Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is cancer with a high prevalence in the world, Asia, and Indonesia. Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and signi...
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| creator | Susanto, Hendra Yunisa, Dinda Tri Taufiq, Ahmad Putra, Wira Eka Jannah, Nur Raiyan Putri, Shabrina Andira Dewi, Ikke Astrid Febriyanti, Qori Dini Ayu Mufidah, Ikfi Nihayatul |
| description | Hepatocellular carcinoma (HCC) is cancer with a high prevalence in the world, Asia, and Indonesia. Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and significantly correlates to the transforming growth factor-beta (TGF-β) expression. TGF-β leads to disease progression stages, from early liver damage through inflammation and fibrosis to cirrhosis and (HCC). The purpose of this study is to investigate the effect of green material Moringa oleifera on the expression of TGF-β in the mice model develop to HCC. This study was conducted using a BALB C mice model treated with intraperitoneal injections of green material Moringa oleifera +CCl4 at a dose of 1 µL/1 g of BW for six weeks. The result shows a significant effect of green material Moringa oleifera on the decrease in TGF-β expression. Hence, green material Moringa oleifera can be a potential preventative agent for liver fibrogenesis-linked HCC. |
| doi_str_mv | 10.1063/5.0052554 |
| format | Conference Proceeding |
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Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and significantly correlates to the transforming growth factor-beta (TGF-β) expression. TGF-β leads to disease progression stages, from early liver damage through inflammation and fibrosis to cirrhosis and (HCC). The purpose of this study is to investigate the effect of green material Moringa oleifera on the expression of TGF-β in the mice model develop to HCC. This study was conducted using a BALB C mice model treated with intraperitoneal injections of green material Moringa oleifera +CCl4 at a dose of 1 µL/1 g of BW for six weeks. The result shows a significant effect of green material Moringa oleifera on the decrease in TGF-β expression. Hence, green material Moringa oleifera can be a potential preventative agent for liver fibrogenesis-linked HCC.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0052554</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Cancer ; Fibrosis ; Growth factors ; Liver ; Liver cancer ; Metabolic disorders</subject><ispartof>AIP conference proceedings, 2021, Vol.2353 (1)</ispartof><rights>Author(s)</rights><rights>2021 Author(s). 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Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and significantly correlates to the transforming growth factor-beta (TGF-β) expression. TGF-β leads to disease progression stages, from early liver damage through inflammation and fibrosis to cirrhosis and (HCC). The purpose of this study is to investigate the effect of green material Moringa oleifera on the expression of TGF-β in the mice model develop to HCC. This study was conducted using a BALB C mice model treated with intraperitoneal injections of green material Moringa oleifera +CCl4 at a dose of 1 µL/1 g of BW for six weeks. The result shows a significant effect of green material Moringa oleifera on the decrease in TGF-β expression. Hence, green material Moringa oleifera can be a potential preventative agent for liver fibrogenesis-linked HCC.