SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?
Purpose: Evaluate the differences in dose distributions between the proton analytic semi-empirical dose calculation algorithm used in the clinic and Monte Carlo calculations for a sample of 50 head-and-neck (H&N) patients and estimate the potential clinical significance of the differences. Metho...
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| Veröffentlicht in: | Medical physics (Lancaster) 2016-06, Vol.43 (6), p.3496-3496 |
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| creator | Yepes, P Titt, U Mirkovic, D Liu, A Frank, S Mohan, R |
| description | Purpose:
Evaluate the differences in dose distributions between the proton analytic semi-empirical dose calculation algorithm used in the clinic and Monte Carlo calculations for a sample of 50 head-and-neck (H&N) patients and estimate the potential clinical significance of the differences.
Methods:
A cohort of 50 H&N patients, treated at the University of Texas Cancer Center with Intensity Modulated Proton Therapy (IMPT), were selected for evaluation of clinical significance of approximations in computed dose distributions. H&N site was selected because of the highly inhomogeneous nature of the anatomy. The Fast Dose Calculator (FDC), a fast track-repeating accelerated Monte Carlo algorithm for proton therapy, was utilized for the calculation of dose distributions delivered during treatment plans. Because of its short processing time, FDC allows for the processing of large cohorts of patients. FDC has been validated versus GEANT4, a full Monte Carlo system and measurements in water and for inhomogeneous phantoms. A gamma-index analysis, DVHs, EUDs, and TCP and NTCPs computed using published models were utilized to evaluate the differences between the Treatment Plan System (TPS) and FDC.
Results:
The Monte Carlo results systematically predict lower dose delivered in the target. The observed differences can be as large as 8 Gy, and should have a clinical impact. Gamma analysis also showed significant differences between both approaches, especially for the target volumes.
Conclusion:
Monte Carlo calculations with fast algorithms is practical and should be considered for the clinic, at least as a treatment plan verification tool. |
| doi_str_mv | 10.1118/1.4956284 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1118_1_4956284</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MP6284</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1354-e726cd9b46ab377e36393783216a7a4a81c1dceeceadae59e83a06df9f91eaf43</originalsourceid><addsrcrecordid>eNp90Utv1DAQB_AIgcRSOPANRuIEkls7dh7mgqLQl9RCpd2eI9eZ7BocO7KNaD4g34vs4wqn0Yx-mr80k2XvGT1njNUX7FzIosxr8SJb5aLiRORUvsxWlEpBckGL19mbGH9QSkte0FX2Z_1IrsiGMFF_hiYgpB1CM03BP5tRJeNdBOOgccrOyWhY42jI5TiZYLSy8NVHhFZZ_cseMDR264NJuzHC4APcuoQumjTDve_3Bnt4CD4tcrPDoKb5wFo_Thaf4QYTBr9FhyYZjOCHZaR6UK6Hb6h_QmuN2wfbGdZm68ywNC59eZu9GpSN-O5Uz7LHq8tNe0Puvl_fts0d0YwXgmCVl7qXT6JUT7yqkJdc8qrmOStVpYSqmWa9RtRLpsJCYs0VLftBDpKhGgQ_yz4c9_qYTBe1Sah32juHOnV5Xoqc13JRH49KBx9jwKGbwnLMMHeMdvsvdaw7fWmx5Gh_G4vzv2F3_3Dyn45-H344-X-W_wWqY6Jg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?</title><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Yepes, P ; Titt, U ; Mirkovic, D ; Liu, A ; Frank, S ; Mohan, R</creator><creatorcontrib>Yepes, P ; Titt, U ; Mirkovic, D ; Liu, A ; Frank, S ; Mohan, R</creatorcontrib><description>Purpose:
Evaluate the differences in dose distributions between the proton analytic semi-empirical dose calculation algorithm used in the clinic and Monte Carlo calculations for a sample of 50 head-and-neck (H&N) patients and estimate the potential clinical significance of the differences.
Methods:
A cohort of 50 H&N patients, treated at the University of Texas Cancer Center with Intensity Modulated Proton Therapy (IMPT), were selected for evaluation of clinical significance of approximations in computed dose distributions. H&N site was selected because of the highly inhomogeneous nature of the anatomy. The Fast Dose Calculator (FDC), a fast track-repeating accelerated Monte Carlo algorithm for proton therapy, was utilized for the calculation of dose distributions delivered during treatment plans. Because of its short processing time, FDC allows for the processing of large cohorts of patients. FDC has been validated versus GEANT4, a full Monte Carlo system and measurements in water and for inhomogeneous phantoms. A gamma-index analysis, DVHs, EUDs, and TCP and NTCPs computed using published models were utilized to evaluate the differences between the Treatment Plan System (TPS) and FDC.
