Evaluation of in silico anti-inflammatory potential of bioactive compound in Anguilla bicolor

Evaluation of in silico anti-inflammatory potential of bioactive compound in Anguilla bicolor

The Indonesian shortfin eel (Anguilla bicolor) is an eel species that inhabits the waters of Indonesia. Eel has a high nutrient, vitamin, and micronutrient content. It has been reported that eel contains secondary metabolites with anti-inflammatory, anticancer, antibacterial, antifungal, antioxidant...

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Hauptverfasser: Dzikrina, Hanina, Fadillah, Siti Awalia Nur, Yuniar, Shintya, Surakusumah, Wahyu, Kusumawaty, Diah, Tallei, Trina Ekawati
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Atherosclerosis
Blood vessels
Endothelial cells
Fungicides
Metabolites
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creator Dzikrina, Hanina
Fadillah, Siti Awalia Nur
Yuniar, Shintya
Surakusumah, Wahyu
Kusumawaty, Diah
Tallei, Trina Ekawati
description The Indonesian shortfin eel (Anguilla bicolor) is an eel species that inhabits the waters of Indonesia. Eel has a high nutrient, vitamin, and micronutrient content. It has been reported that eel contains secondary metabolites with anti-inflammatory, anticancer, antibacterial, antifungal, antioxidant, and antiviral properties. Atherosclerosis is one of the diseases that can be caused by the inflammatory process. Atherosclerosis is a condition that occurs when plaque forms and thickens on the inner walls of blood vessels. The purpose of this study was to analyze in silico the anti-inflammatory potential of eel metabolites. The results indicated that Indonesian shortfin eel contains compounds with anti-inflammatory properties, particularly related to atherosclerosis. The compound 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine binds to NF-κb protein, thereby preventing an increase in endothelial cell permeability, the cause of chronic inflammation in atherosclerosis.
doi_str_mv 10.1063/5.0119233
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subjects Atherosclerosis
Blood vessels
Endothelial cells
Fungicides
Metabolites
title Evaluation of in silico anti-inflammatory potential of bioactive compound in Anguilla bicolor
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