Application of infrared light for
A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve...
Gespeichert in:
| Veröffentlicht in: | Journal of Biomedical Optics 2005-11, Vol.10 (6), p.064003-0640012 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 0640012 |
|---|---|
| container_issue | 6 |
| container_start_page | 064003 |
| container_title | Journal of Biomedical Optics |
| container_volume | 10 |
| creator | Wells, Jonathon Kao, Chris Jansen, E. Duco Konrad, Peter Mahadevan-Jansen, Anita |
| description | A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation and damage thresholds were determined as a function of wavelength using a tunable free electron laser source
and a solid state holmium:YAG laser
. Threshold radiant exposure required for stimulation varies with wavelength from
to
. Histological analysis indicates no discernable thermal damage with suprathreshold stimulation. The largest damage/stimulation threshold ratios
were at wavelengths corresponding to valleys in the IR spectrum of soft tissue absorption (4 and
). Furthermore, optical stimulation can be used to generate a spatially selective response in small fascicles of the sciatic nerve that has significant advantages (e.g., noncontact, spatial resolution, lack of stimulation artifact) over conventional electrical methods in diagnostic and therapeutic procedures in neuroscience, neurology, and neurosurgery. |
| doi_str_mv | 10.1117/1.2121772 |
| format | Article |
| fullrecord | <record><control><sourceid>spie</sourceid><recordid>TN_cdi_spie_primary_JBOPFO000010000006064003000001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JBOPFO000010000006064003000001</sourcerecordid><originalsourceid>FETCH-spie_primary_JBOPFO0000100000060640030000013</originalsourceid><addsrcrecordid>eNqdjL0OgjAURm-MJuLP4BvUBwDvbbXUUY3EuODgThqlWoPQtCy-vYT4BJ7lO8t3ABaECRGlK0o4cUpTPoCINhJjzhUNO0clYiGlGsMkhBciKrmVESx3zlX2plvb1KwxzNbGa1_eWWUfz5aZxs9gZHQVyvlvp8Cz4_VwioOzZeG8fWv_Kc77_JLlXRYJeyTKNaLoncRfpy_hfjZQ</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Application of infrared light for</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Wells, Jonathon ; Kao, Chris ; Jansen, E. Duco ; Konrad, Peter ; Mahadevan-Jansen, Anita</creator><creatorcontrib>Wells, Jonathon ; Kao, Chris ; Jansen, E. Duco ; Konrad, Peter ; Mahadevan-Jansen, Anita</creatorcontrib><description>A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation and damage thresholds were determined as a function of wavelength using a tunable free electron laser source
and a solid state holmium:YAG laser
. Threshold radiant exposure required for stimulation varies with wavelength from
to
. Histological analysis indicates no discernable thermal damage with suprathreshold stimulation. The largest damage/stimulation threshold ratios
were at wavelengths corresponding to valleys in the IR spectrum of soft tissue absorption (4 and
). Furthermore, optical stimulation can be used to generate a spatially selective response in small fascicles of the sciatic nerve that has significant advantages (e.g., noncontact, spatial resolution, lack of stimulation artifact) over conventional electrical methods in diagnostic and therapeutic procedures in neuroscience, neurology, and neurosurgery.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.2121772</identifier><identifier>CODEN: JBOPFO</identifier><language>eng</language><subject>lasers ; neural excitation techniques ; optical stimulation ; peripheral nerve stimulation</subject><ispartof>Journal of Biomedical Optics, 2005-11, Vol.10 (6), p.064003-0640012</ispartof><rights>2005 Society of Photo-Optical Instrumentation Engineers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Wells, Jonathon</creatorcontrib><creatorcontrib>Kao, Chris</creatorcontrib><creatorcontrib>Jansen, E. Duco</creatorcontrib><creatorcontrib>Konrad, Peter</creatorcontrib><creatorcontrib>Mahadevan-Jansen, Anita</creatorcontrib><title>Application of infrared light for</title><title>Journal of Biomedical Optics</title><description>A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation and damage thresholds were determined as a function of wavelength using a tunable free electron laser source
and a solid state holmium:YAG laser
. Threshold radiant exposure required for stimulation varies with wavelength from
to
. Histological analysis indicates no discernable thermal damage with suprathreshold stimulation. The largest damage/stimulation threshold ratios
were at wavelengths corresponding to valleys in the IR spectrum of soft tissue absorption (4 and
