SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy
Purpose: To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tom...
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| Veröffentlicht in: | Medical physics (Lancaster) 2016-06, Vol.43 (6), p.3425-3425 |
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| creator | Matney, J Hammers, J Kaidar-Person, O Wang, A Chen, R Das, S Marks, L Mavroidis, P |
| description | Purpose:
To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy.
Methods:
A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations. The physician-approved CTV and organ and risk (OAR) contours were deformed from the pCT to daily CBCT over the course of treatment. The same structures were delineated on each daily CBCT by a radiation oncologist. Dice similarity coefficient (DSC) mean and standard deviations were calculated to quantify the deformable registration quality for prostate, bladder, rectum and femoral heads.
Results:
To date, contour comparisons have been analyzed for 31 daily fractions of 2 of 10 of the cohort. Interim analysis shows that right and left femoral head contours demonstrate the highest agreement (DSC: 0.96±0.02) with physician contours. Additionally, deformed bladder (DSC: 0.81±0.09) and prostate (DSC: 0.80±0.07) have good agreement with physician-defined daily contours. Rectum contours have the highest variations (DSC: 0.66±0.10) between the deformed and physician-defined contours on daily CBCT imaging.
Conclusion:
For structures with relatively high contrast boundaries on CBCT, the MIM automated deformable registration provided accurate representations of the daily contours during treatment delivery. These findings will permit subsequent investigations to automate daily dose computation from CBCT. However, improved methods need to be investigated to improve deformable results for rectum contours. |
| doi_str_mv | 10.1118/1.4955989 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1118_1_4955989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>MP5989</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1359-809693a91a928ffdc9f4f5ab18d0d6df60fe05d892b29ebb844ceb37a225de3a3</originalsourceid><addsrcrecordid>eNp90c1u1DAQB3ALUYmlcOANLHGhSC6281GbWwn9VKuuyvYcTZzxblBirxxvq7wWT4iX7JWefJjf_GfkIeST4KdCCPVNnOa6KLTSb8hC5mcZyyXXb8mCc50zmfPiHXk_jr8552VW8AX58-uJXbJbpsR3evEM_Q5i5x31lp7voh8gYkt_ovVhgKZH-ojrboxhRj8wviA6uuzBuc6taeWH7W7fsfKDXwfYbib6pVqdUHApBbp-SsRhaoSBVit6M8AaR_rwjIHGDabiLoy4H74MfoxpOK3AmVR9hLbziaTM6QM5stCP-PHwHpOny4tVdc3uHq5uqvM7ZkRWaKa4LnUGWoCWytrWaJvbAhqhWt6WrS25RV60SstGamwalecGm-wMpCxazCA7Jp_n3LRKV4-mi2g2xjuHJtZSlpmUXCV1MiuTVh4D2nobugHCVAte709Si_pwkmTZbF-6Hqf_w_p-efBfZ78f_u_PXwn_C2Lqmfk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy</title><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Matney, J ; Hammers, J ; Kaidar-Person, O ; Wang, A ; Chen, R ; Das, S ; Marks, L ; Mavroidis, P</creator><creatorcontrib>Matney, J ; Hammers, J ; Kaidar-Person, O ; Wang, A ; Chen, R ; Das, S ; Marks, L ; Mavroidis, P</creatorcontrib><description>Purpose:
To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy.
Methods:
A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations. The physician-approved CTV and organ and risk (OAR) contours were deformed from the pCT to daily CBCT over the course of treatment. The same structures were delineated on each daily CBCT by a radiation oncologist. Dice similarity coefficient (DSC) mean and standard deviations were calculated to quantify the deformable registration quality for prostate, bladder, rectum and femoral heads.
Results:
To date, contour comparisons have been analyzed for 31 daily fractions of 2 of 10 of the cohort. Interim analysis shows that right and left femoral head contours demonstrate the highest agreement (DSC: 0.96±0.02) with physician contours. Additionally, deformed bladder (DSC: 0.81±0.09) and prostate (DSC: 0.80±0.07) have good agreement with physician-defined daily contours. Rectum contours have the highest variations (DSC: 0.66±0.10) between the deformed and physician-defined contours on daily CBCT imaging.
