Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals
Biological probes facilitate optical imaging and disease diagnosis and treatment. However, the large absorption and scattering loss in the tissue highly limit the depth during the application. In the present research, an NIR-I bioprobing system, which utilizes the Bessel beam to excite heavily dopin...
Gespeichert in:
Veröffentlicht in: | Applied physics letters 2022-07, Vol.121 (4) |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 4 |
container_start_page | |
container_title | Applied physics letters |
container_volume | 121 |
creator | Ning, Danyang Xu, Li Zhu, Yin Li, Dongyu Jiang, Haili Carvajal, Joan Josep Li, Hanyang Ren, Jing Liu, Lu Zhang, Jianzhong |
description | Biological probes facilitate optical imaging and disease diagnosis and treatment. However, the large absorption and scattering loss in the tissue highly limit the depth during the application. In the present research, an NIR-I bioprobing system, which utilizes the Bessel beam to excite heavily doping nanocrystals, has been developed for deep tissue applications. On the one hand, the capillary mode selection method generates the Bessel excitation beam, lowering the excitation energy loss. On the other hand, a strong energy harvest of NaYbF4:90%Nd nanocrystals enables effective fluorescence and heat generation upon 800 nm excitation. By considering the advantages of Bessel excitation and heavily doping nanocrystals, up to ∼3 cm penetration depth for ex vivo bioimaging and the potential self-monitored photothermal treatment are demonstrated. The resultant bioprobing system allows deep tissue imaging and photothermal therapy, showcasing broad prospects in medical research and clinical applications. |
doi_str_mv | 10.1063/5.0095439 |
format | Article |
fullrecord | <record><control><sourceid>proquest_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1063_5_0095439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2694063331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c327t-60f8cd288d912a4e65edbb8ea91405f9e20980967f4fcf7f53258d219b2920193</originalsourceid><addsrcrecordid>eNqd0E1LwzAYB_AgCs7pwW9Q8KTQLS9N2xx1zBcYetGDp5A2T2bHlnRJO9i3N6UD717yJOGXJzx_hG4JnhGcszmfYSx4xsQZmhBcFCkjpDxHE4wxS3PBySW6CmETj5wyNkH7JwgBtkkFapc0Vvc16EQDtGkLFjqvusauk6pxzU6th62yOokPTLpztumcj_wHRtWHYX3X8-9quDs022OiXRuFVdbV_hg6tQ3X6MLEAjenOkVfz8vPxWu6-nh5Wzyu0prRoktzbMpa07LUglCVQc5BV1UJSpAMcyOAYlFikRcmM7UpDGeUl5oSUVFBMRFsiu7Gvq13-x5CJzeu9zZ-KWkushgWYySq-1HV3oXgwcjWx1H9URIsh0Qll6dEo30YbaibLo7s7P_wwfk_KFtt2C-G5YUN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2694063331</pqid></control><display><type>article</type><title>Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals</title><source>AIP Journals Complete</source><source>Alma/SFX Local Collection</source><creator>Ning, Danyang ; Xu, Li ; Zhu, Yin ; Li, Dongyu ; Jiang, Haili ; Carvajal, Joan Josep ; Li, Hanyang ; Ren, Jing ; Liu, Lu ; Zhang, Jianzhong</creator><creatorcontrib>Ning, Danyang ; Xu, Li ; Zhu, Yin ; Li, Dongyu ; Jiang, Haili ; Carvajal, Joan Josep ; Li, Hanyang ; Ren, Jing ; Liu, Lu ; Zhang, Jianzhong</creatorcontrib><description>Biological probes facilitate optical imaging and disease diagnosis and treatment. However, the large absorption and scattering loss in the tissue highly limit the depth during the application. In the present research, an NIR-I bioprobing system, which utilizes the Bessel beam to excite heavily doping nanocrystals, has been developed for deep tissue applications. On the one hand, the capillary mode selection method generates the Bessel excitation beam, lowering the excitation energy loss. On the other hand, a strong energy harvest of NaYbF4:90%Nd nanocrystals enables effective fluorescence and heat generation upon 800 nm excitation. By considering the advantages of Bessel excitation and heavily doping nanocrystals, up to ∼3 cm penetration depth for ex vivo bioimaging and the potential self-monitored photothermal treatment are demonstrated. The resultant bioprobing system allows deep tissue imaging and photothermal therapy, showcasing broad prospects in medical research and clinical applications.