Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound
Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically osc...
Gespeichert in:
Veröffentlicht in: | The Journal of the Acoustical Society of America 2017-11, Vol.142 (5), p.3135-3146 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 3146 |
---|---|
container_issue | 5 |
container_start_page | 3135 |
container_title | The Journal of the Acoustical Society of America |
container_volume | 142 |
creator | Lazarus, Carole Pouliopoulos, Antonios N. Tinguely, Marc Garbin, Valeria Choi, James J. |
description | Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50–100 kPa and a pulse length of 20 ms. Microbubbles exposed to low-pressure therapeutic ultrasound were observed to cluster at clustering rates of 0.01–0.02 microbubbles per duration (in ms) per initial average inter-bubble distance (in μm), resulting in 1 to 3 clustered microbubbles per initial average inter-bubble distance (in μm). Higher pressures caused faster clustering rates and a larger number of clustered microbubbles. Experimental data revealed clustering time scales, cluster localizations, and cluster sizes that were in reasonable agreement with simulations using a time-averaged model at low pressures. This study demonstrates that clustering of microbubbles occurs within a few milliseconds and is likely to influence the distribution of stimuli produced in therapeutic applications. |
doi_str_mv | 10.1121/1.5010170 |
format | Article |
fullrecord | <record><control><sourceid>proquest_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1121_1_5010170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1971710367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-63f226045fe538e99879d948d9f469e896edb5c5b7e57aa4ae0a1fd1494323f43</originalsourceid><addsrcrecordid>eNp90EFLxDAQBeAgiruuHvwD0qMKXTNN0jZHWdQVVrzouaTNRCptU5NGXX-9lV31pKfHwMeDeYQcA50DJHABc0GBQkZ3yBREQuNcJHyXTCmlEHOZphNy4P3zeIqcyX0ySSRIwTM2JatFE_yAru6eIr3uVFtXPrImGtPZMpRlgz7C99561NFgo8a-xb1D74PDCOK75UcUmsEpb0OnD8meUY3Ho23OyOP11cNiGa_ub24Xl6u44gkMccpMkqSUC4OC5Shlnkktea6l4anEXKaoS1GJMkORKcUVUgVGA5ecJcxwNiOnm97e2ZeAfija2lfYNKpDG3wBMoMMKEuzkZ5t6PiO9w5N0bu6VW5dAC2-xiug2I432pNtbShb1D_ye60RnG-Ar-pBDbXt_m37E79a9wuLXhv2Cf20hN4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1971710367</pqid></control><display><type>article</type><title>Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound</title><source>Scitation (American Institute of Physics)</source><source>Alma/SFX Local Collection</source><source>AIP Acoustical Society of America</source><creator>Lazarus, Carole ; Pouliopoulos, Antonios N. ; Tinguely, Marc ; Garbin, Valeria ; Choi, James J.</creator><creatorcontrib>Lazarus, Carole ; Pouliopoulos, Antonios N. ; Tinguely, Marc ; Garbin, Valeria ; Choi, James J.</creatorcontrib><description>Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50–100 kPa and a pulse length of 20 ms. Microbubbles exposed to low-pressure therapeutic ultrasound were observed to cluster at clustering rates of 0.01–0.02 microbubbles per duration (in ms) per initial average inter-bubble distance (in μm), resulting in 1 to 3 clustered microbubbles per initial average inter-bubble distance (in μm). Higher pressures caused faster clustering rates and a larger number of clustered microbubbles. Experimental data revealed clustering time scales, cluster localizations, and cluster sizes that were in reasonable agreement with simulations using a time-averaged model at low pressures. This study demonstrates that clustering of microbubbles occurs within a few milliseconds and is likely to influence the distribution of stimuli produced in therapeutic applications.</description><identifier>ISSN: 0001-4966</identifier><identifier>EISSN: 1520-8524</identifier><identifier>DOI: 10.1121/1.5010170</identifier><identifier>PMID: 29195473</identifier><identifier>CODEN: JASMAN</identifier><language>eng</language><publisher>United States</publisher><ispartof>The Journal of the Acoustical Society of America, 2017-11, Vol.142 (5), p.3135-3146</ispartof><rights>Acoustical Society of America</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-63f226045fe538e99879d948d9f469e896edb5c5b7e57aa4ae0a1fd1494323f43</citedby><cites>FETCH-LOGICAL-c421t-63f226045fe538e99879d948d9f469e896edb5c5b7e57aa4ae0a1fd1494323f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/jasa/article-lookup/doi/10.1121/1.5010170$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>207,208,314,776,780,790,1559,4498,27901,27902,76127</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29195473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazarus, Carole</creatorcontrib><creatorcontrib>Pouliopoulos, Antonios N.</creatorcontrib><creatorcontrib>Tinguely, Marc</creatorcontrib><creatorcontrib>Garbin, Valeria</creatorcontrib><creatorcontrib>Choi, James J.