). Furthermore, optical stimulation can be used to generate a spatially selective response in small fascicles of the sciatic nerve that has significant advantages (e.g., noncontact, spatial resolution, lack of stimulation artifact) over conventional electrical methods in diagnostic and therapeutic procedures in neuroscience, neurology, and neurosurgery.</description><subject>lasers</subject><subject>neural excitation techniques</subject><subject>optical stimulation</subject><subject>peripheral nerve stimulation</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqdjL0OgjAURm-MJuLP4BvUBwDvbbXUUY3EuODgThqlWoPQtCy-vYT4BJ7lO8t3ABaECRGlK0o4cUpTPoCINhJjzhUNO0clYiGlGsMkhBciKrmVESx3zlX2plvb1KwxzNbGa1_eWWUfz5aZxs9gZHQVyvlvp8Cz4_VwioOzZeG8fWv_Kc77_JLlXRYJeyTKNaLoncRfpy_hfjZQ</recordid><startdate>20051103</startdate><enddate>20051103</enddate><creator>Wells, Jonathon</creator><creator>Kao, Chris</creator><creator>Jansen, E. Duco</creator><creator>Konrad, Peter</creator><creator>Mahadevan-Jansen, Anita</creator><scope/></search><sort><creationdate>20051103</creationdate><title>Application of infrared light for</title><author>Wells, Jonathon ; Kao, Chris ; Jansen, E. Duco ; Konrad, Peter ; Mahadevan-Jansen, Anita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-spie_primary_JBOPFO0000100000060640030000013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>lasers</topic><topic>neural excitation techniques</topic><topic>optical stimulation</topic><topic>peripheral nerve stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wells, Jonathon</creatorcontrib><creatorcontrib>Kao, Chris</creatorcontrib><creatorcontrib>Jansen, E. Duco</creatorcontrib><creatorcontrib>Konrad, Peter</creatorcontrib><creatorcontrib>Mahadevan-Jansen, Anita</creatorcontrib><jtitle>Journal of Biomedical Optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wells, Jonathon</au><au>Kao, Chris</au><au>Jansen, E. Duco</au><au>Konrad, Peter</au><au>Mahadevan-Jansen, Anita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of infrared light for</atitle><jtitle>Journal of Biomedical Optics</jtitle><date>2005-11-03</date><risdate>2005</risdate><volume>10</volume><issue>6</issue><spage>064003</spage><epage>0640012</epage><pages>064003-0640012</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><coden>JBOPFO</coden><abstract>A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-energy infrared laser light is presented. Optical stimulation elicits compound nerve and muscle potentials similar to responses obtained with conventional electrical neural stimulation in a rat sciatic nerve model. Stimulation and damage thresholds were determined as a function of wavelength using a tunable free electron laser source
and a solid state holmium:YAG laser
. Threshold radiant exposure required for stimulation varies with wavelength from
to
. Histological analysis indicates no discernable thermal damage with suprathreshold stimulation. The largest damage/stimulation threshold ratios
were at wavelengths corresponding to valleys in the IR spectrum of soft tissue absorption (4 and
). Furthermore, optical stimulation can be used to generate a spatially selective response in small fascicles of the sciatic nerve that has significant advantages (e.g., noncontact, spatial resolution, lack of stimulation artifact) over conventional electrical methods in diagnostic and therapeutic procedures in neuroscience, neurology, and neurosurgery.</abstract><doi>10.1117/1.2121772</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-3668 |
| ispartof | Journal of Biomedical Optics, 2005-11, Vol.10 (6), p.064003-0640012 |
| issn | 1083-3668 1560-2281 |
| language | eng |
| recordid | cdi_spie_primary_JBOPFO000010000006064003000001 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | lasers neural excitation techniques optical stimulation peripheral nerve stimulation |
| title | Application of infrared light for |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T03%3A31%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-spie&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Application%20of%20infrared%20light%20for&rft.jtitle=Journal%20of%20Biomedical%20Optics&rft.au=Wells,%20Jonathon&rft.date=2005-11-03&rft.volume=10&rft.issue=6&rft.spage=064003&rft.epage=0640012&rft.pages=064003-0640012&rft.issn=1083-3668&rft.eissn=1560-2281&rft.coden=JBOPFO&rft_id=info:doi/10.1117/1.2121772&rft_dat=%3Cspie%3EJBOPFO000010000006064003000001%3C/spie%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |