The use of partially pregelatinized starch from cassava as disintegrant
The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially prege...
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| creator | Sabirin Darussalam, Abdullah Kusarpoko, Budi Safrudin, Ahmad Mawarni, Gabriela Kasih Suparman Musa |
| description | The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study 7 formulas were used with different disintegrants, 3 formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, and 3 formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and 1 control formula without disintegrant. The experimental design used was a Randomized Block Design. The tablet is made using a wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, the compatibility of partially pregelatinized starch from cassava was carried out and compared with avicel, starch 1500, and cassava starch. The results showed that partially pregelatinized starch from cassava-produced tablets tended to be capping with less hardness than tablets with starch 1500 and control tablets. The compatibility test showed that partially pregelatinized starch from cassava was better than starch 1500 and cassava starch. The disintegration test showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas. |
| doi_str_mv | 10.1063/5.0184050 |
| format | Conference Proceeding |
| fullrecord | <record><control><sourceid>proquest_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1063_5_0184050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2922638866</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1680-8aeec1f72a29e08e49dab0e76839f173c2c24320e2425cb0f7357e5113bff9833</originalsourceid><addsrcrecordid>eNotkE1LwzAYx4MoOKcHv0HAm9D5JGnejjJ0CgMvE7yVrHuyZXRtTVJhfnor2-l_-fF_I-SewYyBEk9yBsyUIOGCTJiUrNCKqUsyAbBlwUvxdU1uUtoDcKu1mZDFaod0SEg7T3sXc3BNc6R9xC02Loc2_OKGpuxivaM-dgdau5Tcj6Mu0U1Ioc24ja7Nt-TKuybh3Vmn5PP1ZTV_K5Yfi_f587LomTJQGIdYM6-54xbBYGk3bg2olRHWMy1qXo8lOSAvuazX4LWQGiVjYu29NUJMycPJt4_d94ApV_tuiO0YWXHLuRLGKDVSjycq1SGPM7q26mM4uHisGFT_R1WyOh8l_gCu5VnP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype><pqid>2922638866</pqid></control><display><type>conference_proceeding</type><title>The use of partially pregelatinized starch from cassava as disintegrant</title><source>American Institute of Physics (AIP) Journals</source><creator>Sabirin ; Darussalam, Abdullah ; Kusarpoko, Budi ; Safrudin, Ahmad ; Mawarni, Gabriela Kasih ; Suparman ; Musa</creator><contributor>Putri, Ezi Masdia ; Atmoko, Bayu Andri ; Kurniawan, Hakim ; Wulandari ; Widodo, Slamet ; Hudaya, Mohammad Firdaus ; Purba, Riris Delima ; Harsonowati, Wiwiek</contributor><creatorcontrib>Sabirin ; Darussalam, Abdullah ; Kusarpoko, Budi ; Safrudin, Ahmad ; Mawarni, Gabriela Kasih ; Suparman ; Musa ; Putri, Ezi Masdia ; Atmoko, Bayu Andri ; Kurniawan, Hakim ; Wulandari ; Widodo, Slamet ; Hudaya, Mohammad Firdaus ; Purba, Riris Delima ; Harsonowati, Wiwiek</creatorcontrib><description>The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study 7 formulas were used with different disintegrants, 3 formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, and 3 formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and 1 control formula without disintegrant. The experimental design used was a Randomized Block Design. The tablet is made using a wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, the compatibility of partially pregelatinized starch from cassava was carried out and compared with avicel, starch 1500, and cassava starch. The results showed that partially pregelatinized starch from cassava-produced tablets tended to be capping with less hardness than tablets with starch 1500 and control tablets. The compatibility test showed that partially pregelatinized starch from cassava was better than starch 1500 and cassava starch. The disintegration test showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0184050</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Cassava ; Compatibility ; Design of experiments ; Disintegration ; Dissolution ; Formulations ; Granulation ; Hardness ; Physical properties ; Tablets</subject><ispartof>AIP Conference Proceedings, 2024, Vol.2957 (1)</ispartof><rights>Author(s)</rights><rights>2024 Author(s). Published by AIP Publishing.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/acp/article-lookup/doi/10.1063/5.0184050$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,794,4512,23930,23931,25140,27924,27925,76384</link.rule.ids></links><search><contributor>Putri, Ezi Masdia</contributor><contributor>Atmoko, Bayu Andri</contributor><contributor>Kurniawan, Hakim</contributor><contributor>Wulandari</contributor><contributor>Widodo, Slamet</contributor><contributor>Hudaya, Mohammad Firdaus</contributor><contributor>Purba, Riris Delima</contributor><contributor>Harsonowati, Wiwiek</contributor><creatorcontrib>Sabirin</creatorcontrib><creatorcontrib>Darussalam, Abdullah</creatorcontrib><creatorcontrib>Kusarpoko, Budi</creatorcontrib><creatorcontrib>Safrudin, Ahmad</creatorcontrib><creatorcontrib>Mawarni, Gabriela Kasih</creatorcontrib><creatorcontrib>Suparman</creatorcontrib><creatorcontrib>Musa</creatorcontrib><title>The use of partially pregelatinized starch from cassava as disintegrant</title><title>AIP Conference Proceedings</title><description>The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study 7 formulas were used with different disintegrants, 3 formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, and 3 formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and 1 control formula without disintegrant. The experimental design used was a Randomized Block Design. The tablet is made using a wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, the compatibility of partially pregelatinized starch from cassava was carried out and compared with avicel, starch 1500, and cassava starch. The results showed that partially pregelatinized starch from cassava-produced tablets tended to be capping with less hardness than tablets with starch 1500 and control tablets. The compatibility test showed that partially pregelatinized starch from cassava was better than starch 1500 and cassava starch. The disintegration test showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.</description><subject>Cassava</subject><subject>Compatibility</subject><subject>Design of experiments</subject><subject>Disintegration</subject><subject>Dissolution</subject><subject>Formulations</subject><subject>Granulation</subject><subject>Hardness</subject><subject>Physical properties</subject><subject>Tablets</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2024</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNotkE1LwzAYx4MoOKcHv0HAm9D5JGnejjJ0CgMvE7yVrHuyZXRtTVJhfnor2-l_-fF_I-SewYyBEk9yBsyUIOGCTJiUrNCKqUsyAbBlwUvxdU1uUtoDcKu1mZDFaod0SEg7T3sXc3BNc6R9xC02Loc2_OKGpuxivaM-dgdau5Tcj6Mu0U1Ioc24ja7Nt-TKuybh3Vmn5PP1ZTV_K5Yfi_f587LomTJQGIdYM6-54xbBYGk3bg2olRHWMy1qXo8lOSAvuazX4LWQGiVjYu29NUJMycPJt4_d94ApV_tuiO0YWXHLuRLGKDVSjycq1SGPM7q26mM4uHisGFT_R1WyOh8l_gCu5VnP</recordid><startdate>20240206</startdate><enddate>20240206</enddate><creator>Sabirin</creator><creator>Darussalam, Abdullah</creator><creator>Kusarpoko, Budi</creator><creator>Safrudin, Ahmad</creator><creator>Mawarni, Gabriela Kasih</creator><creator>Suparman</creator><creator>Musa</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20240206</creationdate><title>The use of partially pregelatinized starch from cassava as disintegrant</title><author>Sabirin ; Darussalam, Abdullah ; Kusarpoko, Budi ; Safrudin, Ahmad ; Mawarni, Gabriela Kasih ; Suparman ; Musa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1680-8aeec1f72a29e08e49dab0e76839f173c2c24320e2425cb0f7357e5113bff9833</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cassava</topic><topic>Compatibility</topic><topic>Design of experiments</topic><topic>Disintegration</topic><topic>Dissolution</topic><topic>Formulations</topic><topic>Granulation</topic><topic>Hardness</topic><topic>Physical properties</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabirin</creatorcontrib><creatorcontrib>Darussalam, Abdullah</creatorcontrib><creatorcontrib>Kusarpoko, Budi</creatorcontrib><creatorcontrib>Safrudin, Ahmad</creatorcontrib><creatorcontrib>Mawarni, Gabriela Kasih</creatorcontrib><creatorcontrib>Suparman</creatorcontrib><creatorcontrib>Musa</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabirin</au><au>Darussalam, Abdullah</au><au>Kusarpoko, Budi</au><au>Safrudin, Ahmad</au><au>Mawarni, Gabriela Kasih</au><au>Suparman</au><au>Musa</au><au>Putri, Ezi Masdia</au><au>Atmoko, Bayu Andri</au><au>Kurniawan, Hakim</au><au>Wulandari</au><au>Widodo, Slamet</au><au>Hudaya, Mohammad Firdaus</au><au>Purba, Riris Delima</au><au>Harsonowati, Wiwiek</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>The use of partially pregelatinized starch from cassava as disintegrant</atitle><btitle>AIP Conference Proceedings</btitle><date>2024-02-06</date><risdate>2024</risdate><volume>2957</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>The use of partially pregelatinized starch in tablet formulations is quite extensive, one of them is a disintegrant agent. The sources of starch are also very broad, including cassava which is quite abundant in Indonesia. The purpose of this study was to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study 7 formulas were used with different disintegrants, 3 formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, and 3 formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and 1 control formula without disintegrant. The experimental design used was a Randomized Block Design. The tablet is made using a wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, the compatibility of partially pregelatinized starch from cassava was carried out and compared with avicel, starch 1500, and cassava starch. The results showed that partially pregelatinized starch from cassava-produced tablets tended to be capping with less hardness than tablets with starch 1500 and control tablets. The compatibility test showed that partially pregelatinized starch from cassava was better than starch 1500 and cassava starch. The disintegration test showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0184050</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP Conference Proceedings, 2024, Vol.2957 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_scitation_primary_10_1063_5_0184050 |
| source | American Institute of Physics (AIP) Journals |
| subjects | Cassava Compatibility Design of experiments Disintegration Dissolution Formulations Granulation Hardness Physical properties Tablets |
| title | The use of partially pregelatinized starch from cassava as disintegrant |
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