistry and Pharmacology Vol. 169, 2015-01, Vol.169, p.1-24
Hauptverfasser:	Friedland, Kristina, Harteneck, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Botany & plant sciences Calcium homeostasis Cytochrome P-450 Enzyme Inducers - pharmacology Depression Drug Stability Humans Hyperforin Ion channel Pharmacology Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - pharmacology Physiology Protonophore St. John's wort Terpenes - chemistry Terpenes - pharmacology TRP channel TRPC Cation Channels - drug effects TRPC Cation Channels - physiology TRPC6 Cation Channel
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