Results:
The Monte Carlo results systematically predict lower dose delivered in the target. The observed differences can be as large as 8 Gy, and should have a clinical impact. Gamma analysis also showed significant differences between both approaches, especially for the target volumes.
Conclusion:
Monte Carlo calculations with fast algorithms is practical and should be considered for the clinic, at least as a treatment plan verification tool.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4956284</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>60 APPLIED LIFE SCIENCES ; ALGORITHMS ; Anatomy ; CALCULATORS ; Cancer ; Drug delivery ; EDUCATIONAL FACILITIES ; EVALUATION ; Monte Carlo algorithms ; MONTE CARLO METHOD ; PATIENTS ; PROTON BEAMS ; Proton therapy ; Protons ; RADIATION DOSE DISTRIBUTIONS ; RADIATION PROTECTION AND DOSIMETRY ; RADIOTHERAPY</subject><ispartof>Medical physics (Lancaster), 2016-06, Vol.43 (6), p.3496-3496</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2016 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4956284$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27928,27929,45579</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22642389$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Yepes, P</creatorcontrib><creatorcontrib>Titt, U</creatorcontrib><creatorcontrib>Mirkovic, D</creatorcontrib><creatorcontrib>Liu, A</creatorcontrib><creatorcontrib>Frank, S</creatorcontrib><creatorcontrib>Mohan, R</creatorcontrib><title>SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?</title><title>Medical physics (Lancaster)</title><description>Purpose:
Evaluate the differences in dose distributions between the proton analytic semi-empirical dose calculation algorithm used in the clinic and Monte Carlo calculations for a sample of 50 head-and-neck (H&N) patients and estimate the potential clinical significance of the differences.
Methods:
A cohort of 50 H&N patients, treated at the University of Texas Cancer Center with Intensity Modulated Proton Therapy (IMPT), were selected for evaluation of clinical significance of approximations in computed dose distributions. H&N site was selected because of the highly inhomogeneous nature of the anatomy. The Fast Dose Calculator (FDC), a fast track-repeating accelerated Monte Carlo algorithm for proton therapy, was utilized for the calculation of dose distributions delivered during treatment plans. Because of its short processing time, FDC allows for the processing of large cohorts of patients. FDC has been validated versus GEANT4, a full Monte Carlo system and measurements in water and for inhomogeneous phantoms. A gamma-index analysis, DVHs, EUDs, and TCP and NTCPs computed using published models were utilized to evaluate the differences between the Treatment Plan System (TPS) and FDC.
Results:
The Monte Carlo results systematically predict lower dose delivered in the target. The observed differences can be as large as 8 Gy, and should have a clinical impact. Gamma analysis also showed significant differences between both approaches, especially for the target volumes.
Conclusion:
Monte Carlo calculations with fast algorithms is practical and should be considered for the clinic, at least as a treatment plan verification tool.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>ALGORITHMS</subject><subject>Anatomy</subject><subject>CALCULATORS</subject><subject>Cancer</subject><subject>Drug delivery</subject><subject>EDUCATIONAL FACILITIES</subject><subject>EVALUATION</subject><subject>Monte Carlo algorithms</subject><subject>MONTE CARLO METHOD</subject><subject>PATIENTS</subject><subject>PROTON BEAMS</subject><subject>Proton therapy</subject><subject>Protons</subject><subject>RADIATION DOSE DISTRIBUTIONS</subject><subject>RADIATION PROTECTION AND DOSIMETRY</subject><subject>RADIOTHERAPY</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp90Utv1DAQB_AIgcRSOPANRuIEkls7dh7mgqLQl9RCpd2eI9eZ7BocO7KNaD4g34vs4wqn0Yx-mr80k2XvGT1njNUX7FzIosxr8SJb5aLiRORUvsxWlEpBckGL19mbGH9QSkte0FX2Z_1IrsiGMFF_hiYgpB1CM03BP5tRJeNdBOOgccrOyWhY42jI5TiZYLSy8NVHhFZZ_cseMDR264NJuzHC4APcuoQumjTDve_3Bnt4CD4tcrPDoKb5wFo_Thaf4QYTBr9FhyYZjOCHZaR6UK6Hb6h_QmuN2wfbGdZm68ywNC59eZu9GpSN-O5Uz7LHq8tNe0Puvl_fts0d0YwXgmCVl7qXT6JUT7yqkJdc8qrmOStVpYSqmWa9RtRLpsJCYs0VLftBDpKhGgQ_yz4c9_qYTBe1Sah32juHOnV5Xoqc13JRH49KBx9jwKGbwnLMMHeMdvsvdaw7fWmx5Gh_G4vzv2F3_3Dyn45-H344-X-W_wWqY6Jg</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Yepes, P</creator><creator>Titt, U</creator><creator>Mirkovic, D</creator><creator>Liu, A</creator><creator>Frank, S</creator><creator>Mohan, R</creator><general>American Association of Physicists in Medicine</general><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>201606</creationdate><title>SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?