</description><subject>Cancer</subject><subject>Fibrosis</subject><subject>Growth factors</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Metabolic disorders</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2021</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kE1LAzEQhoMoWKsH_0HAiwpbk81mP46l-AUt9aDgbZnNTtqU7WZNUsWLv91IBW-ehmEennl5CTnnbMJZLm7khDGZSpkdkBGXkidFzvNDMmKsypI0E6_H5MT7DWNpVRTliHxN-2CoNo2zK-zRG09Ra1SBWk1XDrGnWwjoDHSeLqwz_Qqo7dBodEA7BE0H-9Gio5eL5fzpitqehjXSIfocem_iHk1rHCBYhV2368BRBU6Z3m7hlBzpaMaz3zkmL3e3z7OHZL68f5xN58mQMpEloLOCN4yBaKVIlchKga0qmwJANYxDq5niOW_KNAMOMp4iVjFdVg2mVSXFmFzsvTHX2w59qDd25_r4sk6l4EXJWVlF6npPeWUChJi9HpzZgvusOat_-q1l_dvvf_C7dX9gPbRafAMGsHzX</recordid><startdate>20210525</startdate><enddate>20210525</enddate><creator>Susanto, Hendra</creator><creator>Yunisa, Dinda Tri</creator><creator>Taufiq, Ahmad</creator><creator>Putra, Wira Eka</creator><creator>Jannah, Nur Raiyan</creator><creator>Putri, Shabrina Andira</creator><creator>Dewi, Ikke Astrid</creator><creator>Febriyanti, Qori Dini Ayu</creator><creator>Mufidah, Ikfi Nihayatul</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20210525</creationdate><title>Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma</title><author>Susanto, Hendra ; Yunisa, Dinda Tri ; Taufiq, Ahmad ; Putra, Wira Eka ; Jannah, Nur Raiyan ; Putri, Shabrina Andira ; Dewi, Ikke Astrid ; Febriyanti, Qori Dini Ayu ; Mufidah, Ikfi Nihayatul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2034-af471b00a3d532c3483edc8b7aacb01adf0c161b824a1a5dc853290f89be29953</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer</topic><topic>Fibrosis</topic><topic>Growth factors</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Metabolic disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Susanto, Hendra</creatorcontrib><creatorcontrib>Yunisa, Dinda Tri</creatorcontrib><creatorcontrib>Taufiq, Ahmad</creatorcontrib><creatorcontrib>Putra, Wira Eka</creatorcontrib><creatorcontrib>Jannah, Nur Raiyan</creatorcontrib><creatorcontrib>Putri, Shabrina Andira</creatorcontrib><creatorcontrib>Dewi, Ikke Astrid</creatorcontrib><creatorcontrib>Febriyanti, Qori Dini Ayu</creatorcontrib><creatorcontrib>Mufidah, Ikfi Nihayatul</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Susanto, Hendra</au><au>Yunisa, Dinda Tri</au><au>Taufiq, Ahmad</au><au>Putra, Wira Eka</au><au>Jannah, Nur Raiyan</au><au>Putri, Shabrina Andira</au><au>Dewi, Ikke Astrid</au><au>Febriyanti, Qori Dini Ayu</au><au>Mufidah, Ikfi Nihayatul</au><au>Zubaidah, Siti</au><au>Sunaryono</au><au>Susanto, Hendra</au><au>Wang, I Ching</au><au>Taufiq, Ahmad</au><au>Wibowo, Indra</au><au>Nur, Hadi</au><au>Aulanni’am</au><au>Jemon, Khairunadwa Binti</au><au>Amin, Mohamad</au><au>Aziz, Muhammad</au><au>Mufti, Nandang</au><au>Diantoro, Markus</au><au>Ng, Chen Siang</au><au>Suksuwan, Acharee</au><au>Malek, Nik Ahmad Nizam Nik</au><au>Handaya, Adeodatus Yuda</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma</atitle><btitle>AIP conference proceedings</btitle><date>2021-05-25</date><risdate>2021</risdate><volume>2353</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Hepatocellular carcinoma (HCC) is cancer with a high prevalence in the world, Asia, and Indonesia. Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and significantly correlates to the transforming growth factor-beta (TGF-β) expression. TGF-β leads to disease progression stages, from early liver damage through inflammation and fibrosis to cirrhosis and (HCC). The purpose of this study is to investigate the effect of green material Moringa oleifera on the expression of TGF-β in the mice model develop to HCC. This study was conducted using a BALB C mice model treated with intraperitoneal injections of green material Moringa oleifera +CCl4 at a dose of 1 µL/1 g of BW for six weeks. The result shows a significant effect of green material Moringa oleifera on the decrease in TGF-β expression. 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| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
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| language | eng |
| recordid | cdi_scitation_primary_10_1063_5_0052554 |
| source | AIP Journals Complete |
| subjects | Cancer Fibrosis Growth factors Liver Liver cancer Metabolic disorders |
| title | Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma |
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