Characterization of the infrared spectra of serum from patients with multiple myeloma
Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein...
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| creator | Plotnikova, L. Polyanichko, A. Nosenko, T. Uspenskaya, M. Garifullin, A. Voloshin, S. |
| description | Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors. |
| doi_str_mv | 10.1063/1.4960271 |
| format | Conference Proceeding |
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MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/1.4960271</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>DIAGNOSIS ; ELECTROPHORESIS ; IMMUNOGLOBULINS ; INFRARED SPECTRA ; Multiple myeloma ; NEOPLASMS ; PATIENTS ; PLASMA ; PLASMA CELLS ; PROLIFERATION ; PROTEIN STRUCTURE ; Proteins ; RADIOLOGY AND NUCLEAR MEDICINE ; RESOLUTION ; THERMAL ANALYSIS ; Thermodynamic properties</subject><ispartof>AIP conference proceedings, 2016, Vol.1760 (1)</ispartof><rights>Author(s)</rights><rights>2016 Author(s). Published by AIP Publishing.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-ce882f8a3d4423f72db5f4534f243dc64183b439f478be8db8e83823ed0b40db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://pubs.aip.org/acp/article-lookup/doi/10.1063/1.4960271$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>230,309,310,314,776,780,785,786,790,881,4497,23910,23911,25119,27903,27904,76130</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22608286$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><contributor>Naimark, Oleg B.</contributor><contributor>Sharkeev, Yurii P.</contributor><contributor>Gutmanas, Elazar Y.</contributor><creatorcontrib>Plotnikova, L.</creatorcontrib><creatorcontrib>Polyanichko, A.</creatorcontrib><creatorcontrib>Nosenko, T.</creatorcontrib><creatorcontrib>Uspenskaya, M.</creatorcontrib><creatorcontrib>Garifullin, A.</creatorcontrib><creatorcontrib>Voloshin, S.</creatorcontrib><title>Characterization of the infrared spectra of serum from patients with multiple myeloma</title><title>AIP conference proceedings</title><description>Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors.</description><subject>DIAGNOSIS</subject><subject>ELECTROPHORESIS</subject><subject>IMMUNOGLOBULINS</subject><subject>INFRARED SPECTRA</subject><subject>Multiple myeloma</subject><subject>NEOPLASMS</subject><subject>PATIENTS</subject><subject>PLASMA</subject><subject>PLASMA CELLS</subject><subject>PROLIFERATION</subject><subject>PROTEIN STRUCTURE</subject><subject>Proteins</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RESOLUTION</subject><subject>THERMAL ANALYSIS</subject><subject>Thermodynamic properties</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2016</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kctKxDAUhoMoOI4ufIOAO6Fjbm3TpQzeYMCNA-5CmgvN0DY1SZXx6W11YHauDhy-8_PxHwCuMVphVNA7vGJVgUiJT8AC5znOygIXp2CBUMUywuj7ObiIcYcQqcqSL8B23cggVTLBfcvkfA-9hakx0PU2yGA0jINRKch5H00YO2iD7-AwwaZPEX651MBubJMbWgO7vWl9Jy_BmZVtNFeHuQTbx4e39XO2eX16Wd9vMkUJTpkynBPLJdWMEWpLouvcspwyO5lqVTDMac1oZVnJa8N1zQ2nnFCjUc2QrukS3Pzl-piciMoloxrl-35SFoQUiBNeHKkh-I_RxCR2fgz9JCYIJrhEnNGZuv2j5pjfKsQQXCfDXnz6ILA4FCsGbf-DMRLzJ44H9AfQV3pz</recordid><startdate>20160802</startdate><enddate>20160802</enddate><creator>Plotnikova, L.</creator><creator>Polyanichko, A.</creator><creator>Nosenko, T.</creator><creator>Uspenskaya, M.</creator><creator>Garifullin, A.</creator><creator>Voloshin, S.</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>OTOTI</scope></search><sort><creationdate>20160802</creationdate><title>Characterization of the infrared spectra of serum from patients with multiple myeloma</title><author>Plotnikova, L. ; Polyanichko, A. ; Nosenko, T. ; Uspenskaya, M. ; Garifullin, A. ; Voloshin, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-ce882f8a3d4423f72db5f4534f243dc64183b439f478be8db8e83823ed0b40db3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2016</creationdate><topic>DIAGNOSIS</topic><topic>ELECTROPHORESIS</topic><topic>IMMUNOGLOBULINS</topic><topic>INFRARED SPECTRA</topic><topic>Multiple myeloma</topic><topic>NEOPLASMS</topic><topic>PATIENTS</topic><topic>PLASMA</topic><topic>PLASMA CELLS</topic><topic>PROLIFERATION</topic><topic>PROTEIN STRUCTURE</topic><topic>Proteins</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RESOLUTION</topic><topic>THERMAL ANALYSIS</topic><topic>Thermodynamic properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plotnikova, L.</creatorcontrib><creatorcontrib>Polyanichko, A.</creatorcontrib><creatorcontrib>Nosenko, T.</creatorcontrib><creatorcontrib>Uspenskaya, M.</creatorcontrib><creatorcontrib>Garifullin, A.</creatorcontrib><creatorcontrib>Voloshin, S.</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>OSTI.GOV</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plotnikova, L.</au><au>Polyanichko, A.</au><au>Nosenko, T.</au><au>Uspenskaya, M.</au><au>Garifullin, A.</au><au>Voloshin, S.</au><au>Naimark, Oleg B.</au><au>Sharkeev, Yurii P.</au><au>Gutmanas, Elazar Y.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Characterization of the infrared spectra of serum from patients with multiple myeloma</atitle><btitle>AIP conference proceedings</btitle><date>2016-08-02</date><risdate>2016</risdate><volume>1760</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Multiple myeloma (MM) accounts for about 1% of all types of cancers. MM is characterized by the proliferation of a single clone of plasma cells, which may produce and secrete a homogeneous monoclonal immunoglobulin. The monoclonal immunoglobulin is commonly referred to as an M protein. The M protein acts as a serological “tumor” marker that is useful for diagnosis and disease monitoring. The electrophoretic pattern reveals the M-protein in 80% of MM patients as a single peak or localized band. In our study we applied a combination of high-resolution agarose gel protein electrophoresis (PEL), spectroscopic techniques and thermal analysis to identify the key differences in protein composition, protein structure and their thermal behavior for the samples obtained from the serum of MM patients and healthy donors.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/1.4960271</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2016, Vol.1760 (1) |
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| language | eng |
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| source | AIP Journals Complete |
| subjects | DIAGNOSIS ELECTROPHORESIS IMMUNOGLOBULINS INFRARED SPECTRA Multiple myeloma NEOPLASMS PATIENTS PLASMA PLASMA CELLS PROLIFERATION PROTEIN STRUCTURE Proteins RADIOLOGY AND NUCLEAR MEDICINE RESOLUTION THERMAL ANALYSIS Thermodynamic properties |
| title | Characterization of the infrared spectra of serum from patients with multiple myeloma |
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