An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob)
Malaria is a deadly and serious disease caused by infected female anopheles mosquito. The efforts to discover new antimalarial agents are being done continuously, including through exploration of active compounds from nature. The research aimed to investigate the in vitro antimalarial activity of Li...
Gespeichert in:
Hauptverfasser: | , , , |
---|---|
Format: | Tagungsbericht |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 1 |
container_start_page | |
container_title | |
container_volume | 2360 |
creator | Lestari, Yuni Selvi Yuanmizesfi, Enggo Zamri, Adel Teruna, Hilwan Y. |
description | Malaria is a deadly and serious disease caused by infected female anopheles mosquito. The efforts to discover new antimalarial agents are being done continuously, including through exploration of active compounds from nature. The research aimed to investigate the in vitro antimalarial activity of Litseaglutinosa stem barks collected in Riau Province, Indonesia. Giemsa was used to stain chloroquine-sensitive Plasmodium falciparum in the blood. An alkaloid (compound 1) was isolated from the n-hexane extract, as reported previously. The antimalarial of the stem barks showed IC50 value of larger than 10 µg/ml. Therefore it can be concluded that the compound possesses moderate potential as antimalarial agent. |
doi_str_mv | 10.1063/5.0060175 |
format | Conference Proceeding |
fullrecord | <record><control><sourceid>proquest_scita</sourceid><recordid>TN_cdi_scitation_primary_10_1063_5_0060175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577189829</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2035-e5da161bcec56b7e89eb8834bf4fbfd39aaa078b1d53f968987929cd451bc84a3</originalsourceid><addsrcrecordid>eNp9kF9LwzAUxYMoOKcPfoOAL05oTZqmaR7n8B8MBFHwQQi3TToyu6QmmeC3t7KBbz5dOPzOPfcehM4pySmp2DXPCakIFfwATSjnNBMVrQ7RhBBZZkXJ3o7RSYxrQgopRD1B73OHwSW7gR6ChR633sVk09a4hLvgNxj6D-i91XhjNLgV7o3TNuDLpU3RAF7122SdjzAqfhvyGV7k-CbHz76ZnaKjDvpozvZzil7vbl8WD9ny6f5xMV9mQ0EYzwzXQCvatKblVSNMLU1T16xsurJrOs0kABBRN1Rz1smqlrWQhWx1yUdPXQKboovd3iH4z62JSa3HU9wYqQouBB0dhRypqx0VW5sgWe_UEMbHw7eiRP22p7jat_cf_OXDH6gG3bEfwsFvLQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype><pqid>2577189829</pqid></control><display><type>conference_proceeding</type><title>An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob)</title><source>AIP Journals Complete</source><creator>Lestari, Yuni Selvi ; Yuanmizesfi, Enggo ; Zamri, Adel ; Teruna, Hilwan Y.</creator><contributor>Sutapa, I Wayan ; Maahury, Mirella Fonda ; Batkunde, Hermanus ; Elim, Hendry Isaac ; Matdoan, Muh. Yahya ; Joris, Shielda Natalis ; Seumahu, Cecilia Anna</contributor><creatorcontrib>Lestari, Yuni Selvi ; Yuanmizesfi, Enggo ; Zamri, Adel ; Teruna, Hilwan Y. ; Sutapa, I Wayan ; Maahury, Mirella Fonda ; Batkunde, Hermanus ; Elim, Hendry Isaac ; Matdoan, Muh. Yahya ; Joris, Shielda Natalis ; Seumahu, Cecilia Anna</creatorcontrib><description>Malaria is a deadly and serious disease caused by infected female anopheles mosquito. The efforts to discover new antimalarial agents are being done continuously, including through exploration of active compounds from nature. The research aimed to investigate the in vitro antimalarial activity of Litseaglutinosa stem barks collected in Riau Province, Indonesia. Giemsa was used to stain chloroquine-sensitive Plasmodium falciparum in the blood. An alkaloid (compound 1) was isolated from the n-hexane extract, as reported previously. The antimalarial of the stem barks showed IC50 value of larger than 10 µg/ml. Therefore it can be concluded that the compound possesses moderate potential as antimalarial agent.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0060175</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Alkaloids ; Hexanes ; Malaria ; Stems</subject><ispartof>AIP Conference Proceedings, 2021, Vol.2360 (1)</ispartof><rights>Author(s)</rights><rights>2021 Author(s). Published by AIP Publishing.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/acp/article-lookup/doi/10.1063/5.0060175$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,796,4514,23937,23938,25147,27931,27932,76392</link.rule.ids></links><search><contributor>Sutapa, I Wayan</contributor><contributor>Maahury, Mirella Fonda</contributor><contributor>Batkunde, Hermanus</contributor><contributor>Elim, Hendry Isaac</contributor><contributor>Matdoan, Muh. Yahya</contributor><contributor>Joris, Shielda Natalis</contributor><contributor>Seumahu, Cecilia Anna</contributor><creatorcontrib>Lestari, Yuni Selvi</creatorcontrib><creatorcontrib>Yuanmizesfi, Enggo</creatorcontrib><creatorcontrib>Zamri, Adel</creatorcontrib><creatorcontrib>Teruna, Hilwan Y.</creatorcontrib><title>An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob)</title><title>AIP Conference Proceedings</title><description>Malaria is a deadly and serious disease caused by infected female anopheles mosquito. The efforts to discover new antimalarial agents are being done continuously, including through exploration of active compounds from nature. The research aimed to investigate the in vitro antimalarial activity of Litseaglutinosa stem barks collected in Riau Province, Indonesia. Giemsa was used to stain chloroquine-sensitive Plasmodium falciparum in the blood. An alkaloid (compound 1) was isolated from the n-hexane extract, as reported previously. The antimalarial of the stem barks showed IC50 value of larger than 10 µg/ml. Therefore it can be concluded that the compound possesses moderate potential as antimalarial agent.</description><subject>Alkaloids</subject><subject>Hexanes</subject><subject>Malaria</subject><subject>Stems</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2021</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kF9LwzAUxYMoOKcPfoOAL05oTZqmaR7n8B8MBFHwQQi3TToyu6QmmeC3t7KBbz5dOPzOPfcehM4pySmp2DXPCakIFfwATSjnNBMVrQ7RhBBZZkXJ3o7RSYxrQgopRD1B73OHwSW7gR6ChR633sVk09a4hLvgNxj6D-i91XhjNLgV7o3TNuDLpU3RAF7122SdjzAqfhvyGV7k-CbHz76ZnaKjDvpozvZzil7vbl8WD9ny6f5xMV9mQ0EYzwzXQCvatKblVSNMLU1T16xsurJrOs0kABBRN1Rz1smqlrWQhWx1yUdPXQKboovd3iH4z62JSa3HU9wYqQouBB0dhRypqx0VW5sgWe_UEMbHw7eiRP22p7jat_cf_OXDH6gG3bEfwsFvLQ</recordid><startdate>20210928</startdate><enddate>20210928</enddate><creator>Lestari, Yuni Selvi</creator><creator>Yuanmizesfi, Enggo</creator><creator>Zamri, Adel</creator><creator>Teruna, Hilwan Y.</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20210928</creationdate><title>An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob)</title><author>Lestari, Yuni Selvi ; Yuanmizesfi, Enggo ; Zamri, Adel ; Teruna, Hilwan Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2035-e5da161bcec56b7e89eb8834bf4fbfd39aaa078b1d53f968987929cd451bc84a3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alkaloids</topic><topic>Hexanes</topic><topic>Malaria</topic><topic>Stems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lestari, Yuni Selvi</creatorcontrib><creatorcontrib>Yuanmizesfi, Enggo</creatorcontrib><creatorcontrib>Zamri, Adel</creatorcontrib><creatorcontrib>Teruna, Hilwan Y.</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lestari, Yuni Selvi</au><au>Yuanmizesfi, Enggo</au><au>Zamri, Adel</au><au>Teruna, Hilwan Y.</au><au>Sutapa, I Wayan</au><au>Maahury, Mirella Fonda</au><au>Batkunde, Hermanus</au><au>Elim, Hendry Isaac</au><au>Matdoan, Muh. Yahya</au><au>Joris, Shielda Natalis</au><au>Seumahu, Cecilia Anna</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob)</atitle><btitle>AIP Conference Proceedings</btitle><date>2021-09-28</date><risdate>2021</risdate><volume>2360</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Malaria is a deadly and serious disease caused by infected female anopheles mosquito. The efforts to discover new antimalarial agents are being done continuously, including through exploration of active compounds from nature. The research aimed to investigate the in vitro antimalarial activity of Litseaglutinosa stem barks collected in Riau Province, Indonesia. Giemsa was used to stain chloroquine-sensitive Plasmodium falciparum in the blood. An alkaloid (compound 1) was isolated from the n-hexane extract, as reported previously. The antimalarial of the stem barks showed IC50 value of larger than 10 µg/ml. Therefore it can be concluded that the compound possesses moderate potential as antimalarial agent.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0060175</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0094-243X |
ispartof | AIP Conference Proceedings, 2021, Vol.2360 (1) |
issn | 0094-243X 1551-7616 |
language | eng |
recordid | cdi_scitation_primary_10_1063_5_0060175 |
source | AIP Journals Complete |
subjects | Alkaloids Hexanes Malaria Stems |
title | An antimalarial constituent from alkaloid medang lendir (Litsea glutinosa (Lour.) C. B. Rob) |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T17%3A00%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_scita&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=An%20antimalarial%20constituent%20from%20alkaloid%20medang%20lendir%20(Litsea%20glutinosa%20(Lour.)%20C.%20B.%20Rob)&rft.btitle=AIP%20Conference%20Proceedings&rft.au=Lestari,%20Yuni%20Selvi&rft.date=2021-09-28&rft.volume=2360&rft.issue=1&rft.issn=0094-243X&rft.eissn=1551-7616&rft.coden=APCPCS&rft_id=info:doi/10.1063/5.0060175&rft_dat=%3Cproquest_scita%3E2577189829%3C/proquest_scita%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2577189829&rft_id=info:pmid/&rfr_iscdi=true |