Conclusion:
For structures with relatively high contrast boundaries on CBCT, the MIM automated deformable registration provided accurate representations of the daily contours during treatment delivery. These findings will permit subsequent investigations to automate daily dose computation from CBCT. However, improved methods need to be investigated to improve deformable results for rectum contours.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4955989</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>60 APPLIED LIFE SCIENCES ; ANATOMY ; BEAMS ; BIOMEDICAL RADIOGRAPHY ; BLADDER ; CALCULATION METHODS ; CALORIMETRY ; Cancer ; COMPUTER CODES ; Computer software ; COMPUTERIZED TOMOGRAPHY ; Cone beam computed tomography ; Dosimetry ; HEAD ; IMAGE PROCESSING ; Medical imaging ; MEDICAL PERSONNEL ; Medical treatment planning ; NEOPLASMS ; PATIENTS ; PLANNING ; PROSTATE ; RADIATION DOSES ; RADIATION PROTECTION AND DOSIMETRY ; Radiation treatment ; RADIOTHERAPY ; RECTUM</subject><ispartof>Medical physics (Lancaster), 2016-06, Vol.43 (6), p.3425-3425</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2016 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4955989$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45575</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22632208$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Matney, J</creatorcontrib><creatorcontrib>Hammers, J</creatorcontrib><creatorcontrib>Kaidar-Person, O</creatorcontrib><creatorcontrib>Wang, A</creatorcontrib><creatorcontrib>Chen, R</creatorcontrib><creatorcontrib>Das, S</creatorcontrib><creatorcontrib>Marks, L</creatorcontrib><creatorcontrib>Mavroidis, P</creatorcontrib><title>SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy</title><title>Medical physics (Lancaster)</title><description>Purpose:
To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy.
Methods:
A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations. The physician-approved CTV and organ and risk (OAR) contours were deformed from the pCT to daily CBCT over the course of treatment. The same structures were delineated on each daily CBCT by a radiation oncologist. Dice similarity coefficient (DSC) mean and standard deviations were calculated to quantify the deformable registration quality for prostate, bladder, rectum and femoral heads.
Results:
To date, contour comparisons have been analyzed for 31 daily fractions of 2 of 10 of the cohort. Interim analysis shows that right and left femoral head contours demonstrate the highest agreement (DSC: 0.96±0.02) with physician contours. Additionally, deformed bladder (DSC: 0.81±0.09) and prostate (DSC: 0.80±0.07) have good agreement with physician-defined daily contours. Rectum contours have the highest variations (DSC: 0.66±0.10) between the deformed and physician-defined contours on daily CBCT imaging.
Conclusion:
For structures with relatively high contrast boundaries on CBCT, the MIM automated deformable registration provided accurate representations of the daily contours during treatment delivery. These findings will permit subsequent investigations to automate daily dose computation from CBCT. However, improved methods need to be investigated to improve deformable results for rectum contours.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>ANATOMY</subject><subject>BEAMS</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>BLADDER</subject><subject>CALCULATION METHODS</subject><subject>CALORIMETRY</subject><subject>Cancer</subject><subject>COMPUTER CODES</subject><subject>Computer software</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Cone beam computed tomography</subject><subject>Dosimetry</subject><subject>HEAD</subject><subject>IMAGE PROCESSING</subject><subject>Medical imaging</subject><subject>MEDICAL PERSONNEL</subject><subject>Medical treatment planning</subject><subject>NEOPLASMS</subject><subject>PATIENTS</subject><subject>PLANNING</subject><subject>PROSTATE</subject><subject>RADIATION DOSES</subject><subject>RADIATION PROTECTION AND DOSIMETRY</subject><subject>Radiation treatment</subject><subject>RADIOTHERAPY</subject><subject>RECTUM</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp90c1u1DAQB3ALUYmlcOANLHGhSC6281GbWwn9VKuuyvYcTZzxblBirxxvq7wWT4iX7JWefJjf_GfkIeST4KdCCPVNnOa6KLTSb8hC5mcZyyXXb8mCc50zmfPiHXk_jr8552VW8AX58-uJXbJbpsR3evEM_Q5i5x31lp7voh8gYkt_ovVhgKZH-ojrboxhRj8wviA6uuzBuc6taeWH7W7fsfKDXwfYbib6pVqdUHApBbp-SsRhaoSBVit6M8AaR_rwjIHGDabiLoy4H74MfoxpOK3AmVR9hLbziaTM6QM5stCP-PHwHpOny4tVdc3uHq5uqvM7ZkRWaKa4LnUGWoCWytrWaJvbAhqhWt6WrS25RV60SstGamwalecGm-wMpCxazCA7Jp_n3LRKV4-mi2g2xjuHJtZSlpmUXCV1MiuTVh4D2nobugHCVAte709Si_pwkmTZbF-6Hqf_w_p-efBfZ78f_u_PXwn_C2Lqmfk</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Matney, J</creator><creator>Hammers, J</creator><creator>Kaidar-Person, O</creator><creator>Wang, A</creator><creator>Chen, R</creator><creator>Das, S</creator><creator>Marks, L</creator><creator>Mavroidis, P</creator><general>American