</description><identifier>ISSN: 0003-6951</identifier><identifier>EISSN: 1077-3118</identifier><identifier>DOI: 10.1063/5.0095439</identifier><identifier>CODEN: APPLAB</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Applied physics ; Beams (radiation) ; Doping ; Energy harvesting ; Excitation ; Health services ; Heat generation ; Medical imaging ; Medical research ; Modal choice ; Nanocrystals ; Penetration depth</subject><ispartof>Applied physics letters, 2022-07, Vol.121 (4)</ispartof><rights>Author(s)</rights><rights>2022 Author(s). Published under an exclusive license by AIP Publishing.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-60f8cd288d912a4e65edbb8ea91405f9e20980967f4fcf7f53258d219b2920193</citedby><cites>FETCH-LOGICAL-c327t-60f8cd288d912a4e65edbb8ea91405f9e20980967f4fcf7f53258d219b2920193</cites><orcidid>0000-0003-3516-004X ; 0000-0001-9657-484X ; 0000-0003-3001-7754 ; 0000-0001-9744-6006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/apl/article-lookup/doi/10.1063/5.0095439$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>314,780,784,794,4512,27924,27925,76384</link.rule.ids></links><search><creatorcontrib>Ning, Danyang</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Zhu, Yin</creatorcontrib><creatorcontrib>Li, Dongyu</creatorcontrib><creatorcontrib>Jiang, Haili</creatorcontrib><creatorcontrib>Carvajal, Joan Josep</creatorcontrib><creatorcontrib>Li, Hanyang</creatorcontrib><creatorcontrib>Ren, Jing</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Zhang, Jianzhong</creatorcontrib><title>Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals</title><title>Applied physics letters</title><description>Biological probes facilitate optical imaging and disease diagnosis and treatment. However, the large absorption and scattering loss in the tissue highly limit the depth during the application. In the present research, an NIR-I bioprobing system, which utilizes the Bessel beam to excite heavily doping nanocrystals, has been developed for deep tissue applications. On the one hand, the capillary mode selection method generates the Bessel excitation beam, lowering the excitation energy loss. On the other hand, a strong energy harvest of NaYbF4:90%Nd nanocrystals enables effective fluorescence and heat generation upon 800 nm excitation. By considering the advantages of Bessel excitation and heavily doping nanocrystals, up to ∼3 cm penetration depth for ex vivo bioimaging and the potential self-monitored photothermal treatment are demonstrated. The resultant bioprobing system allows deep tissue imaging and photothermal therapy, showcasing broad prospects in medical research and clinical applications.</description><subject>Applied physics</subject><subject>Beams (radiation)</subject><subject>Doping</subject><subject>Energy harvesting</subject><subject>Excitation</subject><subject>Health services</subject><subject>Heat generation</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Modal choice</subject><subject>Nanocrystals</subject><subject>Penetration depth</subject><issn>0003-6951</issn><issn>1077-3118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqd0E1LwzAYB_AgCs7pwW9Q8KTQLS9N2xx1zBcYetGDp5A2T2bHlnRJO9i3N6UD717yJOGXJzx_hG4JnhGcszmfYSx4xsQZmhBcFCkjpDxHE4wxS3PBySW6CmETj5wyNkH7JwgBtkkFapc0Vvc16EQDtGkLFjqvusauk6pxzU6th62yOokPTLpztumcj_wHRtWHYX3X8-9quDs022OiXRuFVdbV_hg6tQ3X6MLEAjenOkVfz8vPxWu6-nh5Wzyu0prRoktzbMpa07LUglCVQc5BV1UJSpAMcyOAYlFikRcmM7UpDGeUl5oSUVFBMRFsiu7Gvq13-x5CJzeu9zZ-KWkushgWYySq-1HV3oXgwcjWx1H9URIsh0Qll6dEo30YbaibLo7s7P_wwfk_KFtt2C-G5YUN</recordid><startdate>20220725</startdate><enddate>20220725</enddate><creator>Ning, Danyang</creator><creator>Xu, Li</creator><creator>Zhu, Yin</creator><creator>Li, Dongyu</creator><creator>Jiang, Haili</creator><creator>Carvajal, Joan Josep</creator><creator>Li, Hanyang</creator><creator>Ren, Jing</creator><creator>Liu, Lu</creator><creator>Zhang, Jianzhong</creator><general>American Institute of Physics</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-3516-004X</orcidid><orcidid>https://orcid.org/0000-0001-9657-484X</orcidid><orcidid>https://orcid.org/0000-0003-3001-7754</orcidid><orcidid>https://orcid.org/0000-0001-9744-6006</orcidid></search><sort><creationdate>20220725</creationdate><title>Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals</title><author>Ning, Danyang ; Xu, Li ; Zhu, Yin ; Li, Dongyu ; Jiang, Haili ; Carvajal, Joan Josep ; Li, Hanyang ; Ren, Jing ; Liu, Lu ; Zhang, Jianzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-60f8cd288d912a4e65edbb8ea91405f9e20980967f4fcf7f53258d219b2920193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Applied physics</topic><topic>Beams (radiation)</topic><topic>Doping</topic><topic>Energy harvesting</topic><topic>Excitation</topic><topic>Health services</topic><topic>Heat generation</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Modal choice</topic><topic>Nanocrystals</topic><topic>Penetration depth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ning, Danyang</creatorcontrib><creatorcontrib>Xu, Li</creatorcontrib><creatorcontrib>Zhu, Yin</creatorcontrib><creatorcontrib>Li, Dongyu</creatorcontrib><creatorcontrib>Jiang, Haili</creatorcontrib><creatorcontrib>Carvajal, Joan Josep</creatorcontrib><creatorcontrib>Li, Hanyang</creatorcontrib><creatorcontrib>Ren, Jing</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Zhang, Jianzhong</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Applied physics letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ning, Danyang</au><au>Xu, Li</au><au>Zhu, Yin</au><au>Li, Dongyu</au><au>Jiang, Haili</au><au>Carvajal, Joan Josep</au><au>Li, Hanyang</au><au>Ren, Jing</au><au>Liu, Lu</au><au>Zhang, Jianzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals</atitle><jtitle>Applied physics letters</jtitle><date>2022-07-25</date><risdate>2022</risdate><volume>121</volume><issue>4</issue><issn>0003-6951</issn><eissn>1077-3118</eissn><coden>APPLAB</coden><abstract>Biological probes facilitate optical imaging and disease diagnosis and treatment. However, the large absorption and scattering loss in the tissue highly limit the depth during the application. In the present research, an NIR-I bioprobing system, which utilizes the Bessel beam to excite heavily doping nanocrystals, has been developed for deep tissue applications. On the one hand, the capillary mode selection method generates the Bessel excitation beam, lowering the excitation energy loss. On the other hand, a strong energy harvest of NaYbF4:90%Nd nanocrystals enables effective fluorescence and heat generation upon 800 nm excitation. By considering the advantages of Bessel excitation and heavily doping nanocrystals, up to ∼3 cm penetration depth for ex vivo bioimaging and the potential self-monitored photothermal treatment are demonstrated. The resultant bioprobing system allows deep tissue imaging and photothermal therapy, showcasing broad prospects in medical research and clinical applications.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0095439</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3516-004X</orcidid><orcidid>https://orcid.org/0000-0001-9657-484X</orcidid><orcidid>https://orcid.org/0000-0003-3001-7754</orcidid><orcidid>https://orcid.org/0000-0001-9744-6006</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0003-6951 |
ispartof | Applied physics letters, 2022-07, Vol.121 (4) |
issn | 0003-6951 1077-3118 |
language | eng |
recordid | cdi_scitation_primary_10_1063_5_0095439 |
source | AIP Journals Complete; Alma/SFX Local Collection |
subjects | Applied physics Beams (radiation) Doping Energy harvesting Excitation Health services Heat generation Medical imaging Medical research Modal choice Nanocrystals Penetration depth |
title | Bessel beam induced deep-penetrating bioimaging and self-monitored heating using Nd/Yb heavily doped nanocrystals |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T20%3A52%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_scita&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bessel%20beam%20induced%20deep-penetrating%20bioimaging%20and%20self-monitored%20heating%20using%20Nd/Yb%20heavily%20doped%20nanocrystals&rft.jtitle=Applied%20physics%20letters&rft.au=Ning,%20Danyang&rft.date=2022-07-25&rft.volume=121&rft.issue=4&rft.issn=0003-6951&rft.eissn=1077-3118&rft.coden=APPLAB&rft_id=info:doi/10.1063/5.0095439&rft_dat=%3Cproquest_scita%3E2694063331%3C/proquest_scita%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2694063331&rft_id=info:pmid/&rfr_iscdi=true |