Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy
Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacit...
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| Veröffentlicht in: | Applied physics letters 2020-03, Vol.116 (12) |
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| container_title | Applied physics letters |
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| creator | Yu, Jiahuan Xu, Mengke Liang, Lingyan Guan, Min Zhang, Yang Yan, Feng Cao, Hongtao |
| description | Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10 ng/ml in both 0.1× and 1× phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec−1 at the critical concentration level of 2–8 ng/ml that enters the normal PSA region in the human body. The advantages of high sensitivity, low-cost, and convenience of usage make the proposed HEMT biosensors potential candidates for prostate cancer diagnosis. |
| doi_str_mv | 10.1063/5.0001786 |
| format | Article |
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The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10 ng/ml in both 0.1× and 1× phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec−1 at the critical concentration level of 2–8 ng/ml that enters the normal PSA region in the human body. 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The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10 ng/ml in both 0.1× and 1× phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec−1 at the critical concentration level of 2–8 ng/ml that enters the normal PSA region in the human body. The advantages of high sensitivity, low-cost, and convenience of usage make the proposed HEMT biosensors potential candidates for prostate cancer diagnosis.</description><subject>Aluminum gallium arsenides</subject><subject>Antigens</subject><subject>Applied physics</subject><subject>Biosensors</subject><subject>Capacitance</subject><subject>Electron mobility</subject><subject>Gallium arsenide</subject><subject>Prostate cancer</subject><subject>Saline solutions</subject><subject>Sensitivity</subject><subject>Strategy</subject><subject>Transistors</subject><issn>0003-6951</issn><issn>1077-3118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLAzEQhYMoWKsH_0HAk8K2maTJpsdStBUqHqwHTyGbna1b6mZNYrH_3i0VPQheZpjHxxveI-QS2ACYEkM5YIxBrtUR6QHL80wA6GPS61SRqbGEU3IW47o7JReiR16esLXBpnqLFD8TNiWW2compJPNzE7icD_o_PZhSYvaR2yiD5EWNmJJfUOdba2rk20cUvdqmxXSmDo7XO3OyUllNxEvvnefPN_dLqfzbPE4u59OFpkbcZ0yXqEQIBVXhSo0CqeVzNEqOdYAqK3jWruR5QV3ealLCQUHBpUDNi6ccFz0ydXBtw3-_QNjMmv_EZrupeFCc92FHrGOuj5QLvgYA1amDfWbDTsDzOybM9J8N9exNwc27qOl2jc_8NaHX9C0ZfUf_Nf5C0RKeyc</recordid><startdate>20200323</startdate><enddate>20200323</enddate><creator>Yu, Jiahuan</creator><creator>Xu, Mengke</creator><creator>Liang, Lingyan</creator><creator>Guan, Min</creator><creator>Zhang, Yang</creator><creator>Yan, Feng</creator><creator>Cao, Hongtao</creator><general>American Institute of Physics</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-6285-6600</orcidid><orcidid>https://orcid.org/0000-0001-7552-3656</orcidid><orcidid>https://orcid.org/0000-0001-8181-2024</orcidid></search><sort><creationdate>20200323</creationdate><title>Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy</title><author>Yu, Jiahuan ; Xu, Mengke ; Liang, Lingyan ; Guan, Min ; Zhang, Yang ; Yan, Feng ; Cao, Hongtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-2fe3315626b6b8e3c8657ea659811e8ac288c4a2b2c7d8d51b2101fc109bc3c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminum gallium arsenides</topic><topic>Antigens</topic><topic>Applied physics</topic><topic>Biosensors</topic><topic>Capacitance</topic><topic>Electron mobility</topic><topic>Gallium arsenide</topic><topic>Prostate cancer</topic><topic>Saline solutions</topic><topic>Sensitivity</topic><topic>Strategy</topic><topic>Transistors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Jiahuan</creatorcontrib><creatorcontrib>Xu, Mengke</creatorcontrib><creatorcontrib>Liang, Lingyan</creatorcontrib><creatorcontrib>Guan, Min</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Yan, Feng</creatorcontrib><creatorcontrib>Cao, Hongtao</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Applied physics letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Jiahuan</au><au>Xu, Mengke</au><au>Liang, Lingyan</au><au>Guan, Min</au><au>Zhang, Yang</au><au>Yan, Feng</au><au>Cao, Hongtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy</atitle><jtitle>Applied physics letters</jtitle><date>2020-03-23</date><risdate>2020</risdate><volume>116</volume><issue>12</issue><issn>0003-6951</issn><eissn>1077-3118</eissn><coden>APPLAB</coden><abstract>Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10 ng/ml in both 0.1× and 1× phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec−1 at the critical concentration level of 2–8 ng/ml that enters the normal PSA region in the human body. 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| identifier | ISSN: 0003-6951 |
| ispartof | Applied physics letters, 2020-03, Vol.116 (12) |
| issn | 0003-6951 1077-3118 |
| language | eng |
| recordid | cdi_scitation_primary_10_1063_5_0001786 |
| source | AIP Journals Complete; Alma/SFX Local Collection |
| subjects | Aluminum gallium arsenides Antigens Applied physics Biosensors Capacitance Electron mobility Gallium arsenide Prostate cancer Saline solutions Sensitivity Strategy Transistors |
| title | Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy |
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