Review on the changes of cytokines after traumatic brain injury
Inflammatory response after traumatic brain injury plays an essential role in secondary brain injury. Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are...
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| description | Inflammatory response after traumatic brain injury plays an essential role in secondary brain injury. Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are two kinds of cytokines involved in secondary brain injury and repair after brain trauma: pro-inflammatory cytokines and anti-inflammatory cytokines. Among them, nuclear factor kB(NF-kB), tumor necrosis factor α(TNF-α), soluble intercellular adhesion molecule 1(sICAM-1), vascular endothelial adhesion molecule 1(VCAM-1), and interleukin 1β(IL-1β), IL-6, IL-8, IL-16 are the major pro-inflammatory cytokines; IL-2, IL-4, IL-10 and IL-13are anti-inflammatory cytokines. This paper mainly summarizes the current research status of inflammatory cytokines, reaction mechanism and its relationship with TBI secondary brain injury. |
| doi_str_mv | 10.1063/5.0000364 |
| format | Conference Proceeding |
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Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are two kinds of cytokines involved in secondary brain injury and repair after brain trauma: pro-inflammatory cytokines and anti-inflammatory cytokines. Among them, nuclear factor kB(NF-kB), tumor necrosis factor α(TNF-α), soluble intercellular adhesion molecule 1(sICAM-1), vascular endothelial adhesion molecule 1(VCAM-1), and interleukin 1β(IL-1β), IL-6, IL-8, IL-16 are the major pro-inflammatory cytokines; IL-2, IL-4, IL-10 and IL-13are anti-inflammatory cytokines. This paper mainly summarizes the current research status of inflammatory cytokines, reaction mechanism and its relationship with TBI secondary brain injury.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0000364</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Adhesion ; Brain ; Cytokines ; Head injuries ; Inflammatory response ; Interleukins ; Reaction mechanisms ; Traumatic brain injury ; Tumor necrosis factor-TNF</subject><ispartof>AIP conference proceedings, 2020, Vol.2208 (1)</ispartof><rights>Author(s)</rights><rights>2020 Author(s). 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Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are two kinds of cytokines involved in secondary brain injury and repair after brain trauma: pro-inflammatory cytokines and anti-inflammatory cytokines. Among them, nuclear factor kB(NF-kB), tumor necrosis factor α(TNF-α), soluble intercellular adhesion molecule 1(sICAM-1), vascular endothelial adhesion molecule 1(VCAM-1), and interleukin 1β(IL-1β), IL-6, IL-8, IL-16 are the major pro-inflammatory cytokines; IL-2, IL-4, IL-10 and IL-13are anti-inflammatory cytokines. This paper mainly summarizes the current research status of inflammatory cytokines, reaction mechanism and its relationship with TBI secondary brain injury.</description><subject>Adhesion</subject><subject>Brain</subject><subject>Cytokines</subject><subject>Head injuries</subject><subject>Inflammatory response</subject><subject>Interleukins</subject><subject>Reaction mechanisms</subject><subject>Traumatic brain injury</subject><subject>Tumor necrosis factor-TNF</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2020</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kF9LwzAUxYMoOKcPfoOAb0LnzU3Tpk8iw38wEETBt5Amqct0aU3Tyb69lQ1887wcDvw493IIOWcwY1DwKzGDUbzID8iECcGysmDFIZkAVHmGOX87Jid9vwLAqizlhFw_u41337QNNC0dNUsd3l1P24aabWo_fBiDbpKLNEU9rHXyhtZR-0B9WA1xe0qOGv3Zu7O9T8nr3e3L_CFbPN0_zm8WWYeCp8xCyWSdcwtYO1M6K2tbSKwaLusCrRGiEo5pbGyNIB0g58YIUwkD4BCRT8nFrreL7dfg-qRW7RDDeFIhFxIgr1CO1OWO6o1P469tUF30ax23ioH6HUgJtR_oP3jTxj9QdbbhP-xDZcc</recordid><startdate>20200219</startdate><enddate>20200219</enddate><creator>Zhou, Yayue</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20200219</creationdate><title>Review on the changes of cytokines after traumatic brain injury</title><author>Zhou, Yayue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p253t-d0718b43d02bec7ed8bd6829f38b62dc5595e1a2fdb208e0233cc5c95c00e2223</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adhesion</topic><topic>Brain</topic><topic>Cytokines</topic><topic>Head injuries</topic><topic>Inflammatory response</topic><topic>Interleukins</topic><topic>Reaction mechanisms</topic><topic>Traumatic brain injury</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Yayue</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Yayue</au><au>Yang, Lv</au><au>Xiao, Jun</au><au>Ke, Xiaotian</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Review on the changes of cytokines after traumatic brain injury</atitle><btitle>AIP conference proceedings</btitle><date>2020-02-19</date><risdate>2020</risdate><volume>2208</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Inflammatory response after traumatic brain injury plays an essential role in secondary brain injury. Cytokines, as critical inflammatory mediators in vivo, are involved in a variety of pathophysiological processes and play a significant role in the inflammatory cascade after brain injury. There are two kinds of cytokines involved in secondary brain injury and repair after brain trauma: pro-inflammatory cytokines and anti-inflammatory cytokines. Among them, nuclear factor kB(NF-kB), tumor necrosis factor α(TNF-α), soluble intercellular adhesion molecule 1(sICAM-1), vascular endothelial adhesion molecule 1(VCAM-1), and interleukin 1β(IL-1β), IL-6, IL-8, IL-16 are the major pro-inflammatory cytokines; IL-2, IL-4, IL-10 and IL-13are anti-inflammatory cytokines. This paper mainly summarizes the current research status of inflammatory cytokines, reaction mechanism and its relationship with TBI secondary brain injury.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0000364</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2020, Vol.2208 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_scitation_primary_10_1063_5_0000364 |
| source | AIP Journals Complete |
| subjects | Adhesion Brain Cytokines Head injuries Inflammatory response Interleukins Reaction mechanisms Traumatic brain injury Tumor necrosis factor-TNF |
| title | Review on the changes of cytokines after traumatic brain injury |
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