Association of Physicists in Medicine</general><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>201606</creationdate><title>SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy</title><author>Matney, J ; Hammers, J ; Kaidar-Person, O ; Wang, A ; Chen, R ; Das, S ; Marks, L ; Mavroidis, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1359-809693a91a928ffdc9f4f5ab18d0d6df60fe05d892b29ebb844ceb37a225de3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>ANATOMY</topic><topic>BEAMS</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>BLADDER</topic><topic>CALCULATION METHODS</topic><topic>CALORIMETRY</topic><topic>Cancer</topic><topic>COMPUTER CODES</topic><topic>Computer software</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Cone beam computed tomography</topic><topic>Dosimetry</topic><topic>HEAD</topic><topic>IMAGE PROCESSING</topic><topic>Medical imaging</topic><topic>MEDICAL PERSONNEL</topic><topic>Medical treatment planning</topic><topic>NEOPLASMS</topic><topic>PATIENTS</topic><topic>PLANNING</topic><topic>PROSTATE</topic><topic>RADIATION DOSES</topic><topic>RADIATION PROTECTION AND DOSIMETRY</topic><topic>Radiation treatment</topic><topic>RADIOTHERAPY</topic><topic>RECTUM</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matney, J</creatorcontrib><creatorcontrib>Hammers, J</creatorcontrib><creatorcontrib>Kaidar-Person, O</creatorcontrib><creatorcontrib>Wang, A</creatorcontrib><creatorcontrib>Chen, R</creatorcontrib><creatorcontrib>Das, S</creatorcontrib><creatorcontrib>Marks, L</creatorcontrib><creatorcontrib>Mavroidis, P</creatorcontrib><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matney, J</au><au>Hammers, J</au><au>Kaidar-Person, O</au><au>Wang, A</au><au>Chen, R</au><au>Das, S</au><au>Marks, L</au><au>Mavroidis, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy</atitle><jtitle>Medical physics (Lancaster)</jtitle><date>2016-06</date><risdate>2016</risdate><volume>43</volume><issue>6</issue><spage>3425</spage><epage>3425</epage><pages>3425-3425</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy.
Methods:
A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations. The physician-approved CTV and organ and risk (OAR) contours were deformed from the pCT to daily CBCT over the course of treatment. The same structures were delineated on each daily CBCT by a radiation oncologist. Dice similarity coefficient (DSC) mean and standard deviations were calculated to quantify the deformable registration quality for prostate, bladder, rectum and femoral heads.
Results:
To date, contour comparisons have been analyzed for 31 daily fractions of 2 of 10 of the cohort. Interim analysis shows that right and left femoral head contours demonstrate the highest agreement (DSC: 0.96±0.02) with physician contours. Additionally, deformed bladder (DSC: 0.81±0.09) and prostate (DSC: 0.80±0.07) have good agreement with physician-defined daily contours. Rectum contours have the highest variations (DSC: 0.66±0.10) between the deformed and physician-defined contours on daily CBCT imaging.
Conclusion:
For structures with relatively high contrast boundaries on CBCT, the MIM automated deformable registration provided accurate representations of the daily contours during treatment delivery. These findings will permit subsequent investigations to automate daily dose computation from CBCT. However, improved methods need to be investigated to improve deformable results for rectum contours.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><doi>10.1118/1.4955989</doi><tpages>1</tpages></addata></record> |
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| source | Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | 60 APPLIED LIFE SCIENCES ANATOMY BEAMS BIOMEDICAL RADIOGRAPHY BLADDER CALCULATION METHODS CALORIMETRY Cancer COMPUTER CODES Computer software COMPUTERIZED TOMOGRAPHY Cone beam computed tomography Dosimetry HEAD IMAGE PROCESSING Medical imaging MEDICAL PERSONNEL Medical treatment planning NEOPLASMS PATIENTS PLANNING PROSTATE RADIATION DOSES RADIATION PROTECTION AND DOSIMETRY Radiation treatment RADIOTHERAPY RECTUM |
| title | SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy |
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