Validity of model approximations for receptor-ligand kinetics in nuclear medicine

An appropriate mathematical model is required for quantitative analysis of high affinity radioligands as direct or surrogate probes to measure receptor distribution, affinity, concentration, binding potential, and endogenous or exogenous ligand occupancy levels. For studies with positron emission to...

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Veröffentlicht in:	Medical physics (Lancaster) 2007-05, Vol.34 (5), p.1693-1703
Hauptverfasser:	Salinas, Cristian A., Muzic, Raymond F., Saidel, Gerald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	APPROXIMATIONS Biomedical modeling Computer simulation COMPUTERIZED SIMULATION DIFFERENTIAL EQUATIONS Equations of state Experiment design LIGANDS Membrane Proteins - metabolism Models, Theoretical nonlinear differential equations NUCLEAR MEDICINE Numerical modeling NUMERICAL SOLUTION Ordinary differential equations POSITRON COMPUTED TOMOGRAPHY positron emission tomography Positron emission tomography (PET) Positron-Emission Tomography - methods RADIATION DOSES Radioactive decay Radioactivity RADIOLOGY AND NUCLEAR MEDICINE RADIOPHARMACEUTICALS Radiopharmaceuticals - metabolism RECEPTORS SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY Single photon emission computed tomography (SPECT) Tomography, Emission-Computed, Single-Photon - methods
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