In vivo mapping of current density distribution in brain tissues during deep brain stimulation (DBS)
New methods for in vivo mapping of brain responses during deep brain stimulation (DBS) are indispensable to secure clinical applications. Assessment of current density distribution, induced by internally injected currents, may provide an alternative method for understanding the therapeutic effects o...
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| Veröffentlicht in: | AIP advances 2017-01, Vol.7 (1), p.015004-015004-6 |
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| container_end_page | 015004-6 |
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| creator | Sajib, Saurav Z. K. Oh, Tong In Kim, Hyung Joong Kwon, Oh In Woo, Eung Je |
| description | New methods for in vivo mapping of brain responses during deep brain stimulation (DBS) are indispensable to secure clinical applications. Assessment of current density distribution, induced by internally injected currents, may provide an alternative method for understanding the therapeutic effects of electrical stimulation. The current flow and pathway are affected by internal conductivity, and can be imaged using magnetic resonance-based conductivity imaging methods. Magnetic resonance electrical impedance tomography (MREIT) is an imaging method that can enable highly resolved mapping of electromagnetic tissue properties such as current density and conductivity of living tissues. In the current study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The current density maps of three canine brains were calculated from the measured magnetic flux density data. The absolute current density values of brain tissues, including gray matter, white matter, and cerebrospinal fluid were compared to assess the active regions during DBS. The resulting current density in different tissue types may provide useful information about current pathways and volume activation for adjusting surgical planning and understanding the therapeutic effects of DBS. |
| doi_str_mv | 10.1063/1.4973818 |
| format | Article |
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In the current study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The current density maps of three canine brains were calculated from the measured magnetic flux density data. The absolute current density values of brain tissues, including gray matter, white matter, and cerebrospinal fluid were compared to assess the active regions during DBS. 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Magnetic resonance electrical impedance tomography (MREIT) is an imaging method that can enable highly resolved mapping of electromagnetic tissue properties such as current density and conductivity of living tissues. In the current study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The current density maps of three canine brains were calculated from the measured magnetic flux density data. The absolute current density values of brain tissues, including gray matter, white matter, and cerebrospinal fluid were compared to assess the active regions during DBS. The resulting current density in different tissue types may provide useful information about current pathways and volume activation for adjusting surgical planning and understanding the therapeutic effects of DBS.</description><subject>Brain</subject><subject>Cerebrospinal fluid</subject><subject>Current density</subject><subject>Current distribution</subject><subject>Density distribution</subject><subject>Electrical impedance</subject><subject>Electrical resistivity</subject><subject>Flux density</subject><subject>In vivo methods and tests</subject><subject>Magnetic flux</subject><subject>Magnetic resonance</subject><subject>Magnetism</subject><subject>Mapping</subject><subject>Medical imaging</subject><subject>Stimulation</subject><issn>2158-3226</issn><issn>2158-3226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kUtLAzEQxxdRUGoPfoOAFxWqeWzS5Kj1VRA8qOeQTWZLSrtZk2yh397tAxUE5zATJr_8ZyZTFGcEXxMs2A25LtWYSSIPihNKuBwxSsXhr_NxMUxpjnsrFcGyPCnctEErvwpoadrWNzMUamS7GKHJyEGTfF4j51OOvuqyDw3yDaqi6X32KXWQkOvi5p0DaPc3KftltzBb_OL-7u3ytDiqzSLBcB8Hxcfjw_vkefTy-jSd3L6MbEllHo2ZqCozFhaqGpQwQBXjmBJnlMWWUkslp1AZDhWx2BECpla4nxgUVbUVbFBMd7oumLluo1-auNbBeL1NhDjTJmZvF6CZcLR2RnDgtuQMSyadwUQZPqYKiOy1zndabQyf_ZxZz0MXm759TQkthSoxxz11uaNsDClFqL-rEqw3O9FE73fSs1c7Nlmft7_zDa9C_AF16-r_4L_KX4nvmgM</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Sajib, Saurav Z. 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K. ; Oh, Tong In ; Kim, Hyung Joong ; Kwon, Oh In ; Woo, Eung Je</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-736bba76cebfe96ae2935021da9c0c22c2852eba5eb1c0d11eaf90973e929fc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Brain</topic><topic>Cerebrospinal fluid</topic><topic>Current density</topic><topic>Current distribution</topic><topic>Density distribution</topic><topic>Electrical impedance</topic><topic>Electrical resistivity</topic><topic>Flux density</topic><topic>In vivo methods and tests</topic><topic>Magnetic flux</topic><topic>Magnetic resonance</topic><topic>Magnetism</topic><topic>Mapping</topic><topic>Medical imaging</topic><topic>Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sajib, Saurav Z. K.</creatorcontrib><creatorcontrib>Oh, Tong In</creatorcontrib><creatorcontrib>Kim, Hyung Joong</creatorcontrib><creatorcontrib>Kwon, Oh In</creatorcontrib><creatorcontrib>Woo, Eung Je</creatorcontrib><collection>AIP Open Access Journals</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>AIP advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sajib, Saurav Z. 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The current flow and pathway are affected by internal conductivity, and can be imaged using magnetic resonance-based conductivity imaging methods. Magnetic resonance electrical impedance tomography (MREIT) is an imaging method that can enable highly resolved mapping of electromagnetic tissue properties such as current density and conductivity of living tissues. In the current study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The current density maps of three canine brains were calculated from the measured magnetic flux density data. The absolute current density values of brain tissues, including gray matter, white matter, and cerebrospinal fluid were compared to assess the active regions during DBS. 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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Brain Cerebrospinal fluid Current density Current distribution Density distribution Electrical impedance Electrical resistivity Flux density In vivo methods and tests Magnetic flux Magnetic resonance Magnetism Mapping Medical imaging Stimulation |
| title | In vivo mapping of current density distribution in brain tissues during deep brain stimulation (DBS) |
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