</title><author>Yepes, P ; Titt, U ; Mirkovic, D ; Liu, A ; Frank, S ; Mohan, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1354-e726cd9b46ab377e36393783216a7a4a81c1dceeceadae59e83a06df9f91eaf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>ALGORITHMS</topic><topic>Anatomy</topic><topic>CALCULATORS</topic><topic>Cancer</topic><topic>Drug delivery</topic><topic>EDUCATIONAL FACILITIES</topic><topic>EVALUATION</topic><topic>Monte Carlo algorithms</topic><topic>MONTE CARLO METHOD</topic><topic>PATIENTS</topic><topic>PROTON BEAMS</topic><topic>Proton therapy</topic><topic>Protons</topic><topic>RADIATION DOSE DISTRIBUTIONS</topic><topic>RADIATION PROTECTION AND DOSIMETRY</topic><topic>RADIOTHERAPY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yepes, P</creatorcontrib><creatorcontrib>Titt, U</creatorcontrib><creatorcontrib>Mirkovic, D</creatorcontrib><creatorcontrib>Liu, A</creatorcontrib><creatorcontrib>Frank, S</creatorcontrib><creatorcontrib>Mohan, R</creatorcontrib><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yepes, P</au><au>Titt, U</au><au>Mirkovic, D</au><au>Liu, A</au><au>Frank, S</au><au>Mohan, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant?</atitle><jtitle>Medical physics (Lancaster)</jtitle><date>2016-06</date><risdate>2016</risdate><volume>43</volume><issue>6</issue><spage>3496</spage><epage>3496</epage><pages>3496-3496</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
Evaluate the differences in dose distributions between the proton analytic semi-empirical dose calculation algorithm used in the clinic and Monte Carlo calculations for a sample of 50 head-and-neck (H&N) patients and estimate the potential clinical significance of the differences.
Methods:
A cohort of 50 H&N patients, treated at the University of Texas Cancer Center with Intensity Modulated Proton Therapy (IMPT), were selected for evaluation of clinical significance of approximations in computed dose distributions. H&N site was selected because of the highly inhomogeneous nature of the anatomy. The Fast Dose Calculator (FDC), a fast track-repeating accelerated Monte Carlo algorithm for proton therapy, was utilized for the calculation of dose distributions delivered during treatment plans. Because of its short processing time, FDC allows for the processing of large cohorts of patients. FDC has been validated versus GEANT4, a full Monte Carlo system and measurements in water and for inhomogeneous phantoms. A gamma-index analysis, DVHs, EUDs, and TCP and NTCPs computed using published models were utilized to evaluate the differences between the Treatment Plan System (TPS) and FDC.
Results:
The Monte Carlo results systematically predict lower dose delivered in the target. The observed differences can be as large as 8 Gy, and should have a clinical impact. Gamma analysis also showed significant differences between both approaches, especially for the target volumes.
Conclusion:
Monte Carlo calculations with fast algorithms is practical and should be considered for the clinic, at least as a treatment plan verification tool.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><doi>10.1118/1.4956284</doi><tpages>1</tpages></addata></record> |
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| source | Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | 60 APPLIED LIFE SCIENCES ALGORITHMS Anatomy CALCULATORS Cancer Drug delivery EDUCATIONAL FACILITIES EVALUATION Monte Carlo algorithms MONTE CARLO METHOD PATIENTS PROTON BEAMS Proton therapy Protons RADIATION DOSE DISTRIBUTIONS RADIATION PROTECTION AND DOSIMETRY RADIOTHERAPY |
| title | SU-F-T-148: Are the Approximations in Analytic Semi-Empirical Dose Calculation Algorithms for Intensity Modulated Proton Therapy for Complex Heterogeneities of Head and Neck Clinically Significant? |
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