Recent developments in the management of Rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory condition that affects 1% of adult population. The characteristic symptoms of RA, such as joint pain and stiffness, typically get worse in the morning and are strongly related with severe co-morbidities. The range of pro-and anti-inflammatory cytokines has rapidly increased, and the discovery of new members has shown that they play varying degrees of roles in causing chronic immune cell related inflammatory conditions such as RA. It is crucial to give novel substances to patients who do not respond to currently available strategies, such as glucocorticoids, T-cell targeted therapies, TNF-alpha inhibitors, etc., in order to develop new targeted therapies. This review paper’s goal is to give an insight into of the role of newly discovered cytokines-the diseases caused by them and their potential in the therapy in RA. A thorough literature review was done to find articles related to any cytokine the study covered. As per some studies, there is sufficient evidence from RA patients and animal models to proceed with medication discovery, whereas in others conflicting analyses and insufficient knowledge call for more research.