Molecular modeling study and antifungal activity of some synthesized quinoline derivatives

The chemical reactivity and stability of three prepared compounds (5-7) have been studied using molecular modelling. According to the results, compound 7 is more reactive than compounds 5 and 6. Antifungal activity was confirmed for all the compounds and proved that the compound 6 has been shown to...

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Hauptverfasser: Zinad, Dhafer S., Salman, Ghazwan A., Mahal, Ahmed, Hussein, Fadhela M.
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creator Zinad, Dhafer S.
Salman, Ghazwan A.
Mahal, Ahmed
Hussein, Fadhela M.
description The chemical reactivity and stability of three prepared compounds (5-7) have been studied using molecular modelling. According to the results, compound 7 is more reactive than compounds 5 and 6. Antifungal activity was confirmed for all the compounds and proved that the compound 6 has been shown to have a potent zone of inhibition against Aspergillus niger in comparison to the reference drug used of Amphotericin B, while compounds 5 and 7 showed significant activity than the positive control.
doi_str_mv 10.1063/5.0118611
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source AIP Journals Complete
subjects Chemical synthesis
Fungicides
Quinoline
title Molecular modeling study and antifungal activity of some synthesized quinoline derivatives
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