</creatorcontrib><title>Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound</title><title>The Journal of the Acoustical Society of America</title><addtitle>J Acoust Soc Am</addtitle><description>Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50–100 kPa and a pulse length of 20 ms. Microbubbles exposed to low-pressure therapeutic ultrasound were observed to cluster at clustering rates of 0.01–0.02 microbubbles per duration (in ms) per initial average inter-bubble distance (in μm), resulting in 1 to 3 clustered microbubbles per initial average inter-bubble distance (in μm). Higher pressures caused faster clustering rates and a larger number of clustered microbubbles. Experimental data revealed clustering time scales, cluster localizations, and cluster sizes that were in reasonable agreement with simulations using a time-averaged model at low pressures. This study demonstrates that clustering of microbubbles occurs within a few milliseconds and is likely to influence the distribution of stimuli produced in therapeutic applications.</description><issn>0001-4966</issn><issn>1520-8524</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp90EFLxDAQBeAgiruuHvwD0qMKXTNN0jZHWdQVVrzouaTNRCptU5NGXX-9lV31pKfHwMeDeYQcA50DJHABc0GBQkZ3yBREQuNcJHyXTCmlEHOZphNy4P3zeIqcyX0ySSRIwTM2JatFE_yAru6eIr3uVFtXPrImGtPZMpRlgz7C99561NFgo8a-xb1D74PDCOK75UcUmsEpb0OnD8meUY3Ho23OyOP11cNiGa_ub24Xl6u44gkMccpMkqSUC4OC5Shlnkktea6l4anEXKaoS1GJMkORKcUVUgVGA5ecJcxwNiOnm97e2ZeAfija2lfYNKpDG3wBMoMMKEuzkZ5t6PiO9w5N0bu6VW5dAC2-xiug2I432pNtbShb1D_ye60RnG-Ar-pBDbXt_m37E79a9wuLXhv2Cf20hN4</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Lazarus, Carole</creator><creator>Pouliopoulos, Antonios N.</creator><creator>Tinguely, Marc</creator><creator>Garbin, Valeria</creator><creator>Choi, James J.</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201711</creationdate><title>Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound</title><author>Lazarus, Carole ; Pouliopoulos, Antonios N. ; Tinguely, Marc ; Garbin, Valeria ; Choi, James J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-63f226045fe538e99879d948d9f469e896edb5c5b7e57aa4ae0a1fd1494323f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazarus, Carole</creatorcontrib><creatorcontrib>Pouliopoulos, Antonios N.</creatorcontrib><creatorcontrib>Tinguely, Marc</creatorcontrib><creatorcontrib>Garbin, Valeria</creatorcontrib><creatorcontrib>Choi, James J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of the Acoustical Society of America</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazarus, Carole</au><au>Pouliopoulos, Antonios N.</au><au>Tinguely, Marc</au><au>Garbin, Valeria</au><au>Choi, James J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound</atitle><jtitle>The Journal of the Acoustical Society of America</jtitle><addtitle>J Acoust Soc Am</addtitle><date>2017-11</date><risdate>2017</risdate><volume>142</volume><issue>5</issue><spage>3135</spage><epage>3146</epage><pages>3135-3146</pages><issn>0001-4966</issn><eissn>1520-8524</eissn><coden>JASMAN</coden><abstract>Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50–100 kPa and a pulse length of 20 ms. Microbubbles exposed to low-pressure therapeutic ultrasound were observed to cluster at clustering rates of 0.01–0.02 microbubbles per duration (in ms) per initial average inter-bubble distance (in μm), resulting in 1 to 3 clustered microbubbles per initial average inter-bubble distance (in μm). Higher pressures caused faster clustering rates and a larger number of clustered microbubbles. Experimental data revealed clustering time scales, cluster localizations, and cluster sizes that were in reasonable agreement with simulations using a time-averaged model at low pressures. This study demonstrates that clustering of microbubbles occurs within a few milliseconds and is likely to influence the distribution of stimuli produced in therapeutic applications.</abstract><cop>United States</cop><pmid>29195473</pmid><doi>10.1121/1.5010170</doi><tpages>12</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0001-4966 |
ispartof | The Journal of the Acoustical Society of America, 2017-11, Vol.142 (5), p.3135-3146 |
issn | 0001-4966 1520-8524 |
language | eng |
recordid | cdi_scitation_primary_10_1121_1_5010170 |
source | Scitation (American Institute of Physics); Alma/SFX Local Collection; AIP Acoustical Society of America |
title | Clustering dynamics of microbubbles exposed to low-pressure 1-MHz ultrasound |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A44%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_scita&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clustering%20dynamics%20of%20microbubbles%20exposed%20to%20low-pressure%201-MHz%20ultrasound&rft.jtitle=The%20Journal%20of%20the%20Acoustical%20Society%20of%20America&rft.au=Lazarus,%20Carole&rft.date=2017-11&rft.volume=142&rft.issue=5&rft.spage=3135&rft.epage=3146&rft.pages=3135-3146&rft.issn=0001-4966&rft.eissn=1520-8524&rft.coden=JASMAN&rft_id=info:doi/10.1121/1.5010170&rft_dat=%3Cproquest_scita%3E1971710367%3C/proquest_scita%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1971710367&rft_id=info:pmid/29195473&rfr_iscdi=true |